Adverse childhood experiences and risk of type 2 diabetes: A systematic review and meta-analysis

Huang, Hao; Yan, Peipei; Shan, Zhilei; Chen, Sijing; Li, Moying; Luo, Cheng; Gao, Hui; Hao, Liping; Liu, Liegang

doi:10.1016/j.metabol.2015.08.019

Cited by 199 publications

(152 citation statements)

References 78 publications

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“…This approach has a rich research history supporting the dose-response effect of cumulative adversity and its impact on physical, mental and substance use disorders. The interested reader is directed to one of several systematic or meta-analytic reviews available on this concept (Danese and McEwen 2012; Danese and Tan 2014; Huang et al 2015; Kalmakis and Chandler 2015; Su et al 2015). …”

Section: Discussionmentioning

confidence: 99%

Early life adversity influences stress response association with smoking relapse

et al. 2017

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Rationale We examined the hypothesis that stress-related blunting of cortisol in smokers is particularly pronounced in those with history of severe life adversity. Objectives The 2 aims of this study were first to examine hormonal, craving, and withdrawal symptoms during ad libitum smoking and after the first 24 hours of abstinence in smokers who experienced high or low levels of adversity. Secondly, we sought to examine the relationship between adversity and HPA hormones to predict relapse during the first month of a smoking cessation attempt. Methods Hormonal and self-report measures were collected from 103 smokers (49 women) during ad libitum smoking and after the first 24 hours of abstinence. Hypothalamic-pituitary-adrenal (HPA) hormones were measured during baseline rest and in response to acute stress in both conditions. All smokers were interested in smoking cessation, and we prospectively used stress response measures to predict relapse during the first four weeks of the smoking cessation attempt. Results The results showed that high adversity was associated with higher distress and smoking withdrawal symptoms. High level of early life adversity was associated with elevated HPA activity, which was found in both salivary and plasma cortisol. Enhanced adrenocorticotropic hormone (ACTH) stress response was evident in high adversity but not in low adversity relapsers. Conclusions This study demonstrated that early life adversity is associated with stress-related HPA responses. The study also demonstrated that, among smokers who experienced a high level of life adversity, heightened ACTH and cortisol responses were linked with increased risk for smoking relapse.

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Section: Discussionmentioning

confidence: 99%

Early life adversity influences stress response association with smoking relapse

et al. 2017

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“…A recent meta-analysis also noted insufficient data to draw conclusions about sex-related differences based on adverse childhood events exposure and T2DM. 47 Taken together, these data suggest large gaps in our knowledge and that a more rigorous examination of sex differences in the relation between childhood adversity and cardiometabolic outcomes is warranted.…”

Section: Sexmentioning

confidence: 95%

Childhood and Adolescent Adversity and Cardiometabolic Outcomes: A Scientific Statement From the American Heart Association

Suglia¹,

Koenen²,

et al. 2018

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Adverse experiences in childhood and adolescence, defined as subjectively perceived threats to the safety or security of the child's bodily integrity, family, or social structures, are known to be associated with cardiometabolic outcomes over the life course into adulthood. This American Heart Association scientific statement reviews the scientific literature on the influence of childhood adversity on cardiometabolic outcomes that constitute the greatest public health burden in the United States, including obesity, hypertension, type 2 diabetes mellitus, and cardiovascular disease. This statement also conceptually outlines pathways linking adversity to cardiometabolic health, identifies evidence gaps, and provides suggestions for future research to inform practice and policy. We note that, despite a lack of objective agreement on what subjectively qualifies as exposure to childhood adversity and a dearth of prospective studies, substantial evidence documents an association between childhood adversity and cardiometabolic outcomes across the life course. Future studies that focus on mechanisms, resiliency, and vulnerability factors would further strengthen the evidence and provide much-needed information on targets for effective interventions. Given that childhood adversities affect cardiometabolic health and multiple health domains across the life course, interventions that ameliorate these initial upstream exposures may be more appropriate than interventions remediating downstream cardiovascular disease risk factor effects later in life.

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“…Early life stressors are associated with increased risks of adverse health behaviors such as smoking and alcohol abuse, which may contribute to increased asthma risk. [18] Alternatively, prior studies have reported associations of adverse childhood experiences with a myriad of chronic disorders including ischemic heart disease [2–5, 7], diabetes [3–5, 7, 8], obesity [2, 31], and respiratory disorders [3–5, 11, 18] which may contribute to increased risks of asthma. Finally, mouse models illustrate histopathological inflammatory changes of the respiratory tract when exposed to stressors.…”

Section: Discussionmentioning

confidence: 99%

“…[1–6] Exposure to childhood adversity has been found to be associated with poor health during adulthood manifesting in the leading causes of adult morbidities, such as coronary heart disease [2–5, 7], stroke [3], diabetes [3–5, 7, 8], migraine [4, 9], chronic fatigue [4], psychiatric disorders [3, 10], and asthma [3–5, 11]. Asthma is a chronic inflammatory disease of the airways that can develop during childhood or adulthood causing significant burden and reduced quality of life.…”

Section: Introductionmentioning

confidence: 99%

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Childhood abuse and adult-onset asthma among Peruvian women

et al. 2017

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Objective Childhood abuse has been found to be associated with adult-onset asthma; however, this association has not been studied in low and middle income countries with a high burden of gender-based violence, including childhood abuse. We examined the odds of asthma diagnosed at age 18 or older in relation to history of physical and sexual abuse among Peruvian pregnant women. Methods This cross-sectional study collected demographic characteristics, history of abuse and asthma diagnoses from 3081 pregnant women. Logistic regression procedures estimated adjusted odds ratios and 95% confidence intervals (aOR,[95%CI]) for asthma diagnoses in relation to abuse. Results Overall, 71% of women reported a history of abuse (<18 years), and asthma was diagnosed among 2.6% of cohort participants. The prevalence of physical only, sexual only and both physical and sexual childhood abuse was 38%, 8% and 24%, respectively. History of physical only (1.16,[0.63–2.17]), sexual only (2.11,[0.92–4.84]) or both physical and sexual childhood abuse (1.75,[0.94–3.29]) were positively associated with increased odds of asthma, although the associations were not statistically significant in the multivariable analysis. However, the odds of asthma increased with increasing numbers of abuse events (ptrend=0.01). Women who reported ≥3 abuse events had an increased odds of asthma (1.88,[1.06–3.34]). Conclusion Our results do not provide convincing evidence that childhood abuse is associated with asthma among pregnant Peruvian women; however, we were able to demonstrate that an increased number of abuse events are associated with asthma. Further research is required to better understand the effects of abuse on asthma.

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Adverse childhood experiences and risk of type 2 diabetes: A systematic review and meta-analysis

Cited by 199 publications

References 78 publications

Early life adversity influences stress response association with smoking relapse

Early life adversity influences stress response association with smoking relapse

Childhood and Adolescent Adversity and Cardiometabolic Outcomes: A Scientific Statement From the American Heart Association

Childhood abuse and adult-onset asthma among Peruvian women

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