Advantages and challenges of oestrogen-free hormonal contraception

Ahrendt, Hans-Joachim; Adolf, Daniela

doi:10.1185/03007995.2010.493088

Cited by 16 publications

(11 citation statements)

References 65 publications

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“…The currently available ECs are mostly steroid based and therefore not devoid of steroidogenic side effects (Kahlenborn et al 2002, Ahrendt et al 2010. Puerarin may be projected as a prospective contraceptive molecule that can be further explored for the development of non-steroidal emergency/post-coital contraceptive.…”

Section: Discussionmentioning

confidence: 99%

“…EC, the contraceptive measures that can be taken after sex to prevent pregnancy (Sander et al 2009), is a popular form of reversible contraception. Oestrogens and progestins, individually or in combination, and antiprogestins form the active constituents of the currently available major hormonal EC formulations (Farrar et al 2003), but continuous usage of these formulations has undesirable effects that include the proliferative actions of oestrogenic component (Mersereau et al 2008) or higher failure rate and menstrual abnormalities associated with progestogen-only pills (Ahrendt et al 2010). Development of a safe and effective non-steroidal contraceptive formulation is therefore recognised as a global need of the day.…”

Section: Introductionmentioning

confidence: 99%

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Puerarin, a selective oestrogen receptor modulator, disrupts pregnancy in rats at pre-implantation stage

Saha¹,

Saraswat²,

Chakraborty³

et al. 2012

Reproduction

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The tubers of Pueraria tuberosa have folkloric repute as emmenagogue. The n-BuOH fraction of the ethanolic extract of tubers exhibits significant antifertility activity in laboratory animals. The present investigation explored the active principle(s) of the tuber extract with reference to contragestive effects in rats and probed the possible mechanism of action. Bioactivity-guided fractionation identified puerarin as the major constituent that exerted pregnancy-terminating effects. Oral administration of puerarin at R300 mg/kg per day for days (D) 1-2 post-coitus resulted in complete implantation failure. Serum oestradiol levels during D2-D5 and progesterone (P 4 ) level on D5 remained unaffected, but the endometrial expression of oestrogen receptor a (ERa) and ERb was adversely modulated that disrupted the implantation-specific characteristic endometrial oestrogenic milieu. The eventual consequence was loss of endometrial receptivity characterised by down-regulation of the uterine expression of P 4 receptor (PR) and attenuation of endometrial expression of leukaemia inhibitory factor, vascular endothelial growth factor and cyclo-oxygenase-2, the three important signalling molecules involved in the process of implantation. Light microscopic examination of the embryos demonstrated no untoward effect of puerarin on the development of embryos until D4, but D5 blastocysts underwent gross morphological distortion. The findings taken together are interpreted to suggest that puerarin adversely impacts the uterine expression of ER and PR that disrupts the implantation-conducive uterine milieu and prevents implantation. In conclusion, puerarin may be envisaged as a prospective molecule that merits further exploration for the development of non-steroidal post-coital contraceptive for women.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Puerarin, a selective oestrogen receptor modulator, disrupts pregnancy in rats at pre-implantation stage

Saha¹,

Saraswat²,

Chakraborty³

et al. 2012

Reproduction

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“…Some studies [47] have suggested that among Rwandan women, low use of hormonal contraceptive methods may be due to lack of access and availability, low knowledge, and cost. In the case of HIV+ women, studies [48–52] suggest that the low use of hormonal methods may be due to misconceptions leading to inconsistent use, concerns regarding hormonal methods' possible contribution to HIV transmission to sex partners or accelerated HIV disease progression and possible interaction with antiretroviral agents. The concerns on the interaction between hormonal methods with HIV acquisition and HIV-associated disease progression are areas of active research [53, 54].…”

Section: Discussionmentioning

confidence: 99%

Differences in the Nonuse of any Contraception and Use of Specific Contraceptive Methods in HIV Positive and HIV Negative Rwandan Women

Adedimeji

Hoover

Shi

et al. 2012

AIDS Research and Treatment

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Contraception can reduce the dual burden of high fertility and high HIV prevalence in sub-Sahara Africa, but significant barriers remain regarding access and use. We describe factors associated with nonuse of contraception and with use of specific contraceptive methods in HIV positive and HIV negative Rwandan women. Data from 395 HIV-positive and 76 HIV-negative women who desired no pregnancy in the previous 6 months were analyzed using univariate and multivariate logistic regression models to identify clinical and demographic characteristics that predict contraceptive use. Differences in contraceptive methods used were dependent on marital/partner status, partner's knowledge of a woman's HIV status, and age. Overall, condoms, abstinence, and hormonal methods were the most used, though differences existed by HIV status. Less than 10% of women both HIV+ and HIV− used no contraception. Important differences exist between HIV-positive and HIV-negative women with regard to contraceptive method use that should be addressed by interventions seeking to improve contraceptive prevalence.

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“…Irregular bleeding or menstrual disturbances are common with POPs (Ahrendt et al 2010;Faculty of Sexual and Reproductive Health Care 2009a). In the first 3 months around a third of women will experience a change in bleeding, with about 1 in 10 experiencing bleeding that is frequent i.e.…”

Section: Irregular Bleeding and Cycle Controlmentioning

confidence: 99%

Medicines For Women

Harrison‐Woolrych¹

2015

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Advantages and challenges of oestrogen-free hormonal contraception

Abstract: Progestogen-only pills offer an effective, convenient, and readily reversible method of contraception that is suitable for women with contraindications for oestrogens.

Cited by 16 publications

References 65 publications

Puerarin, a selective oestrogen receptor modulator, disrupts pregnancy in rats at pre-implantation stage

Puerarin, a selective oestrogen receptor modulator, disrupts pregnancy in rats at pre-implantation stage

Differences in the Nonuse of any Contraception and Use of Specific Contraceptive Methods in HIV Positive and HIV Negative Rwandan Women

Medicines For Women

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