Adverse Drug Reactions in an Elderly Hospitalised Population

Passarelli, Maria Cristina Guerra; Jacob‐Filho, Wilson; Figueras, Albert

doi:10.2165/00002512-200522090-00005

Cited by 304 publications

(245 citation statements)

References 47 publications

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“…However, there is controversy regarding whether the use of PIM is a risk factor for hospital admission [10,12,13,16] . In this study, one out of four (15/59) patients who reported taking PIM had been admitted to hospital for ADR.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the identified PIM, 55.0% of them were related to ADR, of which 73% (8 / 11) are frequently prescribed for older people, according to the literature: digoxin [8][9][10]14,16,29] , amitriptyline [9,10,13,14,16,29] , amiodarone [8][9][10]14,16,29] , diazepam [10][11][12][13][14] , methyldopa [9,10,12,17,29] , cimetidine [9][10][11]16,29] , fluoxetine [9,10,14,16,29] and short-acting nifedipine [8][9][10]14,16] . Data suggest that prescribers do not know the drugs considered PIM for older people, since there are safer alternatives for most inadequate medications identified in the present study, such as selective serotonin reuptake inhibitors or serotonin-specific reuptake inhibitor (e.g.…”

Section: Albert Et Al (2010)mentioning

confidence: 99%

“…Potentially inappropriate medication (PIM) are those medications or classes of medications that should be avoided in patients aged ≥ 65 years, since they have no clear evidence-based indication, are not cost-effective [5] , pose unnecessarily high risk for older persons [6] , once the risks of using overcome the benefits [7] , and safer alternatives are available [6,8] . The exposure of older people to PIM is associated with the increased use of health care services [9] , ADR [4,10] and higher medical costs [11] . However, PIM prescriptions are common among these patients [12] , since studies have shown that 24.5% to 66.0% [8,[11][12][13][14][15][16] of older people take these drugs.…”

Section: Introductionmentioning

confidence: 99%

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Safety Assessment of Potentially Inappropriate Medications Use in Older People and the Factors Associated with Hospital Admission

et al. 2011

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-Purpose: Potentially Inappropriate Medications (PIM) use in elderly people may be responsible for the development of Adverse Drug Reaction (ADR) which, when severe, leads to hospital admissions. Objectives: to estimate the prevalence of elderly who had used PIM before being admitted to hospital and to identify the risk factors and the hospitalizations related to ADR arising from PIM. Methods: A descriptive and cross-sectional study was performed in the internal medicine ward of a teaching hospital (Brazil), in 2008. With the aid of a validated form, patients aged ≥ 60 years, with length of hospital stay ≥ 24 hours, were interviewed about drugs taken prior to the hospital admission and the complaints/reasons for hospitalization. Results: 19.1% (59/308) of older patients had taken PIM before hospital admission and in 4.9%; there were a causal relation between the PIM taken and the complaint reported. PIM responsible for admissions were: amiodarone, amitriptyline, cimetidine, clonidine, diazepam, digoxin, estrogen, fluoxetine, lorazepam, short-acting nifedipine and propranolol. 47.0% of the clinical manifestations of PIM-related ADR were: dizziness, fatigue, digoxin toxicity and erythema. Only polypharmacy was detected as a risk factor for the occurrence of ADR of PIM (p = 0.02). Conclusion: PIM use in elderly people is not a risk factor for ADR-related hospital admission. Probably, severe ADR, which lead to hospitalizations of older people, can be explained by idiosyncratic response or the predisposition of these patients to develop adverse drug events, whether or not drugs are classed as PIM.

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Section: Discussionmentioning

confidence: 99%

Section: Albert Et Al (2010)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Safety Assessment of Potentially Inappropriate Medications Use in Older People and the Factors Associated with Hospital Admission

et al. 2011

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“…The frequency of such effects may reach 19%, and two thirds of them can be avoided. 2 In Brazil, drug adverse effects among hospitalized patients have been studied by using a longitudinal approach, 3,4 reviewing medical files retrospectively 1 or using the hospital database of the Sistema Único de Saúde (SUS -National Health System). 5 The objective of the present study was to analyze the results from a strategy of monitoring drug adverse effects that was applied in a public hospital.…”

Section: Introductionmentioning

confidence: 99%

Efeitos adversos a medicamentos em hospital público: estudo piloto

et al. 2009

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The results from implementing a strategy for monitoring adverse effects from drugs in a public hospital in the municipality of Rio de Janeiro, Southeastern Brazil, in 2007, were analyzed. Based on retrospective analysis of 32 medical files, adverse effects were found in 16%. To identify these effects, 38 tracking criteria were needed. Among these, the main ones were the use of antiemetics, abrupt cessation of medication and oversedation. Despite the difficulties, especially in relation to access to information and the record quality, application of these tracking criteria seems to be viable. To improve the implementation of the method, it is suggested that the data collection should be computerized and risk adjustment indicators should be sought.

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“…Este riesgo aumenta con la fragilidad del paciente y con la polifarmacoterapia (3). Las reacciones adversas a medicamentos constituyen una causa importante de morbimortalidad de los pacientes, un reto para el profesional de la salud y un problema de salud pública para la ciudad y el país (4,5).…”

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Caracterización de reacciones adversas a medicamentos en adultos mayores de 44 años en Bogotá, D.C., enero - diciembre de 2012

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2014

biomedica

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Introducción. El envejecimiento de la población en Colombia es una realidad. Los ancianos consumen más medicamentos que los jóvenes, por lo que están más expuestos a las reacciones adversas que estos puedan provocar. Objetivo. Caracterizar las sospechas de reacciones adversas a medicamentos que se presentaron en los adultos mayores de 44 años en Bogotá, en el año 2012. Materiales y métodos. Se llevó a cabo un estudio de farmacovigilancia que incluyó 470 reportes de reacciones adversas a medicamentos y problemas relacionados con su uso en adultos mayores de 44 años registrados en la base de datos del Programa Distrital de Farmacovigilancia de Bogotá. Resultados. Se evaluaron 470 reportes de reacciones adversas y problemas relacionados con el uso de medicamentos en adultos mayores de 44 años. De estos, 432 reportes (91,9 %) correspondieron a la categoría de sospecha de reacción adversa a medicamentos y 28 (6 %), a la de problemas relacionados con su uso. La tasa de incidencia de eventos adversos notificados en Bogotá fue de 22,5 por 100.000 adultos mayores, la cual aumentó de forma directamente proporcional a la edad de los pacientes. El grupo farmacológico más reportado fue el de los antibacterianos, con 94 notificaciones. El sistema orgánico más comprometido fue la piel y sus anexos, con 21,2 % de los casos. En cuanto a la evaluación de la gravedad, el 69,5 % de las reacciones adversas fueron moderadas, y con relación a la causalidad, la mayoría, es decir, 45,8 % de los reportes, se catalogaron como posibles. Conclusiones. La caracterización de las reacciones adversas a medicamentos en adultos mayores de Bogotá es similar a la reportada en la literatura científica para este grupo de población.Palabras clave: efectos colaterales y reacciones adversas relacionados con medicamentos, anciano; anciano de 80 o más años, antiinflamatorios no esteroideos, antibacterianos, farmacovigilancia. doi: http://dx.doi.org/10.7705/biomedica.v35i1.2194Characterization of adverse drug reactions in adults over 44 years of age in Bogota, JanuaryDecember, 2012Introduction: In Colombia, aging of the population is a reality and elders consume more drugs than the young do. Consequently, they are more exposed to adverse drug reactions. Objective: To characterize suspected adverse drug reactions in adults over 44 years of age in Bogota in 2012. Materials and methods:We conducted a pharmacological surveillance study that included 470 reports of adverse drug events and associated problems with the use of drugs in adults over 44 years old included in the database of Bogotá's pharmacosurveillance program. Results: We evaluated 470 reports of adverse drug events and associated problems with the use of drugs in adults over 44 years of age. From these, 432 reports (91.9%) were classified as suspected adverse drug reactions and 28 (6%), as associated problems with the use of drugs. The incidence rate for adverse drug events reported in Bogotá was 22.5 for every 100,000 elders, which increased in direct proportion to patients' age. The most frequen...

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Adverse Drug Reactions in an Elderly Hospitalised Population

Cited by 304 publications

References 47 publications

Safety Assessment of Potentially Inappropriate Medications Use in Older People and the Factors Associated with Hospital Admission

Safety Assessment of Potentially Inappropriate Medications Use in Older People and the Factors Associated with Hospital Admission

Efeitos adversos a medicamentos em hospital público: estudo piloto

Caracterización de reacciones adversas a medicamentos en adultos mayores de 44 años en Bogotá, D.C., enero - diciembre de 2012

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