Main Points• The Safe Brain Initiative (SBI) is an evidence-based project that enhances patient-centred precision anaesthesia by integrating Patient-Reported Outcome Measures to monitor and prevent postoperative delirium and neurocognitive disorders.• The SBI employs a comprehensive care bundle comprising 18 core recommendations derived from international guidelines, aiming to address potential complications associated with anaesthesia and surgery, such as postoperative pain, nausea, and vomiting.• Preliminary results from the SBI project have shown a notable reduction in postoperative delirium rates and increased awareness among anaesthesia team members regarding patient-related outcomes, indicating the initiative's effectiveness.• The SBI project has gained global traction, with multiple hospitals from various countries participating in the initiative, fostering collaboration, knowledge exchange, and shared experiences to elevate the standards of perioperative care.• By providing healthcare providers anonymous feedback regarding their patients' outcome metrics, they can actively involve patients in their care, leading to better overall health outcomes, increased patient engagement, and reduced costs, contributing to improved patient experiences and continuous quality improvement.