Adverse childhood experiences and early life inflammation in the Avon longitudinal study of parents and children

Lacey, Rebecca; Bartley, Mel; Kelly-Irving, Michelle; Bevilacqua, Leonardo; Iob, Eleonora; Kelly, Yvonne; Howe, Laura D

doi:10.1016/j.psyneuen.2020.104914

Cited by 32 publications

(26 citation statements)

References 58 publications

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“…Experiencing any type of trauma in early childhood seems to lead to elevated peripheral levels of TNF-α and IL-6 in adults, while being a victim of sexual abuse only elevates peripheral levels of TNF-α in adulthood [77]. The nature of the relationship between early childhood trauma and cytokine levels also seems to depend on a number of factors, such as the nature of the trauma, applied diagnostic categories, age, menopause, and gender [77][78][79].…”

Section: The Role Of Early Childhood Traumamentioning

confidence: 99%

The Role of Cytokines in the Pathogenesis of Schizophrenia

Dawidowski

Górniak

Podwalski

et al. 2021

JCM

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Schizophrenia is a chronic mental illness of unknown etiology. A growing and compelling body of evidence implicates immunologic dysfunction as the key element in its pathomechanism. Cytokines, whose altered levels have been increasingly reported in various patient populations, are the major mediators involved in the coordination of the immune system. The available literature reports both elevated levels of proinflammatory as well as reduced levels of anti-inflammatory cytokines, and their effects on clinical status and neuroimaging changes. There is evidence of at least a partial genetic basis for the association between cytokine alterations and schizophrenia. Two other factors implicated in its development include early childhood trauma and disturbances in the gut microbiome. Moreover, its various subtypes, characterized by individual symptom severity and course, such as deficit schizophrenia, seem to differ in terms of changes in peripheral cytokine levels. While the use of a systematic review methodology could be difficult due to the breadth and diversity of the issues covered in this review, the applied narrative approach allows for a more holistic presentation. The aim of this narrative review was to present up-to-date evidence on cytokine dysregulation in schizophrenia, its effect on the psychopathological presentation, and links with antipsychotic medication. We also attempted to summarize its postulated underpinnings, including early childhood trauma and gut microbiome disturbances, and propose trait and state markers of schizophrenia.

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Section: The Role Of Early Childhood Traumamentioning

confidence: 99%

The Role of Cytokines in the Pathogenesis of Schizophrenia

Dawidowski

Górniak

Podwalski

et al. 2021

JCM

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“…Recent work has also demonstrated a significant association between adverse childhood experiences and CRP in adolescents (Kliewer and Robins, 2021) and an association between childhood victimization and CRP in 18-yearold females, but not males (Baldwin et al, 2018). In another study, Lacey et al (2020) studied how specific adverse childhood experiences affected inflammation and found that 9-yearolds who had experienced parental separation had statistically elevated IL-6 compared to those who had experienced other types of adverse childhood experiences. Other research examining specific types of adverse childhood experiences includes work examining the impact of childhood maltreatment, defined as physical abuse, physical neglect, emotional abuse, emotional neglect, and sexual abuse (Bernstein et al, 2003;Mauritz et al, 2013).…”

Section: Harsh Family Environments and Adverse Childhood Experiencesmentioning

confidence: 99%

Immune and Epigenetic Pathways Linking Childhood Adversity and Health Across the Lifespan

et al. 2021

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Childhood adversity is associated with a host of mental and physical health problems across the lifespan. Individuals who have experienced childhood adversity (e.g., child abuse and neglect, family conflict, poor parent/child relationships, low socioeconomic status or extreme poverty) are at a greater risk for morbidity and premature mortality than those not exposed to childhood adversity. Several mechanisms likely contribute to the relationship between childhood adversity and health across the lifespan (e.g., health behaviors, cardiovascular reactivity). In this paper, we review a large body of research within the field of psychoneuroimmunology, demonstrating the relationship between early life stress and alterations of the immune system. We first review the literature demonstrating that childhood adversity is associated with immune dysregulation across different indices, including proinflammatory cytokine production (and its impact on telomere length), illness and infection susceptibility, latent herpesvirus reactivation, and immune response to a tumor. We then summarize the growing literature on how childhood adversity may alter epigenetic processes. Finally, we propose future directions related to this work that have basic and applied implications.

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“…It is important to note that inflammatory markers observed in children are dependent of the ACE (maternal mental health problems and physical abuse or parental conflict and emotional abuse) and can affect differently girls and boys [ 140 ]. In a UK Household Longitudinal Study, it was demonstrated that the inflammatory system and, to a lesser extent, the metabolic system consistently drove (across age groups and gender) the observed values of the Biological Health Score independently of social status and exposure [ 141 ].…”

Section: Hypothesis Of Different Mechanisms Leading To MDmentioning

confidence: 99%

Early Life Exposure to Food Contaminants and Social Stress as Risk Factor for Metabolic Disorders Occurrence?—An Overview

Guzylack‐Piriou

Ménard

2021

Biomolecules

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The global prevalence of obesity has been increasing in recent years and is now the major public health challenge worldwide. While the risks of developing metabolic disorders (MD) including obesity and type 2 diabetes (T2D) have been historically thought to be essentially driven by increased caloric intake and lack of exercise, this is insufficient to account for the observed changes in disease trends. Based on human epidemiological and pre-clinical experimental studies, this overview questioned the role of non-nutritional components as contributors to the epidemic of MD with a special emphasis on food contaminants and social stress. This overview examines the impact of early life adverse events (ELAE) focusing on exposures to food contaminants or social stress on weight gain and T2D occurrence in the offspring and explores potential mechanisms leading to MD in adulthood. Indeed, summing up data on both ELAE models in parallel allowed us to identify common patterns that appear worthwhile to study in MD etiology. This overview provides some evidence of a link between ELAE-induced intestinal barrier disruption, inflammation, epigenetic modifications, and the occurrence of MD. This overview sums up evidence that MD could have developmental origins and that ELAE are risk factors for MD at adulthood independently of nutritional status.

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Adverse childhood experiences and early life inflammation in the Avon longitudinal study of parents and children

Cited by 32 publications

References 58 publications

The Role of Cytokines in the Pathogenesis of Schizophrenia

The Role of Cytokines in the Pathogenesis of Schizophrenia

Immune and Epigenetic Pathways Linking Childhood Adversity and Health Across the Lifespan

Early Life Exposure to Food Contaminants and Social Stress as Risk Factor for Metabolic Disorders Occurrence?—An Overview

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