Adverse Cardiac Manifestations Following Dextropropoxyphene Overdose: Can Naloxone Be Helpful?

Acute reversible cardiac involvement associated with systemic capillary leak syndrome

“…Cardiac contractility is conserved. Some authors describe a favorable effect of intravenous naloxone on hypotension and shock [2]. The abnormalities are completely regressive within 3 days and may reoccur at the next attack.…”

“…Sir: Clarkson's syndrome is an infrequent disorder characterized by gammopathy of undetermined significance [1] and episodic hypovolemic collapse due to sudden plasma shifts from intravascular compartments because of increased capillary permeability [2,3]. The other techniques to measure pulsus paradoxus are unsuitable in this situation.…”

Ventricular Dysrhythmias Associated with Poisoning and Drug Overdose: A 10-Year Review of Statewide Poison Control Center Data from California

“…Tramadol toxicity has been reported to cause both QRS and QT prolongation [45]. Propoxyphene is well known to cause sodium channel blockade [46].…”

Dextropropoxyphene and the cardiovascular system: About two cases of acute poisoning with cardiac conduction abnormalities

“…Naloxone has shown its incapacity to reverse DP cardiotoxicity 7 in vitro and in some clinical observations. 8 On isolated Purkinje fibers, DP and NP have produced a dose-dependent inhibition of V max , a shortening of the action potential duration (APD), and a decrease of the effective refractory period (ERP) without modifying the ERP/APD ratio. 9 On an isolated guinea pig atrium, they have exerted negative inotropic and chronotropic actions 9 that have been confirmed in vivo on pentobarbital-anesthetized pigs.…”