Advantages of Nanomedicine in Cancer Therapy: A Review

Wang, Chao; Zhang, Shan

doi:10.1021/acsanm.3c04487

Cited by 21 publications

(9 citation statements)

References 109 publications

(188 reference statements)

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“…After CPT was entrapped in the hydrophobic core of micelles, the volume of the hydrophobic core increases, which results in the expansion of the volume of the drug-loaded micelle system accordingly. The DLS results shown in Figure C demonstrate that the sizes of Lc-TPGS-CPT and TPGS-CPT nanodrugs are in the range of 100–300 nm with a good distribution range (polydispersity index, PDI < 0.2), which will allow them to have long circulation profiles in blood systems because of preventing them from being cleared out by the reticuloendothelial system and promoting efficient accumulation at tumor sites via EPR effects . Compared with TPGS-CPT systems (−3.3 ± 0.6 mV, pH = 7.4), the lower surface charge of Lc-TPGS-CPT nanodrugs (−13.6 ± 1.7 mV, pH = 7.4, Figure D) endowed them with a better mucus-penetrating ability during intestinal absorption, enhancing the oral bioavailability of nanodrugs …”

Section: Resultsmentioning

confidence: 99%

“…According to previous reports, nanomedicines that enter the cancer cells via endocytosis will first form endosomes, which will further fuse with primary lysosomes and transform into secondary lysosomes . Thus, we used lyso-tracker red to label the lysosomes to study the subcellular localization of C6-loaded micelles by using CLSM to visualize MCF-7 cells that were incubated with Lc-TPGS-C6 or TPGS-C6 nanosystems for 1 h. It was found that most C6 signals colocalized with lysosomes, and compared with the TPGS-C6 group, Lc-TPGS-C6-treated cells showed higher PCC values (0.505 ± 0.010 for Lc-TPGS-C6 micelles and 0.345 ± 0.017 for TPGS micelles) (Figure E).…”

Section: Resultsmentioning

confidence: 99%

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Construction of l-Carnitine-Modified TPGS Micelles to Achieve Oral Delivery of Camptothecin and Targeted Anticancer Effects

Chen,

Hong,

Liu

et al. 2024

ACS Appl. Polym. Mater.

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Oral anticancer nanodrugs have recently gained considerable interest due to their advantages of good patient compliance, noninvasiveness, convenience, and repeatable administration. Here, we constructed an L-carnitinemodified α-tocopherol acid poly(ethylene glycol) succinate (Lc-TPGS) oral nanodrug delivery carrier. Studies have shown that Lc-TPGS-based nanodrugs show high stability in simulated gastroenteric fluid and the encapsulation of hydrophobic camptothecin (CPT) in orally administered Lc-TPGS micelles enhances absorption by the intestine through the specific interaction of L-carnitine and the abundantly expressed organic cation transporter 2 (OCTN2). Endocytosed Lc-TPGS-CPT nanodrugs in the intestinal epithelial cells were transcytosed through the endoplasmic reticulum/Golgi pathway into blood circulation in integrity for tumor-targeted delivery. With coumarin 6 or DiR as loaded tracking molecules, in vitro fluorescence imaging and flow cytometry analysis, as well as in vivo imaging, revealed that Lc-TPGS-based nanosystems displayed more efficient cellular uptake and selective accumulation at the tumor site, indicating good tumor-targeting ability. The potential of Lc-TPGS-CPT nanodrugs for effective anticancer activity is demonstrated in vitro. Compared with free CPT and TPGS-CPT nanodrugs, orally administered Lc-TPGS micelles specifically deliver CPT to tumors, efficiently inhibiting the growth of 4T1 tumors with minimal side effects.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Construction of l-Carnitine-Modified TPGS Micelles to Achieve Oral Delivery of Camptothecin and Targeted Anticancer Effects

Chen,

Hong,

Liu

et al. 2024

ACS Appl. Polym. Mater.

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“… 21 Additionally, the unique physicochemical properties of nanodrugs enable sustained drug release, optimizing therapeutic concentrations over time. 22 The surface of these nanoparticles can be functionalized to enhance cellular uptake and improve their ability to evade biological barriers. 23 Moreover, nanodrugs provide opportunities for combination therapies, allowing for the co-delivery of multiple drugs or therapeutic modalities in a single nanoparticle system.…”

Section: Introductionmentioning

confidence: 99%

Polyvinylpyrrolidone Assisted One-Pot Synthesis of Size-Tunable Cocktail Nanodrug for Multifunctional Combat of Cancer

Wang,

Pan,

Chen

et al. 2024

IJN

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Background The in vivo barriers and multidrug resistance (MDR) are well recognized as great challenges for the fulfillment of antitumor effects of current drugs, which calls for the development of novel therapeutic agents and innovative drug delivery strategies. Nanodrug (ND) combining multiple drugs with distinct modes of action holes the potential to circumvent these challenges, while the introduction of photothermal therapy (PTT) can give further significantly enhanced efficacy in cancer therapy. However, facile preparation of ND which contains dual drugs and photothermal capability with effective cancer treatment ability has rarely been reported. Methods In this study, we selected curcumin (Cur) and doxorubicin (Dox) as two model drugs for the creation of a cocktail ND (Cur-Dox ND). We utilized polyvinylpyrrolidone (PVP) as a stabilizer and regulator to prepare Cur-Dox ND in a straightforward one-pot method. Results The size of the resulting Cur-Dox ND can be easily adjusted by tuning the charged ratios. It was noted that both loaded drugs in Cur-Dox ND can realize their functions in the same target cell. Especially, the P-glycoprotein inhibition effect of Cur can synergistically cooperate with Dox, leading to enhanced inhibition of 4T1 cancer cells. Furthermore, Cur-Dox ND exhibited pH-responsive dissociation of loaded drugs and a robust photothermal translation capacity to realize multifunctional combat of cancer for photothermal enhanced anticancer performance. We further demonstrated that this effect can also be realized in 3D multicellular model, which possibly attributed to its superior drug penetration as well as photothermal-enhanced cellular uptake and drug release. Conclusion In summary, Cur-Dox ND might be a promising ND for better cancer therapy.

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“…Nanomedicines is one such approach for improved effectiveness and diagnosis. Nanotechnology-based medicines provide prolonged drug release, targeting effects, overcoming biological barriers, increasing solubility and bioavailability, etc., [ 4 ]. Drug-loaded nanoparticles, or nanomedicine, have been effectively used to actively target cancer at several levels of a tumor’s macroscopic structure and microscopic components by functionalizing a wide range of organic synthetic compounds, ligands, including oligopeptides, hormones, aptamers, antibodies, and vitamins.…”

Section: Introductionmentioning

confidence: 99%

Emerging Trends of Nanomedicines in the Management of Prostate Cancer: Perspectives and Potential Applications

Deshmukh,

Singh,

Harwansh

et al. 2024

Pharmaceutics

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Prostate cancer is one of the most life-threatening disorders that occur in males. It has now become the third most common disease all over the world, and emerging cases and spiking mortality rates are becoming more challenging day by day. Several approaches have been used to treat prostate cancer, including surgery, radiation therapy, chemotherapy, etc. These are painful and invasive ways of treatment. Primarily, chemotherapy has been associated with numerous drawbacks restricting its further application. The majority of prostate cancers have the potential to become castration-resistant. Prostate cancer cells exhibit resistance to chemotherapy, resistance to radiation, ADT (androgen-deprivation therapy) resistance, and immune stiffness as a result of activating tumor-promoting signaling pathways and developing resistance to various treatment modalities. Nanomedicines such as liposomes, nanoparticles, branched dendrimers, carbon nanotubes, and quantum dots are promising disease management techniques in this context. Nanomedicines can target the drugs to the target site and enhance the drug’s action for a prolonged period. They may also increase the solubility and bioavailability of poorly soluble drugs. This review summarizes the current data on nanomedicines for the prevention and treatment of prostate cancer. Thus, nanomedicine is pioneering in disease management.

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Advantages of Nanomedicine in Cancer Therapy: A Review

Cited by 21 publications

References 109 publications

Construction of l-Carnitine-Modified TPGS Micelles to Achieve Oral Delivery of Camptothecin and Targeted Anticancer Effects

Construction of l-Carnitine-Modified TPGS Micelles to Achieve Oral Delivery of Camptothecin and Targeted Anticancer Effects

Polyvinylpyrrolidone Assisted One-Pot Synthesis of Size-Tunable Cocktail Nanodrug for Multifunctional Combat of Cancer

Emerging Trends of Nanomedicines in the Management of Prostate Cancer: Perspectives and Potential Applications

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