Advantages and applications of the centerline method for characterizing regional ventricular function.

Sheehan, Florence H.; Bolson, Edward L.; Dodge, Harold T.; Mathey, D; Schofer, Joachim; Woo, Hok-Wai

doi:10.1161/01.cir.74.2.293

Cited by 578 publications

(191 citation statements)

References 56 publications

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“…LV ejection fraction and volumes were calculated with the use of the area-length method, 12 and regional wall motion was determined with use of the centerline chord method. 13 …”

Section: Angiographymentioning

confidence: 99%

Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI)

et al. 2002

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Background-Experimental studies suggest that transplantation of blood-derived or bone marrow-derived progenitor cells beneficially affects postinfarction remodeling. The safety and feasibility of autologous progenitor cell transplantation in patients with ischemic heart disease is unknown. Methods and Results-We randomly allocated 20 patients with reperfused acute myocardial infarction (AMI) to receive intracoronary infusion of either bone marrow-derived (nϭ9) or circulating blood-derived progenitor cells (nϭ11) into the infarct artery 4.3Ϯ1.5 days after AMI. Transplantation of progenitor cells was associated with a significant increase in global left ventricular ejection fraction from 51.6Ϯ9.6% to 60.1Ϯ8.6% (Pϭ0.003), improved regional wall motion in the infarct zone (Ϫ1.5Ϯ0.2 to Ϫ0.5Ϯ0.7 SD/chord; PϽ0.001), and profoundly reduced end-systolic left ventricular volumes (56.1Ϯ20 mL to 42.2Ϯ15.1 mL; Pϭ0.01) at 4-month follow-up. In contrast, in a nonrandomized matched reference group, left ventricular ejection fraction only slightly increased from 51Ϯ10% to 53.5Ϯ7.9%, and end-systolic volumes remained unchanged. Echocardiography revealed a profound enhancement of regional contractile function (wall motion score index 1.4Ϯ0.2 at baseline versus 1.19Ϯ0.2 at follow-up; PϽ0.001). At 4 months, coronary blood flow reserve was significantly (PϽ0.001) increased in the infarct artery. Quantitative F-18-fluorodeoxyglucose-positron emission tomography analysis revealed a significant (PϽ0.01) increase in myocardial viability in the infarct zone. There were no differences for any measured parameter between blood-derived or bone marrow-derived progenitor cells. No signs of an inflammatory response or malignant arrhythmias were observed. Conclusions-In

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“…LV ejection fraction and volumes were calculated with the use of the area-length method, 12 and regional wall motion was determined with use of the centerline chord method. 13 …”

Section: Angiographymentioning

confidence: 99%

Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI)

et al. 2002

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“…The ejection fraction and the wall motion severity index (WMSI) (SD/chord) were calculated. 23 Quantitative angiography, using the smallest diameter from two orthogonal planes (QCA 4.0, Pie Medical Imaging), was done at baseline and follow-up. Restenosis was defined as a minimum luminal diameter of Ͻ50% of the reference diameter.…”

Section: Angiographic Analysismentioning

confidence: 99%

Regression of Collateral Function After Recanalization of Chronic Total Coronary Occlusions

et al. 2003

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Background-Collaterals can maintain myocardial function or preserve viability in chronic total coronary occlusions (CTOs). It is unknown whether and to what extent collaterals regress after successful recanalization of a CTO. Methods and Results-In 103 patients with successful recanalization of a CTO collateral function was assessed by intracoronary Doppler and pressure recordings before and after recanalization, and again after 5.0Ϯ1.3 months. Doppler (CFI) and pressure-derived collateral function indexes (CPI) and collateral (R Coll ) and peripheral resistance indexes (R P ) were calculated. In 10 patients with reocclusion, all without myocardial infarction during follow-up, collateral function had reached a similar level as before the first recanalization. In the other 93 patients with or without restenosis, collateral function was attenuated during follow-up. CPI had decreased by 23% immediately after recanalization (PϽ0.001) and decreased further by another 23% at follow-up (PϽ0.001). The R Coll increased immediately after recanalization by 82% (PϽ0.001) and by a further 273% at follow-up (PϽ0.001). In contrast, R P increased only by 22% after recanalization (PϽ0.001) and by an additional 12% at follow-up (PϽ0.05). The initial size of the collaterals but not the incidence of a restenosis influenced the collateral regression. Only 18% of patients at follow-up had collaterals with a CPI Ͼ0.30, presumably sufficient to prevent ischemia during acute occlusion. Conclusions-Collateral function regresses during long-term follow-up, especially in collaterals with a small diameter. In the majority of patients, collaterals are not readily recruitable in the case of acute occlusion. However, collaterals have the potential to recover in the case of chronic reocclusion.

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“…The centerline method of regional wall motion analysis was developed to address these concerns. Its sensitivity and specificity in detecting abnormal regional function compare favorably with rectangular and radial methods (Sheehan et al 1986) and its reliability has been previously documented (Sheehan et al 1983). In our present study, interobserver variability was larger than that of Sheehan's results (1983) measured from ventriculograms.…”

Section: Discussionmentioning

confidence: 87%

Left Ventricular Regional Wall Motion in the Early Neonatal Period.

Harada

Shiota

Noguchi

et al. 1995

Tohoku J. Exp. Med.

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To investigate the changes in regional wall motion of the left ventricle in the early neonatal period, serial echocardiography was performed in normal neonates at 2 and 120 hr after birth. Quantitative analysis of the regional wall motion was performed by the centerline method. We measured right ventricular systolic time intervals, left ventricular stroke volume, flow velocity-time integral of the pulmonary artery, and size of the ductus arteriosus. The ductus arteriosus was 4.5±0.5 mm at 2 hr but was closed in all subjects by 120 hr. At 2 hr, there was hyperkinesis of the interventricular septum which disappeared by 120 hr. The right ventricular systolic time intervals at 2 hr showed a sign of pulmonary hypertension. At 2 hr, the left ventricular stroke volume was at the highest level and the flow velocity-time intervals of pulmonary artery was at the lowest level. Thus the hyperkinesis of the interventricular septum at 2 hr might reflect the circulatory changes that are characteristic of the early neonatal period. echocardiography; neonate; left ventricular wall motionThe transition from the fetal to the neonatal circulatory status is accompanied by marked alteration of loading conditions. Two of the more important changes are the decrease in pulmonary artery pressure and the functional closure of the ductus arteriosus. The right ventricular pressure is approximately equal to the left ventricular pressure at birth and rapidly falls to near normal levels within a few days (Emmanouilides et al. 1964) In normal full-term neonates, the ductus arteriosus closes within the first day of life (Moss et al. 1963;Arcilla et al. 1967;Mahoney et al. 1985). These alterations after birth are considered to influence both global and regional performances of the left ventricle. Our previous studies demonstrated the changes in left ventricular function during the early neonatal period (Harada et al. 1994a, b; Takahashi et al. 1994a, b ) Although the left ventricular regional wall motion in normal newborns have been

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Advantages and applications of the centerline method for characterizing regional ventricular function.

Cited by 578 publications

References 56 publications

Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI)

Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI)

Regression of Collateral Function After Recanalization of Chronic Total Coronary Occlusions

Left Ventricular Regional Wall Motion in the Early Neonatal Period.

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