Advantages and Challenges of CRISPR-Cas9 Applications in Animal Modeling: A Concise Review CRISPR-Cas9 Applications in Animal Modeling
Ghasemian Abdolmajid,
Nournia Ensieh,
Nikfar Ghasem
et al.
Abstract:CRISPR is an extraordinarily powerful technique regulating any target gene across the genome with promising therapy intentions. CRISPR-Cas9 is a convenient tool for gene manipulation. Notwithstanding this, the broad consequence of human gene editing, particularly germinal genes, cannot be predicted. Firstly, once edited, the genes would be part of the human population for successive generations and may be impossible to remove from humanity; secondly, success is not guaranteed; thirdly, the fidelity of editing,… Show more
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