Adverse drug reactions in a psychiatric department of tertiary care teaching hospital in India: Analysis of spontaneously reported cases

Patel, Tejas; Bhabhor, Prakash; Desai, Nimisha; Shah, Saurabh; Patel, Pooja; Vatsala, Ela; Panigrahi, Sanjibani

doi:10.1016/j.ajp.2015.07.003

Cited by 18 publications

(21 citation statements)

References 19 publications

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“…15 In contrast to our findings, a study conducted by Patel et al, reported an incidence rate of 0.69% in psychiatry outpatients. 16 The females showed high incidence of ADRs than males which is in accordance with the previous studies. 8,17 This increased risk may be due to gender-related differences in pharmacokinetic, immunological, hormonal factors and differences in the use of medications.…”

Section: Discussionsupporting

confidence: 91%

Monitoring of adverse drug reactions in psychiatry outpatient department of a tertiary care hospital in Central India

Mahakalkar

Tiple

Mohod

et al. 2020

Int J Basic Clin Pharmacol

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Background: Adverse drug reactions (ADRs) are prevalent in patients taking psychotropic medications and can occur even at the normal doses used in the management of acute and maintenance phases of psychiatric disorders. Pharmacovigilance have cardinal role in alerting the healthcare providers from the possible ADRs and thus protecting the patients who are using psychotropic medications. To Monitor and estimate the incidence and nature of ADRs in psychiatry OPD of tertiary care hospital in central India and assess the causality, preventability and severity of documented ADRs.Methods: A prospective observational study was conducted in psychiatry out-patient department (OPD). Patients diagnosed with any psychiatric disorder and receiving psychotropic medications was included in the study. The recorded data were filled in the ADR form obtained from pharmacovigilance program of India (PvPI). Causality assessment was done using Naranjo scale and severity was assessed using Hartwig scale and preventability assessment using modified Schumock and Thornton’s scale.Results: The incidence rate of ADR was found to be 15.8%. A total of 61 ADRs were documented. Weight gain 14 (18.1%) followed by nausea 11 (14.2%) was the most commonly reported ADR. Atypical antipsychotics were the most common class of psychotropic drugs implicated in ADRs. Clonazepam 21 (27.2%) followed by amitriptyline 20 (25.9%) were associated with a maximum number of ADRs. Majority of the suspected ADRs were probable in nature (40.9%) followed by possible type (31%).Conclusions: Study revealed a moderate incidence of ADRs in patients attending the psychiatry OPD. Majority of the ADRs reported during the study were mild in nature and definitely preventable type.

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Section: Discussionsupporting

confidence: 91%

Monitoring of adverse drug reactions in psychiatry outpatient department of a tertiary care hospital in Central India

Mahakalkar

Tiple

Mohod

et al. 2020

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

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“…17 Patel TK et al, analysed spontaneous ADRs reported at Department of psychiatric at Gujarat found schizophrenia was leading indication followed by depression. 18 An observational study conducted in Psychiatric OPD by Sengupta G et al, in Kolkata found bipolar affective disorder (27%), schizophrenia (24%) followed by depression (22%) were common indication for drug treatment. 3 Most common system organ class involved in this study was neurological disorder (32.82%), gastrointestinal disorder (22.79%) followed by psychiatric disorder (17.02%).…”

Section: Discussionmentioning

confidence: 99%

“…In this study, male (57.3%) were affected more with ADRs than female (42.7%) with male:female ratio 1. 3,[16][17][18] This finding may be because of high prevalence of psychiatric illness in this age group. 19 Most common indication for psychiatric drugs in this study was depression (26%), followed by schizophrenia (15.2%), bipolar mood disorder (12.9%) and epilepsy (12.9%).…”

Section: Discussionmentioning

confidence: 99%

Pattern of adverse drug reactions into psychiatric patients

Barvaliya

Panchal

Desai

et al. 2019

Int J Basic Clin Pharmacol

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Background: To analyse adverse drug reactions (ADRs) reported in patients prescribed psychiatric medications at tertiary care hospital.Methods: ADRs reported in psychiatric patients between January 2011 to June 2017 were analyzed for demographic details, causal drugs, system organ classification, causality assessment (WHO-UMC criteria and Naranjo’s scale), preventability (Modified Schumock and Thorton’s criteria) and severity (Hartwing scale).Results: A total 4368 ADRs were reported during study period, out of which 658 (15.06%) were in psychiatric patients. The mean age of patients was 38±13.34 years and men (57.3%) were most commonly affected than women (42.7%). The most common causal drug groups were antidepressants (29.48%) followed by antipsychotics (23.12%) which include drug fluoxetine (33.9%) and olanzapine (34.3%) respectively. The most common system involved were central nervous system (32.8%) followed by gastrointestinal system (22.8%). Most of ADRs (42.7%) were observed after one month of therapy and showed possible (77%) causal relation with drug therapy. Majority of ADRs (77.4%) were not preventable and mild in nature (83.3%).Conclusions: ADRs are commonly seen in psychiatric patients. Hence, their monitoring and assessment in these patients who require multidrug and long-term therapy may help improve patient management.

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“…For example, in an article on Mexican patients with schizophrenia, the authors demonstrated the usefulness of a pharmacological interaction database for the simultaneous use of benzodiazepines and antidepressants [ 27 ]. In another study conducted on men and women over a period of 3 years in a psychiatric department, the authors used a pharmacological interaction database, i.e., Medscape, to illustrate the incidence of possible adverse reactions associated with drug interactions [ 28 ]. However, as previously mentioned, there are very few studies conducted by only a few authors working in the field of psychiatry.…”

Section: Discussionmentioning

confidence: 99%

Increasing the Effectiveness of Pharmacotherapy in Psychiatry by Using a Pharmacological Interaction Database

Ordak

Nasierowski

Muszyńska

et al. 2021

JCM

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Recent studies have shown that the knowledge of pharmacological interaction databases in global psychiatry is negligible. The frequency of hospitalizations in the case of patients taking new psychoactive substances along with other drugs continues to increase, very often resulting in the need for polypharmacotherapy. The aim of our research was to make members of the worldwide psychiatric community aware of the need to use a pharmacological interaction database in their daily work. The study involved 2146 psychiatrists from around the world. Participants were primarily contacted through the LinkedIn Recruiter website. The surveyed psychiatrists answered 5 questions concerning case reports of patients taking new psychoactive substances along with other drugs. The questions were answered twice, i.e., before and after using the Medscape drug interaction database. The mean percentage of correct answers given by the group of psychiatrists who were studied separately in six individual continents turned out to be statistically significantly higher after using the pharmacological interaction database (p < 0.001). This also applies to providing correct answers separately, i.e., to each of the five questions asked concerning individual case reports (p < 0.001). Before using the drug interaction database, only 14.1% of psychiatrists stated that they knew and used this type of database (p < 0.001). In the second stage of the study, a statistically significant majority of subjects stated that they were interested in using the pharmacological interaction database from that moment on (p < 0.001) and expressed the opinion that it could be effective in everyday work (p < 0.001). Using a pharmacological interaction database in psychiatry can contribute to the effectiveness of pharmacotherapy.

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Adverse drug reactions in a psychiatric department of tertiary care teaching hospital in India: Analysis of spontaneously reported cases

Cited by 18 publications

References 19 publications

Monitoring of adverse drug reactions in psychiatry outpatient department of a tertiary care hospital in Central India

Monitoring of adverse drug reactions in psychiatry outpatient department of a tertiary care hospital in Central India

Pattern of adverse drug reactions into psychiatric patients

Increasing the Effectiveness of Pharmacotherapy in Psychiatry by Using a Pharmacological Interaction Database

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