Adverse-drug-reaction related admissions to a hospital in Scotland

Hopf, Yvonne; Watson, Margaret; Williams, David

doi:10.1007/s11096-008-9240-5

Cited by 39 publications

(38 citation statements)

References 19 publications

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“…The studies were conducted between 1992 and 2006. The study periods ranged from two weeks [35] to 21 months [36]. Fourteen studies had a prospective design [23]-[26], [28]-[36], [38], one retrospective [37], and one cross-sectional [27].…”

Section: Resultsmentioning

confidence: 99%

Percentage of Patients with Preventable Adverse Drug Reactions and Preventability of Adverse Drug Reactions – A Meta-Analysis

et al. 2012

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Background Numerous observational studies suggest that preventable adverse drug reactions are a significant burden in healthcare, but no meta-analysis using a standardised definition for adverse drug reactions exists. The aim of the study was to estimate the percentage of patients with preventable adverse drug reactions and the preventability of adverse drug reactions in adult outpatients and inpatients. Methods Studies were identified through searching Cochrane, CINAHL, EMBASE, IPA, Medline, PsycINFO and Web of Science in September 2010, and by hand searching the reference lists of identified papers. Original peer-reviewed research articles in English that defined adverse drug reactions according to WHO’s or similar definition and assessed preventability were included. Disease or treatment specific studies were excluded. Meta-analysis on the percentage of patients with preventable adverse drug reactions and the preventability of adverse drug reactions was conducted. Results Data were analysed from 16 original studies on outpatients with 48797 emergency visits or hospital admissions and from 8 studies involving 24128 inpatients. No studies in primary care were identified. Among adult outpatients, 2.0% (95% confidence interval (CI): 1.2–3.2%) had preventable adverse drug reactions and 52% (95% CI: 42–62%) of adverse drug reactions were preventable. Among inpatients, 1.6% (95% CI: 0.1–51%) had preventable adverse drug reactions and 45% (95% CI: 33–58%) of adverse drug reactions were preventable. Conclusions This meta-analysis corroborates that preventable adverse drug reactions are a significant burden to healthcare among adult outpatients. Among both outpatients and inpatients, approximately half of adverse drug reactions are preventable, demonstrating that further evidence on prevention strategies is required. The percentage of patients with preventable adverse drug reactions among inpatients and in primary care is largely unknown and should be investigated in future research.

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Section: Resultsmentioning

confidence: 99%

Percentage of Patients with Preventable Adverse Drug Reactions and Preventability of Adverse Drug Reactions – A Meta-Analysis

et al. 2012

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“…31 Several other studies have reported similar findings with 60-70% of ADRs being classes as preventable. 4,32,33,34 …”

Section: Preventabilitymentioning

confidence: 99%

Incidence and Factors Associated with Drug Related Hospital Admissions in a South Indian Tertiary Care Hospital

Dammalapati¹,

Challa²,

Challa³

et al. 2018

IJOPP

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Objective:The study aimed to assess the incidence, nature of drug related hospital admissions (DRHAs) and factors associated with DRHAs. Method: A retrospective study was conducted to evaluate the medical records of patients admitted to general medicine department for six months. Drug related hospital admissions were assessed using Helper and Stand Classification. Crude odds ratio (COR) and adjusted odds ratio (AOR) were determined using univariate and multivariate logistic regression analysis. Results: The results of analysis of 1177 medical records reveal that 202 (17.2%) patients were admitted due to 248 DRHAs. Of which, the most common DRHA was non-compliance that accounted for 50.50% (102). Out of 248 drug related hospital admissions, 65.8% (n=163) were definitely preventable, 30.2% (n=75) were possibly preventable and 4.0% (n=10) were definitely not preventable. However, multivariate regression analysis results indicate that hypertension, diabetes mellitus, and polypharmacy at admission are significantly (p< 0.001) associated with DRHA. Conclusion: The factors remarkably associated with drug related hospital admissions are age, diabetes mellitus, hypertension and polypharmacy. The major reasons for drug related hospital admissions are non-compliance and adverse drug reactions. Collaborative efforts among patients, physicians, pharmacists and caregivers might reduce the frequency of drug related hospital admissions.

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“…For example, using medical record review, ADRs and adherence problems [4-6] and ADRs exclusively [7,8] have been shown to contribute to 2.7-8.0% of admissions to UK hospitals [4-8]. These figures are comparable to a recent international systematic review [9] which concluded that 5.8% of admissions are caused by ADRs.…”

Section: Introductionmentioning

confidence: 84%

A descriptive exploratory study of how admissions caused by medication-related harm are documented within inpatients’ medical records

Reynolds

Hickson

Jacklin

et al. 2014

BMC Health Serv Res

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BackgroundAdverse drug reactions, poor patient adherence and errors, here collectively referred to as medication-related harm (MRH), cause around 2.7-8.0% of UK hospital admissions. Communication gaps between successive healthcare providers exist, but little is known about how MRH is recorded in inpatients’ medical records. We describe the presence and quality of MRH documentation for patients admitted to a London teaching hospital due to MRH. Additionally, the international classification of disease 10th revision (ICD-10) codes attributed to confirmed MRH-related admissions were studied to explore appropriateness of their use to identify these patients.MethodsClinical pharmacists working on an admissions ward in a UK hospital identified patients admitted due to suspected MRH. Six different data sources in each patient’s medical record, including the discharge summary, were subsequently examined for MRH-related information. Each data source was examined for statements describing the MRH: symptom and diagnosis, identification of the causative agent, and a statement of the action taken or considered. Statements were categorised as ‘explicit’ if unambiguous or ‘implicit’ if open to interpretation. ICD-10 codes attributed to confirmed MRH cases were recorded.ResultsEighty-four patients were identified over 141 data collection days; 75 met our inclusion criteria. MRH documentation was generally present (855 of 1307 statements were identified; 65%), and usually explicit (705 of 855; 82%). The causative agent had the lowest proportion of explicit statements (139 of 201 statements were explicit; 69%). For two (3%) discharged patients, the causal agent was documented in their paper medical record but not on the discharge summary. Of 64 patients with a confirmed MRH diagnosis at discharge, only six (9%) had a MRH-related ICD-10 code.ConclusionsAvailability of information in the paper medical record needs improving and communication of MRH-related information could be enhanced by using explicit statements and documenting reasons for changing medications. ICD-10 codes underestimate the true occurrence of MRH.

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Adverse-drug-reaction related admissions to a hospital in Scotland

Cited by 39 publications

References 19 publications

Percentage of Patients with Preventable Adverse Drug Reactions and Preventability of Adverse Drug Reactions – A Meta-Analysis

Percentage of Patients with Preventable Adverse Drug Reactions and Preventability of Adverse Drug Reactions – A Meta-Analysis

Incidence and Factors Associated with Drug Related Hospital Admissions in a South Indian Tertiary Care Hospital

A descriptive exploratory study of how admissions caused by medication-related harm are documented within inpatients’ medical records

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