“…21 Few prospective randomised controlled trials (RCTs) exist but have suggested improved rates of first-pass punctures, midline location and trends towards fewer procedure-related complications, when compared with anatomical landmarkbased PT. 14,16,22,23 In direct comparison with bronchoscopy-aided PT, Ravi et al in a prospective, single-centre randomised control trial (RCT) of 74 PT-related complications rates range from 2.1% to more than 20%. These are usually early and minor, but significant complications related to haemorrhage, false tract formation and hypoxia from airway obstruction can occur.…”