Adventures in the Chemistry of Multicomponent and Domino Reactions

Abstract

The present personalized account summarizes various cyclization reactions, including multicomponent and domino processes, which are directed towards the synthesis of complex heterocyclic products. Reactions include, for example, various domino Knoevenagel /cyclization reactions, formal [3+3] cyclizations of pyridinium salts and of thioxindoles with fluoroaroyl chlorides, cyclizations of heterocyclic enamines with diimines and triazines, formal [3+3] cyclizations of 2,4,6‐tris(trifluoromethyl)‐1,3,5‐triazine with 1,3‐bis(silyloxy)‐1,3‐butadienes and domino [4+2] / retro [4+2] reactions of 2‐ethynylpyridines with electron‐rich dienes.