Adverse Drug Reactions in Norway: A Systematic Review

Vaismoradi, Mojtaba; Logan, Patricia; Jordan, Sue; Sletvold, Hege

doi:10.3390/pharmacy7030102

Cited by 10 publications

(9 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Adverse drug reactions (ADRs) pose a substantial and growing burden on healthcare systems and are the leading cause of hospital readmissions and associated co-morbidities, many of which can be prevented. 1,2 Cutaneous adverse drug reactions (CADRs) are the most frequent adverse events resulting from medication use. 3 CADRs encompass all adverse events related to drug eruption, regardless of aetiology.…”

Section: What Is K Nown and Objec Tivementioning

confidence: 99%

General characteristics, economic burden, causative drugs and medical errors associated with medical damage litigation involving severe cutaneous adverse drug reactions in China

Zheng

Jiang

et al. 2020

J Clin Pharm Ther

View full text Add to dashboard Cite

What is known and objective To investigate the general characteristics, economic burden, causative drugs and medical errors associated with litigation involving severe cutaneous adverse drug reactions (SCADRs) in China, with the aims of improving rational medication use and reducing the extent of damage from SCADRs. Methods This study analysed 150 lawsuit judgements involving SCADRs from 2005 to 2019, collected from China Judgments Online. Results and discussion In total, 50% of lawsuits stemmed from SCADRs occurring in general hospitals. The average time elapsed from the date of occurrence of the SCADRs to the end of litigation procedures was 1055 days. Of the patients involved, 51% were female and more than two thirds (69%) were under 60 years old. The most common outcome of SCADRs was death (39%), followed by disabilities (30%). The average responsibility of the medical provider was 48 ± 29%. The average amount of compensation was $43 424. Of the cases studied, 51% of SCADRs were Stevens‐Johnson syndrome or toxic epidermal necrolysis, which together accounted for 75% of cases with known clinical subtype. The overall average economic burden of SCADRs was $99 178, of which indirect costs made up the largest proportion (more than 60%). The most common causative drug groups were antimicrobial drugs (49%), Chinese patent medicine and Chinese herbal medicine (17%), and antipyretic analgesics (16%). Finally, 61% of medical errors were found to stem from violation of duty of care, 20% from violation of informed consent and 18% from violations related to the medical record writing and management system. What is new and conclusion Severe cutaneous adverse drug reactions not only severely affect patient survival and quality of life, but also impose a heavy economic burden in terms of health care and societal costs. Medical providers should be better educated on strategies to reduce risk to patients and establish mechanisms of risk sharing and management.

show abstract

Section: What Is K Nown and Objec Tivementioning

confidence: 99%

General characteristics, economic burden, causative drugs and medical errors associated with medical damage litigation involving severe cutaneous adverse drug reactions in China

Zheng

Jiang

et al. 2020

J Clin Pharm Ther

View full text Add to dashboard Cite

show abstract

“…Other causes for ADR risks might be elderly patients' contact with multiple prescribers, lack of time among GPs, clinical guidelines' for a single-disease focus, and knowledge limitations [8]. A recent systematic review in Norway also found ADRs to be fairly common, and the authors reported a lack of necessary feedback and quality improvement systems [9]. Several lists of potentially inappropriate drugs (PIDs) in the elderly and harmful drug combinations have been established [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Improving drug prescription in general practice using a novel quality improvement model

Øyane

Finckenhagen

Ruths

et al. 2021

Scandinavian Journal of Primary Health Care

View full text Add to dashboard Cite

Introduction: Quality improvement (QI) clusters have been established in many countries to improve healthcare using the Breakthrough Series' collaboration model. We investigated the effect of a novel QI approach based on this model of performed medication reviews and drug prescription in a Norwegian municipality. Methods: All 27 General Practitioners (GPs) in a mid-size Norwegian municipality were invited to join the intervention, consisting of three peer group meetings during a period of 7-8 months. Participants learned practical QI skills by planning and following up QI projects within drug prescription practice. Evaluation forms were used to assess participants' self-rated improvement, reported medication review reimbursement codes (MRRCs) were used as a process measure, and defined daily doses (DDDs) of potentially inappropriate drugs (PIDs) dispensed to patients aged 65 years or older were used as outcome measures. Results: Of the invited GPs, 25 completed the intervention. Of these, 76% self-reported improved QI skills and 67% reported improved drug prescription practices. Statistical process control revealed a non-random increase in the number of MRRCs lasting at least 7 months after intervention end. Compared with national average data, we found a significant reduction in dispensed DDDs in the intervention municipality for benzodiazepine derivates, benzodiazepinerelated drugs, drugs for urinary frequency and incontinence and non-steroid anti-inflammatory and antirheumatic medications. Conclusion:Intervention increased the frequency of medication reviews, resulting in fewer potentially inappropriate prescriptions. Moreover, there was self-reported improvement in QI skills in general, which may affect other practice areas as well. Intervention required relatively little absence from clinical practice compared with more traditional QI interventions and could, therefore, be easier to implement. KEY POINTThe current study investigated to what extent a novel model based on the Breakthrough Series' collaborative model affects GP improvement skills in general practice and changes their drug prescription. KEY FINDINGSMost participants reported better improvement skills and improved prescription practice. The number of dispensed potentially inappropriate drugs decreased significantly in the intervention municipality compared with the national average. The model seemed to lead to sustained changes after the end of the intervention.

show abstract

“…LTV acts as an inhibitor of the HCMV DNA terminase complex by interacting with the pUL56 subunit of such complex and preventing the cleavage of concatemeric DNA into monomeric genome length DNA, which ultimately inhibits DNA packaging into the virion. LVT displays good efficacy against different clinical isolates of HCMV, including GCV-resistant strains, and is ineffective against all other herpesviruses [217].…”

Section: Treatmentmentioning

confidence: 99%

Where do we Stand after Decades of Studying Human Cytomegalovirus?

et al. 2020

View full text Add to dashboard Cite

Human cytomegalovirus (HCMV), a linear double-stranded DNA betaherpesvirus belonging to the family of Herpesviridae, is characterized by widespread seroprevalence, ranging between 56% and 94%, strictly dependent on the socioeconomic background of the country being considered. Typically, HCMV causes asymptomatic infection in the immunocompetent population, while in immunocompromised individuals or when transmitted vertically from the mother to the fetus it leads to systemic disease with severe complications and high mortality rate. Following primary infection, HCMV establishes a state of latency primarily in myeloid cells, from which it can be reactivated by various inflammatory stimuli. Several studies have shown that HCMV, despite being a DNA virus, is highly prone to genetic variability that strongly influences its replication and dissemination rates as well as cellular tropism. In this scenario, the few currently available drugs for the treatment of HCMV infections are characterized by high toxicity, poor oral bioavailability, and emerging resistance. Here, we review past and current literature that has greatly advanced our understanding of the biology and genetics of HCMV, stressing the urgent need for innovative and safe anti-HCMV therapies and effective vaccines to treat and prevent HCMV infections, particularly in vulnerable populations.

show abstract

Adverse Drug Reactions in Norway: A Systematic Review

Cited by 10 publications

References 40 publications

General characteristics, economic burden, causative drugs and medical errors associated with medical damage litigation involving severe cutaneous adverse drug reactions in China

General characteristics, economic burden, causative drugs and medical errors associated with medical damage litigation involving severe cutaneous adverse drug reactions in China

Improving drug prescription in general practice using a novel quality improvement model

Where do we Stand after Decades of Studying Human Cytomegalovirus?

Contact Info

Product

Resources

About