Advantages and disadvantages of various hydrogel scaffold types: A research to improve the clinical conversion rate of loaded MSCs-Exos hydrogel scaffolds

Zhang, Xinyao; Liang, Yi; Luo, Dongmei; Li, Peiwen; Chen, Yurou; Fu, Xinyu; Yue, Yingge; Hou, Ruxia; Liu, Junyu; Wang, Xiangyu

doi:10.1016/j.biopha.2024.117386

Biomedicine & Pharmacotherapy

2024

DOI: 10.1016/j.biopha.2024.117386

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Advantages and disadvantages of various hydrogel scaffold types: A research to improve the clinical conversion rate of loaded MSCs-Exos hydrogel scaffolds

Xinyao Zhang,

Yi Liang,

Dongmei Luo

et al.

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2024

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Cited by 2 publications

References 80 publications

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Fabrication of Antibacterial and Flexible Hydrogels Based on Citric Acid Containing Tannic Acid for Wound Dressing

Seyedzadeh,

Sabzevari,

Kabiri

et al. 2024

Polymers for Advanced Techs

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In this research, a biomonomer based on hydroxyethyl methacrylate, citric acid, and polyethylene glycol (HEMA‐CA‐PEG) was synthesized. After confirming the reaction through 1H‐NMR and FT‐IR tests and obtaining the intended monomer, a flexible hydrogel was synthesized as a wound dressing, and its mechanical properties were evaluated using tensile strength, DMTA, and rheometry tests. This synthesized hydrogel exhibited sufficient mechanical properties. To enhance the efficiency of this hydrogel wound dressing and its effectiveness in facilitating wound healing, tannic acid (TA), as an antibacterial and antioxidant substance, was incorporated into it. In the second phase, antibacterial activity and animal studies were conducted. The comparison of the CA–based hydrogel with and without TA demonstrated that the TA–containing hydrogel achieved more than 99.9% inhibition and elimination of bacteria. The use of CA–based hydrogel with TA shown in treating burns on the backs of rats caused the wound to close after 17 days, and hair growth was observed by the 21st day. This synthesized flexible hydrogel wound dressing, along with suitable mechanical properties, exceptional antibacterial activity, increased granulation tissue formation, re‐epithelialization, angiogenesis, and collagen deposition, showed good performance in wound healing.

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Fabrication of Antibacterial and Flexible Hydrogels Based on Citric Acid Containing Tannic Acid for Wound Dressing

Seyedzadeh,

Sabzevari,

Kabiri

et al. 2024

Polymers for Advanced Techs

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Mesenchymal Stromal Cells for Aging Cartilage Regeneration: A Review

Wu,

Chang,

Ding

et al. 2024

IJMS

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Cartilage degeneration is a key feature of aging and osteoarthritis, characterized by the progressive deterioration of joint function, pain, and limited mobility. Current treatments focus on symptom relief, not cartilage regeneration. Mesenchymal stromal cells (MSCs) offer a promising therapeutic option due to their capability to differentiate into chondrocytes, modulate inflammation, and promote tissue regeneration. This review explores the potential of MSCs for cartilage regeneration, examining their biological properties, action mechanisms, and applications in preclinical and clinical settings. MSCs derived from bone marrow, adipose tissue, and other sources can self-renew and differentiate into multiple cell types. In aging cartilage, they aid in tissue regeneration by secreting growth factors and cytokines that enhance repair and modulate immune responses. Recent preclinical studies show that MSCs can restore cartilage integrity, reduce inflammation, and improve joint function, although clinical translation remains challenging due to limitations such as cell viability, scalability, and regulatory concerns. Advancements in MSC delivery, including scaffold-based approaches and engineered exosomes, may improve therapeutic effectiveness. Potential risks, such as tumorigenicity and immune rejection, are also discussed, emphasizing the need for optimized treatment protocols and large-scale clinical trials to develop effective, minimally invasive therapies for cartilage regeneration.

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Advantages and disadvantages of various hydrogel scaffold types: A research to improve the clinical conversion rate of loaded MSCs-Exos hydrogel scaffolds

Cited by 2 publications

References 80 publications

Fabrication of Antibacterial and Flexible Hydrogels Based on Citric Acid Containing Tannic Acid for Wound Dressing

Fabrication of Antibacterial and Flexible Hydrogels Based on Citric Acid Containing Tannic Acid for Wound Dressing

Mesenchymal Stromal Cells for Aging Cartilage Regeneration: A Review

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