·············································································································································································Sialolithiasis is one of the most common diseases occurring in salivary glands. Sialoliths are characterized by duct closure due to calculus deposits in the salivary gland and ducts, causing edema and pain. Sialolithiasis is most prevalent in the submandibular gland. Most of the sialoliths are small in size (less than 10 mm), and giant sialoliths (greater than 15 mm) are rarely reported. This case reports the successful removal of giant sialolithiasis of 45 mm or more, by an intraoral approach.