Adverse drug reaction: rosuvastatin as a cause for ischaemic colitis in a 64-year-old woman

Tan, Jackie; Pretorius, Casper F.; Flanagan, Paul Vincent; Pais, Antonio

doi:10.1136/bcr.11.2011.5270

Cited by 7 publications

(3 citation statements)

References 7 publications

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“…Overall, our findings raise the hypothesis that the safety profile of RYR is similar to synthetic statins: myopathies (myalgia, CK and transaminases elevation [48][49][50][51]), cutaneous reactions, gastrointestinal and liver reactions emerged as a potential safety signals of RYR and have been reported as not uncommon adverse reactions associated with statins [52][53][54][55]. These data are also in line with cases collected from WHO-Vigibase and reports received by the ANSES French Agency, where muscle-and liver-related ARs were largely reported with RYR [30].…”

Section: Discussionmentioning

confidence: 60%

Adverse reactions to dietary supplements containing red yeast rice: assessment of cases from the Italian surveillance system

Mazzanti

Moro

Raschi

et al. 2017

Brit J Clinical Pharma

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Section: Discussionmentioning

confidence: 60%

Adverse reactions to dietary supplements containing red yeast rice: assessment of cases from the Italian surveillance system

Mazzanti

Moro

Raschi

et al. 2017

Brit J Clinical Pharma

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“…24 Several adverse effects of statins already were described, including a case of ischemic colitis. 25 In our study, we observed that statins are part of the normal pharmacological profile of patients.…”

Section: Discussionmentioning

confidence: 63%

Untitled

2015

Journal of Coloproctology

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Objective: To identify risk factors, diagnosis and prognosis associated with ischemic colitis, focusing mainly on patients undergoing surgery. Materials and methods:This retrospective study included all patients admitted to the Centro Hospitalar de São João -E. P. E., diagnosed with ischemic colitis during the period from 2012 to 2013. Results:The study included 154 patients; 118 were undergoing medical treatment, with a 12% mortality rate, and 36 were undergoing surgery, with a 61% associated mortality rate.Hypertension was the most common risk factor in both groups. The presence of a large number of cardiovascular risk factors in both groups, such as hypertension and dyslipidemia, was recorded, but we still found no direct relationship with development of ischemic colitis. Comorbidities that affect blood flow, such as the presence of thrombi or aneurysms, do provide a worse prognosis and therefore require a more aggressive treatment. Conclusion:The diagnosis of ischemic colitis is not always immediately established due to a nonspecific presentation. Surgical treatment should be reserved for severe cases with a worse prognosis associated.

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“…Statin medications are widely used for their lipid‐lowering capabilities via inhibition of 5‐hydroxy‐3‐methylglutaryl‐coenzyme A (HMG‐CoA) reductase. Both rosuvastatin and simvastatin have been associated with mild episodes of colon ischaemia . While no exact mechanism for statin‐induced colon ischaemia has been described, it is believed that this class of drugs has no direct vasoactive properties, but patients on statins do have increased lipid levels and likely have peripheral vascular disease.…”

Section: Pharmacologic Agents Moderately Associated With Colon Ischaemiamentioning

confidence: 99%

Review article: the pharmacological causes of colon ischaemia

Vodusek

Feuerstadt

Brandt

2018

Aliment Pharmacol Ther

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Summary Background Colon ischaemia is the most common ischaemic disorder of the gastrointestinal system, can affect any segment of the colon, and may present with a range of symptoms. Diagnosis can be challenging due to symptom overlap with other conditions, varied aetiology, and often rapid and self‐resolving course. Aim To review comprehensively the literature regarding the pharmacological aetiologies of colonic ischaemia to enhance the understanding of the various mechanisms of disease, presentations, distribution, and outcomes. Methods A PubMed search for “colon ischaemia” and “ischaemic colitis” alone as well as in combination with various known pharmacologic causes was performed. Only the highest quality and relevant literature was included in this review. The quality of the literature for each association was rated by the authors and a consensus was made when discrepancies were encountered. Only associations that were deemed “moderate” or “strong” were included. Results The literature considering pharmacologically associated colonic ischaemia is diverse, lacks codification and is characterised by numerous case reports and case series. Constipation‐inducing drugs, digoxin, hormonal therapies, illicit drugs, immunomodulators, laxatives, and NSAIDs were strongly associated with colonic ischaemia. Antimicrobials, appetite suppressants, chemotherapies, decongestants, diuretics, ergot alkaloids, serotonin agents, statins, and vasopressor agents were moderately associated. Conclusions Patients presenting with abdominal pain, diarrhoea, or bloody stool need to be evaluated for the possibility of this condition and treated accordingly. Timely diagnosis is necessary to improve patient outcomes. This review aims to increase awareness among clinicians regarding the presentation of pharmacologically induced colonic ischaemia.

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Adverse drug reaction: rosuvastatin as a cause for ischaemic colitis in a 64-year-old woman

Cited by 7 publications

References 7 publications

Adverse reactions to dietary supplements containing red yeast rice: assessment of cases from the Italian surveillance system

Adverse reactions to dietary supplements containing red yeast rice: assessment of cases from the Italian surveillance system

Untitled

Review article: the pharmacological causes of colon ischaemia

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