Adverse birth outcomes are associated with circulating matrix metalloproteinases among pregnant women in Puerto Rico

Kim, Christine; Cathey, Amber L.; Watkins, Deborah J.; Mukherjee, Bhramar; Rosario-Pabón, Zaira; Vélez-Vega, Carmen M.; Cordero, José F.; Meeker, John D.

doi:10.1016/j.jri.2023.103991

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Nfκb Signal Pathway In Normal Gestation and Pe1

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2024

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“…Furthermore, higher NFκB expression in the first trimester is associated with increased MMP expression. MMPs are important extracellular matrix (ECM) remodeling proteinases that control uterine remodeling, a process that is essential for healthy pregnancies 26 . High MMP-9 levels promote uterine ECM degradation and relax intercellular connections, promoting extravillous trophoblast cells to invade and uterine spiral artery remodeling 27 28 .…”

Section: Nfκb Signal Pathway In Normal Gestation and Pementioning

confidence: 99%

The NFκB Signaling Pathway Is Involved in the Pathophysiological Process of Preeclampsia

Li,

Zhu,

et al. 2024

Geburtshilfe Frauenheilkd

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The high prevalence of preeclampsia (PE) is a major cause of maternal and fetal mortality and affects the long-term prognosis of both mother and baby. Termination of pregnancy is currently the only effective treatment for PE, so there is an urgent need for research into its pathogenesis and the development of new therapeutic approaches. The NFκB family of transcription factors has an essential role in inflammation and innate immunity. In this review, we summarize the role of NFκB in normal and preeclampsia pregnancies, the role of NFκB in existing treatment strategies, and potential NFκB treatment strategies.

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Section: Nfκb Signal Pathway In Normal Gestation and Pementioning

confidence: 99%