Adventures in Translocation: Studies of the Translocator Protein (TSPO) 18 kDa

Abstract

The 18 kDa translocator protein (TSPO) is an evolutionarily conserved transmembrane protein found embedded in the outer mitochondrial membrane. A secondary target for the benzodiazepine diazepam, TSPO has been a protein of interest for researchers for decades, particularly owing to its well-established links to inflammatory conditions in the central and peripheral nervous systems. It has become a key biomarker for assessing microglial activation using positron emission tomography (PET) imaging in patients with diseases ranging from atherosclerosis to Alzheimer's disease. This Account describes research published by our group over the past 15 years surrounding the development of TSPO ligands and their use in probing the function of this high-value target.

Celebrating RACI and Academy of Science Awards 2020–2021

“…It has become a key biomarker for assessing microglial activation using PET imaging in patients with diseases ranging from atherosclerosis to Alzheimer's disease. [1] Danielle Skropeta (University of Wollongong) received the RACI's 2020 Margaret Sheil Leadership Award. Together with associates at the University of Wollongong and the Illawarra Health and Medical Research Institute, she contributes an Account on sialyltransferase (ST) inhibitors as potential anticancer agents.…”