Advantages and disadvantages of apoptosis in the aging process

Argüelles, Sandro; Guerrero‐Castilla, Angélica; Cano, Mercedes; Muñoz, Mario; Ayala, Antonio

doi:10.1111/nyas.14020

Cited by 50 publications

(22 citation statements)

References 79 publications

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“…Argüelles and colleagues propose that efficient apoptosis could be considered a pleiotropic aging factor, positive during development but negative during adulthood (Argüelles et al 2019). We suggest that the same logic applies to senescence: enhanced senescence may be a positive feature during development although accumulation of senescent cells in adulthood remains pro aging.…”

Section: Longevity Is Positively Associated With Stress Induced Senescencementioning

confidence: 66%

A pro longevity role for cellular senescence

et al. 2019

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Cellular senescence is a fundamental process that may play positive or detrimental roles for the organism. It is involved in tissue development and in tumor prevention although during aging is becoming a detrimental process contributing to the decline of tissue functions. In previous investigations, we have uncovered a better capacity to detect DNA damage in cells from long-lived mammals. Here, we report that cultured cells derived from long-lived species have a higher propensity to undergo senescence when challenged with DNA damage than cells derived from short-lived species. Using a panel of cells derived from six mammals, which range in lifespan from 3-4 years up to 120 years, we examined cell cycle response, induction of apoptosis

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Section: Longevity Is Positively Associated With Stress Induced Senescencementioning

confidence: 66%

A pro longevity role for cellular senescence

et al. 2019

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“…Apoptosis is the process of programmed cell death, which is considered as a vital component of cell life including normal cell turnover, proper development, and functioning of the immune system, hormone-dependent atrophy et al [20,21]. Numerous studies have recently reported that inappropriate apoptosis (either too little or too much) is a factor involved in various diseases including neurodegenerative diseases, CVD, and cancer [22][23][24][25].…”

Section: Apoptosismentioning

confidence: 99%

Targeting AMP-Activated Protein Kinase in Aging-Related Cardiovascular Diseases

Tian¹,

Ma²,

Yin³

et al. 2020

Aging and disease

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Aging is a pivotal risk factor for developing cardiovascular diseases (CVD) due to the lifelong exposure to various risk factors that may affect the heart and vasculature during aging. AMP-activated protein kinase (AMPK), a serine/threonine protein kinase, is a pivotal endogenous energy regulator that protects against various pathological alterations. In this report, we first introduced the protective mechanisms of AMPK signaling in myocardium, such as oxidative stress, apoptosis, inflammation, autophagy and inflammatory response. Next, we introduced the potential correlation between AMPK and cardiac aging. Then, we highlighted the roles of AMPK signaling in cardiovascular diseases, including myocardial ischemia, cardiomyopathy, and heart failure. Lastly, some potential directions and further perspectives were expanded. The information extends our understanding on the protective roles of AMPK in myocardial aging, which may contribute to the design of drug targets and sheds light on potential treatments of AMPK for aging-related CVD.

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“…In other words, age-related factors could predispose old individuals to develop this common neurodegenerative disease. Impaired mitochondrial functions [1,5], the cell apoptosis [6,7], and the chronic inflammatory process [8] showed commonalities in both PD and normal aged people. Third, the loss of substantia nigra (SN) neurons between normal aging and PD was significant, where the loss of neurons was 28.3% in older controls compared with younger controls, and the loss of pigmented neurons in PD was 73% compared with older controls [9].…”

Section: Introductionmentioning

confidence: 99%

The accelerated aging model reveals critical mechanisms of late-onset Parkinson’s disease

Liu

Bian

et al. 2020

BioData Mining

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Background: Late-onset Parkinson's disease (LOPD) is a common neurodegenerative disorder and lacks disease-modifying treatments, attracting major attentions as the aggravating trend of aging population. There were numerous evidences supported that accelerated aging was the primary risk factor for LOPD, thus pointed out that the mechanisms of PD should be revealed thoroughly based on aging acceleration. However, how PD was triggered by accelerated aging remained unclear and the systematic prediction model was needed to study the mechanisms of PD. Results: In this paper, an improved PD predictor was presented by comparing with the normal aging process, and both aging and PD markers were identified herein using machine learning methods. Based on the aging scores, the aging acceleration network was constructed thereby, where the enrichment analysis shed light on key characteristics of LOPD. As a result, dysregulated energy metabolisms, the cell apoptosis, neuroinflammation and the ion imbalances were identified as crucial factors linking accelerated aging and PD coordinately, along with dysfunctions in the immune system. Conclusions: In short, mechanisms between aging and LOPD were integrated by our computational pipeline.

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Advantages and disadvantages of apoptosis in the aging process

Cited by 50 publications

References 79 publications

A pro longevity role for cellular senescence

A pro longevity role for cellular senescence

Targeting AMP-Activated Protein Kinase in Aging-Related Cardiovascular Diseases

The accelerated aging model reveals critical mechanisms of late-onset Parkinson’s disease

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