Advantages of Whole Genome Sequencing in Mitigating the Helicobacter pylori Antimicrobial Resistance Problem

Fauzia, Kartika Afrida; Alfaray, Ricky Indra; Yamaoka, Yoshio

doi:10.3390/microorganisms11051239

Cited by 6 publications

(1 citation statement)

References 29 publications

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“…Several NGS-based technologies are even affordable in low-income countries, and the high concordance between mutations and phenotypic drug resistance makes them a desirable option for monitoring genotypic markers of antibiotic resistance in H. pylori [ 23 , 24 , 59 , 62 ]. The combination of WGS and phenotypic methodologies, according to some experts, provides a more comprehensive approach to antimicrobial resistance surveillance [ 63 ].…”

Section: Detection Of Antibiotic Resistancementioning

confidence: 99%

Drug-Resistant Helicobacter pylori: Diagnosis and Evidence-Based Approach

Jearth,

Rath,

Chatterjee

et al. 2023

Diagnostics

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Helicobacter pylori (H. pylori) is the most common chronic bacterial infection, affecting approximately half of the world’s population. H. pylori is a Class I carcinogen according to the World Health Organization, and the International Agency for Research on Cancer (IARC) has linked it to 90% of stomach cancer cases worldwide. The overall pattern points to a yearly reduction in eradication rates of H. pylori with the likelihood of success further decreasing after each unsuccessful therapeutic effort. Antimicrobial resistance in Helicobacter pylori is a major public health concern and is a predominant cause attributed to eradication failure. As a result, determining H. pylori’s antibiotic susceptibility prior to the administration of eradication regimens becomes increasingly critical. Detecting H. pylori and its antimicrobial resistance has traditionally been accomplished by time-consuming culture and phenotypic drug susceptibility testing. The resistance of H. pylori to different antibiotics is caused by various molecular mechanisms, and advances in sequencing technology have greatly facilitated the testing of antibiotic susceptibility to H. pylori. This review will summarize H. pylori antibiotic resistance patterns, mechanisms, and clinical implications. We will also review the pros and cons of current antibiotic susceptibility testing methods. Along with a comparison of tailored susceptibility-guided regimens and empirical therapy based on the latest evidence, an evidence-based approach to such situations will be explored.

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