Adverse clinical impact and outcome of inflammation and oxidative stress: Are the antioxidant properties of vitamin C helpful?

Abstract

Inflammation and the oxidative stress are two main notorious driving forces behind the disease progression, deterioration and eventually the death of the individuals concerned. When these two aggravating factors have been effectively addressed, then the disorders affecting people can be under control and relief for the treating clinician. The patients can experience an improvement in health-related quality of life, or better total remission. This review evaluates the relation between oxidative stress in critically ill patients, vitamin C intake as an antioxidant and severity of illness. It also highlights the implications of these two processes in major disease areas, such as cancer, intensive care, sepsis, cardiology, rheumatology, and the damaging outcomes of the imbalance between the production of ROS and antioxidants.
 Citation: Herbert E, Fournier D. Adverse clinical impact and outcome of inflammation and oxidative stress: Are the antioxidant properties of vitamin C helpful? Anaesth. pain intensive care 2022;26(4):710-719.
 DOI: 10.35975/apic.v26i5.1993

The emerging role of oxidative stress in inflammatory bowel disease

“…Vit-C acts as an antioxidant by scavenging free radicals, thereby reducing oxidative damage to cells and tissues ( 202 ). This helps reduce inflammation and oxidative damage, improving IBD patients’ outcomes ( 203 ). Several studies have explored the correlation between Vit-C and OSMs in various inflammatory conditions, highlighting its protective role.…”