Adverse Consequences of Rushing a SARS-CoV-2 Vaccine

Trogen, Brit; Oshinsky, David M.; Caplan, Arthur L.

doi:10.1001/jama.2020.8917

Cited by 82 publications

(87 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The need for speed is understandable, but it comes with risks: specifically, the vaccine candidates that are most capable of rapid production on the required massive scale may not be the most effective, and there are concerns that immune responses to COVID-19 vaccines could enhance infection or exacerbate disease in individuals who become infected despite vaccination. These topics have been raised in multiple perspectives and reviews in recent weeks ( 1 – 12 ). Here, we attempt to address key subjects in greater detail, with an emphasis on quantitative aspects of antibody-based immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).…”

Section: Introductionmentioning

confidence: 99%

COVID-19 Vaccines: “Warp Speed” Needs Mind Melds, Not Warped Minds

Moore

Klasse

2020

J Virol

134

View full text Add to dashboard Cite

In this review, we address issues that relate to the rapid “Warp Speed” development of vaccines to counter the COVID-19 pandemic. We review the antibody response that is triggered by SARS-CoV-2 infection of humans, and how it may inform vaccine research. The isolation and properties of neutralizing monoclonal antibodies from COVID-19 patients provide additional information on what vaccines should try to elicit. The nature and longevity of the antibody response to coronaviruses are relevant to the potency and duration of vaccine-induced immunity. We summarize the immunogenicity of leading vaccine candidates tested to date in animals and humans, and discuss the outcome and interpretation of virus-challenge experiments in animals. By far the most immunogenic vaccine candidates for antibody responses are recombinant proteins, which are not included in the initial wave of “Warp Speed” immunogens. A substantial concern for SARS-CoV-2 vaccines is adverse events, which we review by considering what was seen in studies of SARS-CoV-1 and MERS-CoV vaccines. We conclude by outlining the possible outcomes of the “Warp Speed” vaccine program, which range from the hoped-for rapid success to a catastrophic adverse influence on vaccine uptake generally.

show abstract

Section: Introductionmentioning

confidence: 99%

COVID-19 Vaccines: “Warp Speed” Needs Mind Melds, Not Warped Minds

Moore

Klasse

2020

J Virol

134

View full text Add to dashboard Cite

show abstract

“…Despite the limitations of this study, our findings clearly suggest that governments and regulators should carefully consider the level of evidence required for vaccines to be granted marketing authorization, even if this prolongs clinical trial programs. Fast approvals of vaccines that result in suboptimal immunization of the general public may risk losing the public’s trust in policy decisions [ 23 ].…”

mentioning

confidence: 99%

Willingness to Wait for a Vaccine Against COVID-19: Results of a Preference Survey

Tervonen

Jimenez-Moreno

Krucien³

et al. 2020

Patient

View full text Add to dashboard Cite

“…Rushing development and endorsement of a COVID-19 vaccine before establishing efficacy and safety could endanger not only recipients, but also the uptake of current safe vaccines. 68 However, holding off on vaccine use while completing studies will be stressful for both doctors and families. Pediatricians will need to help design studies in ways that minimize risk and generate useful data as quickly as possible, and then help families to understand the choices that they face.…”

Section: Advocating For the Most Vulnerable Childrenmentioning

confidence: 99%

Seeking Normalcy as the Curve Flattens: Ethical Considerations for Pediatricians Managing Collateral Damage of Coronavirus Disease-2019

Feltman

Moore

Beck

et al. 2020

The Journal of Pediatrics

View full text Add to dashboard Cite

F earful. Uncertain. Overwhelmed. Committed. Hopeful. Pediatricians around the world have cycled through these emotions when considering the health and safety of patients and families during this coronavirus disease 2019 (COVID-19) pandemic. We worry about the direct medical effects of COVID-19. We also worry about the ancillary effects of the lockdowns, stay-at-home orders, closed clinics, schools, and daycare centers, and newly unemployed parents on the well-being of children. We focus on those concerns. We believe that responding to these ancillary effects of COVID-19 will be a bigger challenge for pediatricians than the clinical care of children with COVID-19. These challenges will be with us for the foreseeable future.

show abstract

Adverse Consequences of Rushing a SARS-CoV-2 Vaccine

Abstract: This Viewpoint discusses the importance of carefully evaluating SARS-CoV-2 vaccine candidates for safety and efficacy in the context of political pressure to accelerate the process, widespread vaccine hesitancy and refusal, and distrust of science.

Cited by 82 publications

References 7 publications

COVID-19 Vaccines: “Warp Speed” Needs Mind Melds, Not Warped Minds

COVID-19 Vaccines: “Warp Speed” Needs Mind Melds, Not Warped Minds

Willingness to Wait for a Vaccine Against COVID-19: Results of a Preference Survey

Seeking Normalcy as the Curve Flattens: Ethical Considerations for Pediatricians Managing Collateral Damage of Coronavirus Disease-2019

Contact Info

Product

Resources

About