Advantages and limitations of the concept of antidepressant therapy

Freeman, Hugh

doi:10.1016/s0924-977x(97)00063-1

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“…Finally, since all currently available medications for mood disorders exert their therapeutic effects in weeks or months, there is a widely recognized need to find novel drugs that will affect depression much faster [Freeman, 1997;Nestler et al, 2002]. GABAergic drugs, acting both pharmacologically and genomically, might represent a particularly promising area of research in this field.…”

Section: Resultsmentioning

confidence: 99%

Role of GABA in anxiety and depression

2007

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This review assesses the parallel data on the role of gamma-aminobutyric acid (GABA) in depression and anxiety. We review historical and new data from both animal and human experimentation which have helped define the key role for this transmitter in both these mental pathologies. By exploring the overlap in these conditions in terms of GABAergic neurochemistry, neurogenetics, brain circuitry, and pharmacology, we develop a theory that the two conditions are intrinsically interrelated. The role of GABAergic agents in demonstrating this interrelationship and in pointing the way to future research is discussed.

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Section: Resultsmentioning

confidence: 99%