Adverse drug reactions as a reason for admission to an internal medicine ward in Argentina

Álvarez, Paulino; Bril, Fernando; Castro, Verónica; Meiville, Itati; Gonzalez, Claudio; Gómez‐Centurión, Ignacio; Parejas, Griselda; Riera, Cristina Soler; Saubidet, Cristián López; Girolamo, Guillermo Di; Keller, Guillermo Alberto

doi:10.3233/jrs-130596

Cited by 22 publications

(15 citation statements)

References 28 publications

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“…Moreover, patients who died with ADRs had a higher CCI than surviving patients without ADRs (3.9 ± 2.9 vs 1.6 ± 1.8, 95% CI: 1.4-3.2) (Table 1). ADRs in this study is comparable to previously described figures of 85.7%-92% 59,60. However, studies conducted in South Africa reported that only 45% 10 and 53% 12 of ADRs were preventable.…”

supporting

confidence: 89%

Mortality from adverse drug reaction-related hospitalizations in south-west Ethiopia: A cross-sectional study

et al. 2018

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Fatal ADRs were common in patients presenting to hospital. The drugs implicated were mostly antitubercular and antiretroviral therapies, reflecting the high burden of HIV and tuberculosis in the study population. ADR-related deaths were significantly associated with poor nutritional status. The majority of ADR-related deaths were preventable, highlighting the need to develop a multidisciplinary approach to closely monitor patients who are prescribed antitubercular and antiretroviral therapies, particularly in patients with hepatic disease, a history of ADRs, who are malnourished and who are exposed to multiple medications.

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confidence: 89%

Mortality from adverse drug reaction-related hospitalizations in south-west Ethiopia: A cross-sectional study

et al. 2018

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“…We observe that for younger ages, RI [0,29] is much lower than the model's predicted RI [0,29] (Fig. 2-b); the same is true for the number of patients affected ( Fig.…”

Section: Age Risksupporting

confidence: 51%

“…Omeprazole is used to treat acid reflux and other gastroesophageal problems, while Clonazepam is a benzodiazepine anti-epileptic. This prevalent dispensation requires particular attention to dosage since "Omeprazole may increase the pharmacological effect and serum levels of certain benzodiazepines via hepatic enzyme inhibition" [28,29]. Similarly, (Acetylsalicylic Acid (ASA), Glyburide)…”

Section: Drugs Involved In Interactionsmentioning

confidence: 99%

City-wide electronic health records reveal gender and age biases in administration of known drug–drug interactions

et al. 2019

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The occurrence of drug–drug-interactions (DDI) from multiple drug dispensations is a serious problem, both for individuals and health-care systems, since patients with complications due to DDI are likely to reenter the system at a costlier level. We present a large-scale longitudinal study (18 months) of the DDI phenomenon at the primary- and secondary-care level using electronic health records (EHR) from the city of Blumenau in Southern Brazil (pop. ≈340,000). We found that 181 distinct drug pairs known to interact were dispensed concomitantly to 12% of the patients in the city’s public health-care system. Further, 4% of the patients were dispensed drug pairs that are likely to result in major adverse drug reactions (ADR)—with costs estimated to be much larger than previously reported in smaller studies. The large-scale analysis reveals that women have a 60% increased risk of DDI as compared to men; the increase becomes 90% when considering only DDI known to lead to major ADR. Furthermore, DDI risk increases substantially with age; patients aged 70–79 years have a 34% risk of DDI when they are dispensed two or more drugs concomitantly. Interestingly, a statistical null model demonstrates that age- and female-specific risks from increased polypharmacy fail by far to explain the observed DDI risks in those populations, suggesting unknown social or biological causes. We also provide a network visualization of drugs and demographic factors that characterize the DDI phenomenon and demonstrate that accurate DDI prediction can be included in health care and public-health management, to reduce DDI-related ADR and costs.

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confidence: 99%

“…Frequencies of fatal ADRs have ranged widely, from 0.09% to 0.65%, in hospitalized patients [3][4][5][6][7][8][9]. However, the incidence of fatal ADRs can largely depend on the type of hospital or ward [9][10][11]. Drugs most frequently involved in fatal ADRs have been cytotoxic agents, antithrombotics and nonsteroidal anti-inflammatory drugs (NSAIDs) [3,9,[12][13][14][15][16][17].…”

mentioning

confidence: 99%

Drug‐Related Inadvertent Deaths in a University Hospital – A Declining Trend

Lapatto‐Reiniluoto

Patinen

Niemi

et al. 2015

Basic Clin Pharma Tox

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Abstract:We studied the incidence of fatal adverse drug reactions (ADRs) in a tertiary hospital to find out which drugs were involved. The secondary objective was to compare the data from the same hospital published 12 years earlier. All 1708 death cases in the Helsinki University Central Hospital during the year 2012 were retrospectively evaluated. All suspected drug-related deaths, excluding suicides, were scrutinized by an expert panel using the WHO ADR probability classification. Of all cases, 52 (3.0%) were classified as certainly or probably drug related and 24 (1.4%) as possibly drug related. Together, these corresponded to 0.02% of all hospital admissions. The most commonly involved drugs in certain or probable cases were cytostatics (18 cases, 1.1% of all cases) and antithrombotics (17, 1.0%). Twelve years earlier, these caused 27 (1.8%) and 22 (1.5%) cases, respectively. Non-steroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids caused less (2 and 0 cases) fatal ADRs than earlier (12 and 4 cases, p = 0.048 and p = 0.005, respectively). Most of the ADRs leading to death were present already in admission and affected seriously ill or elderly patients. Hospital-born fatal ADRs occurred in 0.003% of patients. In conclusion, cytostatics and antithrombotics are still the leading causes of fatal ADRs, but NSAIDs and glucocorticoids seem to cause fatal ADRs less often than previously. The incidence of fatal ADRs in 2012 was 3.0% of all deaths, suggesting a decline compared to the 2000 value (5.0%). Improved awareness, prevention and treatment of ADRs and safer medicines may explain these declining trends.

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Adverse drug reactions as a reason for admission to an internal medicine ward in Argentina

Cited by 22 publications

References 28 publications

Mortality from adverse drug reaction-related hospitalizations in south-west Ethiopia: A cross-sectional study

Mortality from adverse drug reaction-related hospitalizations in south-west Ethiopia: A cross-sectional study

City-wide electronic health records reveal gender and age biases in administration of known drug–drug interactions

Drug‐Related Inadvertent Deaths in a University Hospital – A Declining Trend

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