Adverse Drug Reactions: A Retrospective Review of Hospitalized Patients at a State Psychiatric Hospital

Iuppa, Courtney A.; Nelson, Leigh Anne; Elliott, Ellie; Sommi, Roger W.

doi:10.1310/hpj4811-931

Cited by 18 publications

(14 citation statements)

References 6 publications

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“…Most of the other studies like Luppa CA et al Kuruvilla A et al and Rothschild J m el al have reported Antipsychotic is most common drug class for ADRs. 7,8,18 From patient"s data, our study was observed that risperidone 19 (46.34%), haloperidol 13 (31.7%), lithium 12 (100%) and imipramine 8 (57.14%) were most frequently suspected drugs in group A while risperidone 10 (45.45%), trifluoperazine 4 (18.18%) and quetiapine 4 (18.18%) were the common causes of ADRs requiring hospitalisation in group B.…”

mentioning

confidence: 77%

“…Targeting high-risk medications that have been identified through analysis could have a significant impact on reducing preventable ADRs. 8 The present study was carried out to study the incidence and the pattern of ADRs taking place in psychiatry units of tertiary care, teaching hospital, Jamnagar over a period of four year. It was thought that this hospital data based monitoring of ADRs can shed light on their extensiveness and pattern of occurrence.…”

Section: Introductionmentioning

confidence: 99%

“…7,16 Luppa CA et al study has shown that most common reported ADR are Acute dystonia, Akathasia, Pseudo parkinsonism. 8 Shah LP et al study shows that most common ADR are Drowsiness, Constipation, Dryness of mouth and Giddiness. 15 Lucca JM et al study shows Weight gain as most common ADR.…”

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confidence: 99%

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Adverse drug reactions: a retrospective review of hospitalized psychiatric patients at tertiary care hospital

Hotha

Jadav

Trivedi

2016

Int J Basic Clin Pharmacol

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confidence: 77%

Section: Introductionmentioning

confidence: 99%

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Adverse drug reactions: a retrospective review of hospitalized psychiatric patients at tertiary care hospital

Hotha

Jadav

Trivedi

2016

Int J Basic Clin Pharmacol

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“…It is worth mentioning a study conducted at a state psychiatric hospital in United States, which underlines the role of clinical pharmacists; where pharmacists also actively review all laboratory results and medication orders for indications that an ADR has occurred and help data entry into an internal online computer database. 17 Yet another study in UAE also fosters the role of clinical pharmacist. 8 Building up of a database with combined efforts of pharmacologists and psychiatrists has been suggested by previous articles.…”

Section: Discussionmentioning

confidence: 99%

Adverse drug reaction profile at psychiatry outpatient department of a tertiary care centre

Gawali

Kesari

Gawand

2017

Int J Basic Clin Pharmacol

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Background: Monitoring adverse drug reactions (ADRs) helps in alerting physicians and developing strategies to prevent and minimize the risk of developing ADRs. Data regarding pattern of ADRs due to psychotropic medications is scanty. Hence, the study was planned to assess ADRs among psychiatry outpatients of a tertiary care hospital in Maharashtra.Methods: A prospective, observational study was conducted in psychiatry outpatient department of a tertiary care centre for 3 months. Cases were enrolled by active and passive surveillance after obtaining informed consent. Demographic details, adverse event details, history of medications were recorded. Pattern of ADRs was studied according to demographic parameters, drug class, organ system affected, causality (WHO - Uppsala Monitoring Centre Scale) and severity (modified Hartwig and Siegel Scale).Results: Out of total 1200 patients screened, 77 qualified the inclusion and exclusion criteria and 92 ADRs were reported; overall incidence rate of 6.41%. Maximum ADRs were reported in the age group of 31- 40 years. 63.63% subjects received more than 2 psychotropic drugs. Among 24 types of ADRs observed, tremor (13.04%) was the commonest, closely followed by somnolence. Antipsychotics (45.65%) were most frequently incriminated and central nervous system (46.73%) the most often affected. Trifluoperazine (11.96%) was the commonest drug, followed by olanzapine and haloperidol (10.53% each). Causality analysis yielded 66 ADRs as “probable” and on severity analysis 80.43% were mild.Conclusions: The study provides an insight into pattern of ADRs in psychiatry outpatients. It is prudent to communicate this to treating physicians as well as counsel patients (and caregivers). Initiatives and concerted efforts involving all stakeholders in healthcare can go a long way in decreasing drug-related morbidity and health costs.

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“…It can be done by the data use of frequency, severity, probability and preventability. After getting all the information of high-risk drugs through analysis may have significant impact on reducing the ADRs 9,10. Hence, an attempt has been made in this article exhibit an updated analysis of ADRs which are caused by antipsychotics drug and how to manage the ADRs in general outlook and what are the future outcomes in the management of adverse drug reaction 11 .…”

Section: Obsessive Compulsive Disorder (Ocd)mentioning

confidence: 99%

Psychotic Disorders, Definition, Sign and Symptoms, Antipsychotic Drugs, Mechanism of Action, Pharmacokinetics & Pharmacodynamics with Side Effects & Adverse Drug Reactions: Updated Systematic Review Article

Bangwal

Bisht

Saklani

et al. 2020

J. Drug Delivery Ther.

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Psychosis is a mental disorder characterized by a disconnection from reality. Psychosis is a group of disorder characterized by thought disorder, abnormal behaviour, defective cognition, delusion and hallucination. Adverse drug reaction is defined as any undesired or unintended effects of drugs treatment. According to the World Health Organization (WHO)- “adverse drug reaction (ADRs) has been defined one which is noxious and unintended, and which occurs at doses normally used in man for prophylaxis, diagnosis, or therapy of disease, or modification of physiological function”. Adverse drug reactions are the most important causes of the mortality and morbidity. Antipsychotics are the most effective drugs which are used in the psychiatry in the maintenance therapy of mania, psychoses and schizophrenia. The antipsychotics drugs are chemically disparate but have the common property of alleviating the symptoms of organic as well as functional psychosis. But they also have a capacity to cause a wide range of potential adverse drug reactions that can lead to non-compliance that can impair quality of life, may cause the extra pyramidal symptoms which can lead to discontinuation of therapy and in extreme cases it may be fatal. Knowledge of assessment of ADRs due to different antipsychotics is necessary. It helps to choose to safe treatment and reduce the risk of occurrence of ADRs by the clinicians. ADR are often poorly identified and reported in day to day medical practice. As we collect more and more information about ADRs, we need an active surveillance system regarding identification and reporting of ADRs with antipsychotic drugs. On many review articles are read & ward round participation experiences we find that antipsychotic drugs can have shown a various kind of ADRs. Psychiatrist and clinical pharmacist are need to be made aware of these potentially fatal adverse effects associated with antipsychotic drugs via conduction of patients counseling regarding (drugs, disease, doses & side effects), quality-based seminars, published medical literature, conferences, learning programs and health care camps. Keywords: Antipsychotic Drugs, WHO, Adverse Drug Reactions, Pharmacovigilance, Psychiatrist.

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Adverse Drug Reactions: A Retrospective Review of Hospitalized Patients at a State Psychiatric Hospital

Abstract: ADRs were most commonly associated with mood stabilizers and antipsychotics, and pADRs were common. There is an opportunity to provide education to medical staff on therapeutic drug monitoring and drug-drug interactions for these classes, particularly lithium.

Cited by 18 publications

References 6 publications

Adverse drug reactions: a retrospective review of hospitalized psychiatric patients at tertiary care hospital

Adverse drug reactions: a retrospective review of hospitalized psychiatric patients at tertiary care hospital

Adverse drug reaction profile at psychiatry outpatient department of a tertiary care centre

Psychotic Disorders, Definition, Sign and Symptoms, Antipsychotic Drugs, Mechanism of Action, Pharmacokinetics & Pharmacodynamics with Side Effects & Adverse Drug Reactions: Updated Systematic Review Article

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