Adventitial Fibroblasts

Increased Migration of Vascular Adventitial Fibroblasts from Spontaneously Hypertensive Rats

“…The vascular wall is composed of phenotypically heterogeneous subpopulations of endothelial cells, VSMCs and fibroblasts. Recent studies have demonstrated that neointimal formation may be the result of fibroblast differentiation and migration (22). According to our recent observation, Ang II can induce phenotypic transition of vascular AFs to myofibroblasts and p38 MAPK signaling is involved in this differentiation as well (23).…”

Perivascular Adipose Tissue–Derived Complement 3 Is Required for Adventitial Fibroblast Functions and Adventitial Remodeling in Deoxycorticosterone Acetate–Salt Hypertensive Rats

“…10,11 Multiple lines of evidence suggest that vascular adventitial fibroblasts (AFs), the major cell component of adventitia, play a vital role in regulating the structure and function of blood vessels. 12,13 Previous studies 14,15 indicated that numerous active cytokines induce AF migration, which may be associated with the pathogenesis of neointimal formation. Although AFs are in closer proximity to PVAT compared with VSMCs, little attention has been devoted to the role of PVAT-derived factors in the regulation of AF function.…”

Association of atherosclerotic risk factors with carotid adventitial thickness assessed by ultrasonography

“…This result is in agreement with published data and shows that the activation was more modest for adventitial cells compared with intimal and medial cells under conditions of low-grade inflammation and that this is relevant to atherosclerosis. 9 In experimental models, 43 the proliferating potential observed in adventitial cells was also lower than in the intima and media layers. This might explain the significant, but relatively weaker, correlation between leukocyte count and AT than between leukocyte count and IMT.…”

“…Substantially less attention has been paid to the adventitia, the external layer of the carotid artery wall, which has long been regarded as only a vessel-supporting structure. Recently, increasing evidence [8][9][10][11][12] has emerged that adventitial cells are involved in the pathogenesis and development of atherosclerosis.…”