Adverse drug reaction monitoring with angiotensin converting enzyme inhibitors: A prospective, randomized, open-label, comparative study

Sangole, Nishant V; Dadkar, Vaishali N

doi:10.4103/0253-7613.62408

Cited by 12 publications

(7 citation statements)

References 9 publications

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“…Lisinopril is commonly prescribed for the treatment of hypertension and congestive heart failure 40 , 41 . The side effects of this ACEI are usually mild to moderate in therapeutic doses, the most serious being dry cough, angioedema, and hyperkalemia 41 , 42 . Of these potentially serious side effects, only cough was reported in this study, and it was the seventh most frequently encountered adverse event.…”

Section: Discussionmentioning

confidence: 62%

Low-Dose Lisinopril in Normotensive Men With Idiopathic Oligospermia and Infertility: A 5-Year Randomized, Controlled, Crossover Pilot Study

Mbah

Ndukwu

Ghasi

et al. 2012

Clin Pharmacol Ther

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The outcomes of drug treatment for male infertility remain conjectural, with controversial study results. Our pilot study employed a randomized, placebo-controlled, crossover methodology with intention-to-treat analysis. Thirty-three men with idiopathic oligospermia were randomized to start either daily oral lisinopril 2.5 mg (n = 17) or daily oral placebo (n = 16). Lisinopril was found to cause a normalization of seminal parameters in 53.6% of the participants. Although the mean ejaculate volume was unchanged (P ≥ 0.093), the total sperm cell count and the percentage of motile sperm cells increased (P ≤ 0.03 and P < 0.001, respectively), whereas the percentage of sperm cells with abnormal morphology decreased (P ≤ 0.04). The pregnancy rate was 48.5%, and there was no serious adverse drug event. It is concluded, albeit cautiously, that prolonged treatment with 2.5 mg/day of oral lisinopril may be well tolerated in normotensive men with idiopathic oligospermia, may improve sperm quantity and quality, and may enhance fertility in approximately half of those treated.

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Section: Discussionmentioning

confidence: 62%

Low-Dose Lisinopril in Normotensive Men With Idiopathic Oligospermia and Infertility: A 5-Year Randomized, Controlled, Crossover Pilot Study

Mbah

Ndukwu

Ghasi

et al. 2012

Clin Pharmacol Ther

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“…Several molecular docking and simulation studies were used to predict the efficiency of binding of the ligand with macromolecules [30][31][32][33][34][35] . The ACE inhibitors such as captopril, lisinopril, enalapril, ramipril and perindopril have shown common side effects such as headache, dizziness, cough, low blood pressure, hypotension, nausea, and angioedema [36][37][38] . Since Momordica charantia is considered as a novel plant with diverse applications in food industry as well as in the therapy of many diseases such as diabetes and atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Structural characterization and in-silico analysis of Momordica charantia 7S globulin for stability and ACE inhibition

Kesari

Pratap

Dhankhar

et al. 2020

Sci Rep

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Momordica charantia (Mc) seeds are widely used edible crop with high nutritional quality. The food and pharmaceutical industries use it as a natural anti-oxygenic agent. Herein, a ~52 kDa protein, which is a major part of seed proteome has been purified, biochemically characterized and structure has been determined. MALDI-ESI-MS identified peptide fragments and contig-deduced sequence suggested the protein to be homologous to 7S globulins. The crystal structure shows that protein has a bicupin fold similar to 7S globulins and the electron density for a copper and acetate ligand were observed in the C-terminal barrel domain. In silico study reveals that a tripeptide (VFK) from Mc7S possess a higher binding affinity for angiotensin converting enzyme (ACE) than already reported drug Lisinopril (LPR). The protein is a glycoprotein and highly stable under varying thermal and pH conditions due to its secondary structures. The DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) assay showed the protein to have an anti-oxygenic nature and can aid in scavenging free radical from sample. The protein can assist to enhance the nutritional and functional value of food by acting as a food antioxidant. Further, characterization of Mc7S required which might add in importance of Mc7S as antioxidant, anti-diabetic and anti-hypertensive. Momordica charantia (Mc) commonly known as bitter melon or bitter gourd is a member of Cucurbitaceae family, which grows in tropical and subtropical areas. The plant is known for centuries in Ayurveda for its anti-bacterial, anti-fungal, anti-viral, anti-parasitic, hypoglycemic, anti-fertility, anti-tumorous, and anti-carcinogenic properties 1-5. It is preferred as a medication for a broad range of health applications, including the treatment of dysmenorrhea, eczema, emmenagogue, galactagogue, gout, jaundice, kidney (stone), leprosy, leucorrhea, piles, pneumonia, psoriasis, rheumatism, scabies, T2DM (type 2 diabetes mellitus), obesity, hypertension, bacterial and viral infections, cancer, and even AIDS 1-5. It contains biologically active molecules including proteins, triterpenes, saponins, steroids, flavonoids, alkaloids, and acids 6. Each part of plant i.e. seeds, roots, leaves and especially unripe fruits has its pharmacological properties 4. The juice is used to cure a large number of conditions such as for articular pain relief and chronic fever in jaundice, liver disease, and digestive system diseases because of laxative, diuretic, and anti-helminthic effects. In the case of chronic skin diseases, it is applied locally to treat boils, burns, and rash. Moreover, components of Mc plant i.e. unripe fruit, seeds and aerial parts are largely known for its anti-diabetic properties due to the presence of insulin-mimetic in the seeds 7,8. The aqueous seed extract of Mc also scavenges the free radicals for protection against lipid peroxidation thereby reducing the risk of diabetic complications 9. The strong anti-oxygenic activity may be due to the presence of phenolic compounds and saponins 10. The globula...

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“…58 However, in an Indian ADR monitoring study, phosphoryl group-containing ACEIs (fosinopril) were associated with a higher incidence of cough compared with carboxyl group-containing ACEIs (enalapril, lisinopril, and ramipril). 59 It is reasonable to use ACEIs that induce cough less frequently. In this context, perindopril has been associated with a relatively low incidence of cough and has extensive evidence supporting its cardiovascular benefits and tolerability.…”

Section: Measures Towards Better Management Of Acei-induced Coughmentioning

confidence: 99%

ACEI-induced cough: A review of current evidence and its practical implications for optimal CV risk reduction

Pinto

Jadhav

Singhai

et al. 2020

Indian Heart Journal

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Cough is one of the common adverse effects in patients receiving angiotensin-converting enzyme inhibitors (ACEIs). This review presents the current evidence on incidence and mechanisms of cough associated with ACEIs use, and proposes a practical approach for managing the same for optimal cardiovascular (CV) risk reduction. The incidence of dry cough in patients receiving ACEIs vary among individual ACEIs, and is the lowest with perindopril. Cough is thought to originate from multiple mechanisms, bradykinin theory is the most commonly appealed hypothesis. The strategies for optimal management could be temporarily discontinuation of ACEI upon a reported incidence of cough and reintroduction after its remission. However, studies have reported disappearance of cough despite continuing treatment. Another important approach could be adding calcium channel blockers to ACEIs. Switching to alternative drugs such as angiotensin receptor blockers should be suggested in case intolerable symptoms recur and after exclusion of all other possible causes of cough.

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Adverse drug reaction monitoring with angiotensin converting enzyme inhibitors: A prospective, randomized, open-label, comparative study

Cited by 12 publications

References 9 publications

Low-Dose Lisinopril in Normotensive Men With Idiopathic Oligospermia and Infertility: A 5-Year Randomized, Controlled, Crossover Pilot Study

Low-Dose Lisinopril in Normotensive Men With Idiopathic Oligospermia and Infertility: A 5-Year Randomized, Controlled, Crossover Pilot Study

Structural characterization and in-silico analysis of Momordica charantia 7S globulin for stability and ACE inhibition

ACEI-induced cough: A review of current evidence and its practical implications for optimal CV risk reduction

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