Advantages of using toothpaste containing propolis and plant oils for gingivitis prevention and oral cavity hygiene in cleft lip/palate patients

Machorowska-Pieniążęk, Agnieszka; Morawiec, Tadeusz; Olek, Marcin; Mertas, Anna; Aebisher, David; Bartusik‐Aebisher, Dorota; Cieślar, Grzegorz; Kawczyk‐Krupka, Aleksandra

doi:10.1016/j.biopha.2021.111992

Cited by 18 publications

(13 citation statements)

References 44 publications

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“…A few toothpastes with propolis as an active ingredient are already commercially available. They have been tested in vitro [ 26 , 39 ] or in clinical trials [ 41 , 42 ]. A toothpaste with Polish propolis has been proven to be effective in the gingivitis prevention of patients with oral clefts [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

“…They have been tested in vitro [ 26 , 39 ] or in clinical trials [ 41 , 42 ]. A toothpaste with Polish propolis has been proven to be effective in the gingivitis prevention of patients with oral clefts [ 41 ]. A toothpaste preparation with EEP of green Brazilian propolis reduced biofilm and inflammation in patients with dental implants rehabilitation [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

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In Vitro Study on Green Propolis as a Potential Ingredient of Oral Health Care Products

et al. 2022

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Propolis is increasingly being discussed as an alternative to commonly used antiseptics. This in vitro study focused on the ethanolic extract of green Brazilian propolis (EEPg) as an additive in an oral health care product. We investigated (i) a potential inflammation-modulation activity of EEPg when a periodontal or Candida biofilm was exposed to monocytic (MONO-MAC-6) cells, (ii) the adhesion of oral pathogens to gingival keratinocytes and (iii) the antimicrobial and antibiofilm effect of different toothpaste formulations. EEPg decreased the levels of interleukin (IL)-1β and increased IL-10 in MONO-MAC cells challenged with a periodontal biofilm. In contact with TIGK cells, EEPg reduced the numbers of adherent Porphyromonas gingivalis to 0.5% but did not affect the adhesion of Candida albicans. The frequent brushing of a cariogenic biofilm with a toothpaste supplemented with EEPg reduced the surface microhardness loss of enamel specimens. Mixing an experimental erythritol toothpaste with 25 and 50 mg/mL of EEPg confirmed the antibacterial activity of EEPg against oral bacteria and particularly inhibited periodontal biofilm formation. The suggested toothpaste formulations seem to have potential in the prevention of caries, gingivitis and periodontitis and should be evaluated in further in vitro research and in clinical trials.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

In Vitro Study on Green Propolis as a Potential Ingredient of Oral Health Care Products

et al. 2022

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“…A large number of in vitro and in vivo anti‐inflammatory experiments have been successfully conducted to evaluate the anti‐inflammatory effect of rosemary extract, demonstrating its predominant potential effects on gingivitis (Machorowska‐Pieniążek et al., 2021), arthritis (Wei et al., 2021), pleurisy (da Rosa et al., 2013), colitis (Yilmaz et al., 2022), neuroprotection (Khalid et al., 2020), and other related inflammatory diseases. Notably, the animal models of in vivo inflammation tests mainly used drug‐induced paw edema of experimental mice (Grigore et al., 2015).…”

Section: Biological Activities Of Rosemary Extractmentioning

confidence: 99%

Rosemary: Unrevealing an old aromatic crop as a new source of promising functional food additive—A review

Qiu,

Wang,

Duan

et al. 2024

Comp Rev Food Sci Food Safe

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Rosemary (Rosmarinus officinalis L.) is one of the most famous spice plants belonging to the Lamiaceae family as a remarkably beautiful horticultural plant and economically agricultural crop. The essential oil of rosemary has been enthusiastically welcome in the whole world for hundreds of years. Now, it is wildly prevailing as a promising functional food additive for human health. More importantly, due to its significant aroma, food, and nutritional value, rosemary also plays an essential role in the food/feed additive and food packaging industries. Modern industrial development and fundamental scientific research have extensively revealed its unique phytochemical constituents with biologically meaningful activities, which closely related to diverse human health functions. In this review, we provide a comprehensively systematic perspective on rosemary by summarizing the structures of various pharmacological and nutritional components, biologically functional activities and their molecular regulatory networks required in food developments, and the recent advances in their applications in the food industry. Finally, the temporary limitations and future research trends regarding the development of rosemary components are also discussed and prospected. Hence, the review covering the fundamental research advances and developing prospects of rosemary is a desirable demand to facilitate their better understanding, and it will also serve as a reference to provide many insights for the future promotion of the research and development of functional foods related to rosemary.

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“…PDT has a positive effect in significantly reducing the periodontal microbial load [62]. The anti-inflammatory and antibacterial action were possible due to the effect of toothpaste containing Polish propolis and plant oils on oral cavity health in patients with oral cleft treated orthodontically [63].…”

Section: Naturally Occurring Photosensitizers In Pdtmentioning

confidence: 99%

Some Natural Photosensitizers and Their Medicinal Properties for Use in Photodynamic Therapy

et al. 2022

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Despite significant advances in early diagnosis and treatment, cancer is one of the leading causes of death. Photodynamic therapy (PDT) is a therapy for the treatment of many diseases, including cancer. This therapy uses a combination of a photosensitizer (PS), light irradiation of appropriate length and molecular oxygen. The photodynamic effect kills cancer cells through apoptosis, necrosis, or autophagy of tumor cells. PDT is a promising approach for eliminating various cancers but is not yet as widely applied in therapy as conventional chemotherapy. Currently, natural compounds with photosensitizing properties are being discovered and identified. A reduced toxicity to healthy tissues and a lower incidence of side effects inspires scientists to seek natural PS for PDT. In this review, several groups of compounds with photoactive properties are presented. The use of natural products has been shown to be a fruitful approach in the discovery of novel pharmaceuticals. This review focused on the anticancer activity of furanocoumarins, polyacetylenes, thiophenes, tolyporphins, curcumins, alkaloid and anthraquinones in relation to the light-absorbing properties. Attention will be paid to their phototoxic and anti-cancer effects on various types of cancer.

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Advantages of using toothpaste containing propolis and plant oils for gingivitis prevention and oral cavity hygiene in cleft lip/palate patients

Cited by 18 publications

References 44 publications

In Vitro Study on Green Propolis as a Potential Ingredient of Oral Health Care Products

In Vitro Study on Green Propolis as a Potential Ingredient of Oral Health Care Products

Rosemary: Unrevealing an old aromatic crop as a new source of promising functional food additive—A review

Some Natural Photosensitizers and Their Medicinal Properties for Use in Photodynamic Therapy

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