Adverse drug reactions of local anesthetics used in dentistry

Матвеев, А. В.; Крашенинников, А. Е.; Yagudina, R.; Егорова, Е. А.; Konyaeva, E. I.

doi:10.17116/stomat20209906182

Cited by 5 publications

(3 citation statements)

References 10 publications

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“…Otro estudio realizado entre 2010 y 2018 reveló que tras el uso de anestésicos locales la necesidad de hospitalización o prolongación de la hospitalización fue necesaria en 7 casos (5,8%), y la incapacidad temporal de los pacientes se reveló en 5 casos (4,1%). De particular interés son 2 casos (1,6%) de desarrollo de muerte como resultado de la sospecha de shock anafiláctico (1 caso) y trastornos del sistema nervioso central (convulsiones, desarrollo de insuficiencia respiratoria) (22). pág.…”

Section: Resultsunclassified

Reacciones Adversas más Frecuentes en los Anestésicos Locales

Buendia Gomez,

Díaz Díaz,

Benavides Raillo

et al. 2024

Ciencia Latina

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Los anestésicos locales son ampliamente usados en la práctica clínica en diferentes escenarios, de tal manera que el impacto de los fármacos anestésicos localizados actualmente corresponde a dos tipos: amidas y ésteres. El efecto de dichos fármacos se produce a través de su interacción con canales de sodio dependiente del voltaje, lo que previene la generación y propagación de potenciales de acción en los axones. Por consiguiente se ha realizado una búsqueda bibliográfica de artículos científicos en español e inglés, de diferentes casos donde se evidencia las reacciones adversas que estos anestésicos pueden llegar a ocasionar. Por lo tanto es fundamental saber que al momento de elegir un anestésico local, se debe administrar adecuadamente el medicamento, teniendo en cuenta aspectos como dosis y velocidad de administración, los cuales son factores esenciales para reducir el riesgo de eventos adversos.

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Section: Resultsunclassified

Reacciones Adversas más Frecuentes en los Anestésicos Locales

Buendia Gomez,

Díaz Díaz,

Benavides Raillo

et al. 2024

Ciencia Latina

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“…French Pharmacovigilance Database System analysis revealed a twentyfold growth of reports on anaphylactic reactions involving local anesthetics from 1985 to 2020 year, and lidocaine was reported to be the most common cause (81.49%) [40]. Leading role of lidocaine in severe HSRs and in anaphylaxis development in dental practice was stated in the work by Matveev AV et al (2020) [41]. Anesthetics (first, lidocaine, secondbupivacaine) were reported among top eight pharmacotherapeutic groups involved in anaphylaxis based on results of Vietnamese Pharmacovigilance Database analysis [21].…”

Section: Discussionmentioning

confidence: 99%

Drug-induced Anaphylaxis: National Database Analysis

Butranova,

Zyryanov,

Gorbacheva

et al. 2023

Preprint

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(1) Background: National health system databases represent one of the most obvious sources of information about epidemiology of adverse drug reactions including drug-induced allergy and anaphylaxis. (2) Methods: Retrospective analysis of data from national database of pharmacovigilance in the Russian Federation (analyzed period 02.04.2019 - 21.06.2023) was performed. The prevalence of anaphylactic reactions (ARs) was determined, the structure of drugs involved was estimated together with patients’ characteristics. (3) Results: ARs were reported in 8.3% of drug-induced allergic reactions (2304/27,727), mean age of patients was 48.2 ± 15.8 years, 53.2% were females. Main causative groups of drugs were antibiotics, ABs (44.62%), local anesthetics, (19.97%), and cyclooxygenase (COX)-inhibitors (10.07%). Fatal ARs was reported in 9.5% (218/2304), mean age 48.0 ± 16.7 years, 56.2% females. Pediatric population accounted for 5.8% (133/2304), mean age 11.8± 4.5 years, 51.9% females. Elderly population accounted for 2.8% (65/2304), mean age 73.0±5.3 years, 43.5% (27/65) females. ABs were the leading causative groups of ARs in the elderly (40%), children (42.86%), and among fatal cases (50%). (4) Conclusions: ARs accounted for 8.3% of all drug-induced allergic reactions, and ABs were the most common causative agents. Females predominated in all groups except elderly patients.

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“…A French Pharmacovigilance Database System analysis revealed a twentyfold growth in the number of reports on anaphylactic reactions involving local anesthetics from 1985 to 2020, and lidocaine was reported to be the most common cause (81.49%) [ 40 ]. The leading role of lidocaine in severe HSRs and anaphylaxis development in dental practice was stated in the work by Matveev et al (2020) [ 41 ]. Anesthetics (first, lidocaine, second, bupivacaine) were reported to be among the top eight pharmacotherapeutic groups involved in anaphylaxis based on the results of a Vietnamese Pharmacovigilance Database analysis [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Drug-Induced Anaphylaxis: National Database Analysis

Butranova,

Zyryanov,

Gorbacheva

et al. 2024

Pharmaceuticals

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(1) Background: National health system databases represent an important source of information about the epidemiology of adverse drug reactions including drug-induced allergy and anaphylaxis. Analysis of such databases may enhance the knowledge of healthcare professionals regarding the problem of drug-induced anaphylaxis. (2) Methods: A retrospective descriptive analysis was carried out of spontaneous reports (SRs) with data on drug-induced anaphylaxis (SRsAs) extracted from the Russian National Pharmacovigilance database (analyzed period 2 April 2019–21 June 2023). The percentage of SRsAs among SRs of drug-induced allergy (SRsDIAs) was calculated, as well as of pediatric, elderly, and fatal SrsAs. Drugs involved in anaphylaxis were assessed among total SRsAs, pediatric, and elderly SRsAs, and among fatal SRsAs. Demographic parameters of patients were assessed. (3) Results: SRsAs were reported in 8.3% of SRsDIAs (2304/27,727), the mean age of patients was 48.2 ± 15.8 years, and females accounted for 53.2% of cases. The main causative groups of drugs were antibacterials (ABs) for systemic use (44.6%), local anesthetics (20.0%), and cyclooxygenase (COX) inhibitors (10.1%). Fatal SRsAs were reported in 9.5% (218/2304) of cases, the mean age of patients was 48.0 ± 16.7 years, and females accounted for 56.4% of cases. Pediatric SRsAs accounted for 3.9% of pediatric SRsDIAs and 5.8% of all SRsAs, with a mean age of 11.8 ± 4.5 years, and females acccounted for 51.9% of cases. Elderly SRsAs accounted for 2% of elderly SRsDIAs and 2.8% of all SRsAs, and the mean age was 73.0 ± 5.3 years, and females accounted for 43.5% of cases. ABs caused 40% of SRsAs in the elderly, 42.9% in children, and 50% of fatal SRsAs. (4) Conclusions: Our study revealed a relatively high proportion of anaphylaxis among SRs of drug-induced allergy. ABs were the most prevalent causative agents, especially in fatal SRsAs.

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Adverse drug reactions of local anesthetics used in dentistry

Cited by 5 publications

References 10 publications

Reacciones Adversas más Frecuentes en los Anestésicos Locales

Reacciones Adversas más Frecuentes en los Anestésicos Locales

Drug-induced Anaphylaxis: National Database Analysis

Drug-Induced Anaphylaxis: National Database Analysis

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