Advantages of systematic trunk SPECT/CT to planar bone scan (PBS) in more than 300 patients with breast or prostate cancer

Ferrer, Ludovic; Colombié, Mathilde; Rusu, Darian; Thiec, M. Le; Campion, Loı̈c; Rousseau, Caroline

doi:10.18632/oncotarget.25860

Cited by 18 publications

(9 citation statements)

References 20 publications

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“…Our data revealed that SPECT/CT was superior to BS in all diagnostic parameters. This finding was comparable to the results of previous studies comparing SPECT/CT to BS [4,18,19] in which the sensitivity of targeted SPECT/CT ranges from 90 to 100% and specificity from 78 to 100% compared to planar BS, with the exception of higher specificity of planar BS for R1 than R2, which can be attributed to R1’s greater expertise with a subsequently higher number of TN cases and a lower number of FP cases in BS interpretation for R1 compared to R2. The use of targeted SPECT/CT on suspicious regions increased the number of TP cases at the expense of TN cases.…”

Section: Discussionsupporting

confidence: 92%

Inter-observer variability between readers in detection of bone metastases comparing different modalities; PET/CT, SPECT/CT and planar bone scintigraphy

Bashank

Hussein

Mekawy

et al. 2023

Nuclear Medicine Communications

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Objective To assess the inter-observer variability between readers in the detection of bone metastases for different modalities [planar bone scintigraphy (BS), single photon emission computed tomography/ computed tomography (SPECT/CT), and fluorine-18 fluorodeoxyglucose positron emission tomography/ computed tomography (PET/CT) (F-18 FDG PET/CT)].Methods Patients with known primary tumors referred for metastatic workup either by F-18 FDG PET/CT or conventional planar BS and SPECT/CT were enrolled in this prospective study. The three modalities (BS, SPECT/CT, and PET/CT) were acquired for each patient. Interpretation was done by two independent nuclear medicine physicians separately and blindly; reader 1 (R1) and reader 2 (R2). A three-point subjective scale was used (1 = negative for bone metastases, 2 = equivocal, and 3 = positive). The findings were compared to the final patient status based on clinical and radiological follow-up for at least 6 months. The Kappa test was used to assess the degree of agreement between readers in their interpretation of each modality.Results A total of 54 patients (39 females and 15 males, ages 26-76; mean: 54.7 ± 12) were eligible for this study. Fair agreement 0.372 between R1 and R2 in interpretation of BS was noticed that improved to 0.847 after addition of SPECT/CT. Perfect agreement was achieved between R1 and R2 while interpreting PET/CT images (kappa = 0.964, P < 0.001).Conclusion F-18 FDG PET/CT significantly improved the inter-observer variability between readers, allowing for better diagnosis of bone metastases in known cancer patients. Also, it was superior to BS and SPECT/CT in the detection of bone metastases. Nucl Med Commun

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Section: Discussionsupporting

confidence: 92%

Inter-observer variability between readers in detection of bone metastases comparing different modalities; PET/CT, SPECT/CT and planar bone scintigraphy

Bashank

Hussein

Mekawy

et al. 2023

Nuclear Medicine Communications

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“…This technique has the potential to replace WB planar scintigraphy in, for example, WB bone scanning 2,3 . WB‐SPECT/CT can be clinically useful in increasing diagnostic confidence when evaluating bone metastases (BM) and when assessing suspicious or equivocal lesions via WB planar scintigraphy in cancer cases, as attested by a number of studies 4–6 …”

Section: Introductionmentioning

confidence: 99%

Optimization of ^99mTc whole‐body SPECT/CT image quality: A phantom study

Alqahtani

Willowson

Constable

et al. 2022

J Applied Clin Med Phys

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Purpose Investigate the impact of acquisition time and reconstruction parameters on single‐photon emission computed tomography/computed tomography (SPECT/CT) image quality with the ultimate aim of finding the shortest possible acquisition time for clinical whole‐body SPECT/CT (WB‐SPECT/CT) while maintaining image quality Methods The National Electrical Manufacturers Association (NEMA) image quality measurements were performed on a SPECT/CT imaging system using a NEMA International Electrotechnical Commission (IEC) phantom with spherical inserts of varying diameter (10–37 mm), filled with 99mTc in activity sphere‐to‐background concentration ratio of 8.5:1. A gated acquisition was acquired and binned data were summed to simulate acquisitions of 15, 8, and 3 s per projection angle. Images were reconstructed on a Hermes (HERMES Medical Solutions AB, Stockholm, Sweden) workstation using eight subsets and between 4 and 24 iterations of the three‐dimensional (3D) ordered subset expectation maximization (OSEM) algorithm. Reconstructed images were post‐smoothed with 3D Gaussian filter ranging from 0 to 12 mm full‐width at half maximum (FWHM). Contrast recovery, background variability, and contrast‐to‐noise ratio were evaluated Results As expected, the spheres were more clearly defined as acquisition time and count statistics improved. The optimal iteration number and Gaussian filter were determined from the contrast recovery convergence and level of noise. Convergence of contrast recovery was observed at eight iterations while 12 iterations yielded stabilized values at all acquisition times. In addition, it was observed that applying 3D Gaussian filter of 8–12 mm FWHM suppressed the noise and mitigated Gibbs artifacts. Background variability was larger for small spheres than larger spheres and the noise decreased when acquisition time became longer. A contrast‐to‐noise ratio >5 was reached for the two smallest spheres of 10 and 13 mm at acquisition times of 8 s Conclusion Optimized reconstruction parameters preserved image quality with reduce acquisition time in present study. This study suggests an optimal protocol for clinical 99mTc SPECT/CT can be reached at 8 s per projection angle, with data reconstructed using 12 iterations and eight subset of the 3D OSEM algorithm and 8 mm Gaussian post‐filter.

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“…Disease prevalence could impact diagnostic performance indices [24]. Also, treating equivocal lesion as malignant (pessimistic analysis) could shift the values of sensitivity and speci city [25,26].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Performance of SPECT/CT Versus Diffusion-Weighted Mri in Characterization of Indeterminate Osseous Lesions Detected on Bone Scan

Abdelhafez

Khalil

Atta

et al. 2021

Preprint

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Background: Characterization of solitary osseous lesions on planar bone scintigraphy (PBS) is challenging. In this pilot study, we aimed to explore the diagnostic performance of 99mTc-MDP bone scintigraphy using SPECT/CT in comparison to magnetic resonance imaging including diffusion-weighted imaging (MR-DWI) in patients with solitary indeterminate osseous lesions detected on PBS. Methods: This pilot study prospectively recruited 46 cancer patients who underwent PBS, with a finding of a solitary osseous lesion that was deemed indeterminate by two nuclear medicine physicians not involved in subsequent reading. A targeted SPECT/CT and MR-DWI were read independently by two nuclear medicine physicians and two radiologists, respectively, on a 5-point probability score. The final diagnosis of disease status was formulated from subsequent clinical/imaging follow-up within six months. Results: Agreement between SPECT/CT readers was 0.73 (95% confidence interval [CI]:0.51-0.85) and 0.99 (95%CI:0.99-1.00) between MR-DWI readers. According to the follow-up, 16/46 patients proved to have osseous metastasis. The area under the curve (AUC) from ROC analysis was 0.79 (95%CI:0.65-93) for SPECT/CT and 0.73 (95%CI:0.57-0.89) for MR-DWI. No statistically significant difference was noted regarding sensitivity or specificity. MR-DWI was more accurate for lesions located in the appendicular skeleton (n=17; AUC=0.92,95%CI:0.68-1.0) compared to axial lesions (n=29; AUC=0.65,95%CI:0.45-0.81). The performance of SPECT/CT was comparable for both sites. Diagnostic indices from both modalities were comparable for sclerotic and non-sclerotic lesions on the CT part of SPECT/CT.Conclusions: In this exploratory report, no significant difference was seen in the overall diagnostic performance between SPECT/CT and MR-DWI for characterization of solitary indeterminate osseous lesions depicted on PBS. MR-DWI results were more reproducible; however, the overall accuracy of MR-DWI varied according to lesion site, density patterns on CT, and the primary tumor type. Such differences were less obvious with SPECT/CT.

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Advantages of systematic trunk SPECT/CT to planar bone scan (PBS) in more than 300 patients with breast or prostate cancer

Cited by 18 publications

References 20 publications

Inter-observer variability between readers in detection of bone metastases comparing different modalities; PET/CT, SPECT/CT and planar bone scintigraphy

Inter-observer variability between readers in detection of bone metastases comparing different modalities; PET/CT, SPECT/CT and planar bone scintigraphy

Optimization of ^99mTc whole‐body SPECT/CT image quality: A phantom study

Diagnostic Performance of SPECT/CT Versus Diffusion-Weighted Mri in Characterization of Indeterminate Osseous Lesions Detected on Bone Scan

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Advantages of systematic trunk SPECT/CT to planar bone scan (PBS) in more than 300 patients with breast or prostate cancer

Cited by 18 publications

References 20 publications

Inter-observer variability between readers in detection of bone metastases comparing different modalities; PET/CT, SPECT/CT and planar bone scintigraphy

Inter-observer variability between readers in detection of bone metastases comparing different modalities; PET/CT, SPECT/CT and planar bone scintigraphy

Optimization of 99mTc whole‐body SPECT/CT image quality: A phantom study

Diagnostic Performance of SPECT/CT Versus Diffusion-Weighted Mri in Characterization of Indeterminate Osseous Lesions Detected on Bone Scan

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Optimization of ^99mTc whole‐body SPECT/CT image quality: A phantom study