Adverse drug reactions to anti-diabetic drugs are commonest in patients whose treatment do not adhere to diabetes management clinical guidelines: cross-sectional study in a tertiary care service in sub-Saharan Africa

Elangwe, Agnes; Katte, Jean-Claude; Tchapmi, Donald; Figueras, Albert; Mbanya, Jean Claude

doi:10.1007/s00228-020-02949-2

Cited by 10 publications

(12 citation statements)

References 12 publications

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“…21,39 Even though, in another study almost 83% of patients who used metformin alone have mild to moderate eruption without severe adverse drug reactions. 40…”

Section: Oral Medicationsmentioning

confidence: 99%

Potential skin problems of diabetes mellitus patients: a review

2022

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Diabetes mellitus (DM) is one of the common metabolic disorders, and a major part of chronic diseases, the prevalence of which tends to increase due to multifactor. Blood vessels, kidneys, lungs, and skin are among the organs that are affected. The first problem that arises, or commonly exists among one-third of diabetics, are problems with their skin, although skin lesions may develop along with the progress of the disease, or can occur during the later phase of DM. The prevalence and symptoms of skin problems in type 1 DM (T1DM) and type 2 DM (T2DM) are often unclear, and at the beginning of the course of the diseases they often go undiagnosed. Several theories regarding the pathophysiology of DM can be used as a logical reference for the early identification and diagnosis of skin problems, aimed at preventing the worsened condition. The use of skin autofluorescence (SAF) and AGEs reader in several cases of skin problems, can also be an important marker as an adjunct to predict the possibility and progressiveness of DM. Skin problems linked to patients with DM can be categorized as strongly related to diabetes, non-specific and related to DM, skin infection in DM, and skin problems due to diabetic medication. With the current COVID-19 pandemic, there are additional demands for more critical investigation of skin problems in patients with DM. The skin problems that occur in DM may need to be examined from the early stage and it is necessary to inhibit the progression of skin problems, as well as to consider the need for multidisciplinary DM therapy.

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“…21,39 Even though, in another study almost 83% of patients who used metformin alone have mild to moderate eruption without severe adverse drug reactions. 40…”

Section: Oral Medicationsmentioning

confidence: 99%

Potential skin problems of diabetes mellitus patients: a review

2022

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“…Modern and herbal medicines help regulate blood glucose levels by increasing insulin production or receptor sensitivity, leading to enhanced glucose uptake or glycogen hydrolysis inhibition . Modern drugs have adverse effects, making people with diabetes prone to other diseases . Hence, consumers opt for more natural remedies to mitigate ailments and demand a more cost-effective approach with a higher potency and fewer side effects.…”

Section: Introductionmentioning

confidence: 99%

“…4 Modern drugs have adverse effects, making people with diabetes prone to other diseases. 5 Hence, consumers opt for more natural remedies to mitigate ailments and demand a more cost-effective approach with a higher potency and fewer side effects. Many varieties of plants have been used for their medicinal properties to alleviate disease symptoms for ages.…”

Section: ■ Introductionmentioning

confidence: 99%

Formulation of Whole Wheat Bitter Gourd-Supplemented Cookies for Improving Blood Glycemic Levels: Insights of Inhibition Assays and Antioxidant Activities

Khan,

Ahmed,

Maghaydah

et al. 2024

ACS Food Sci. Technol.

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Mechanical lifestyles have increased the incidence of diabetes over the past decade, making it a significant, rapidly growing, and degenerative disease all around the globe. The study aimed to evaluate the efficacy of the hypoglycemic effect of bitter gourd (BG)-supplemented whole wheat cookies in managing blood glucose levels. 1−3% (w/w) BG powder was supplemented into cookies. The cookies showed a significant positive relation (p < 0.05) between supplementation of BG, radical scavenging potential, ferric-reducing ability, presence of phenols, and inhibition of α-amylase and α-glucosidase enzymes. The one-week cookies' storage study showed insignificant differences in the alteration of antioxidant and antidiabetic activity of BG cookies, showing its stability at room temperature. Incorporating BG into cookies at different inclusion levels showed highly significant results (p < 0.05) for all treatments of α-amylase and α-glucosidase inhibition. 1% (w/w) BG cookies showed promising sensory evaluation results and better overall acceptability.

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“…A few studies from low-and-middle-income countries have reported ADRs in the diabetic population in the hospital setting [19][20][21][22][23]. However, those studies were focused mainly on ADRs due to anti-diabetic medications or reported ADRs as part of drug-therapy problems (DTPs) in diabetes and were methodologically weak with most being observational studies.…”

Section: Introductionmentioning

confidence: 99%

Diabetes mellitus increases risk of adverse drug reactions and death in hospitalised older people: the SENATOR trial

Chinmayee,

Subbarayan,

Myint

et al. 2023

Preprint

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Purpose: Adverse drug reactions (ADRs) are a major cause of morbidity and mortality, especially in older people. Older people with diabetes mellitus may be at especially high risk of ADRs but this risk has not been well studied. This study aimed to compare severity and type of ADRs in hospitalised, multimorbid older people with and without diabetes and secondly to assess the impact of ADRs on mortality, rehospitalisation and length of stay. Methods: Participants in the SENATOR (Software Engine for the Assessment and optimization of drug and non-drug Therapy in Older peRsons) trial were assessed for 12 common and ‘other’ prevalent and incident adverse drug reactions using a blinded end-point adjudication process. Descriptive analyses, logistic regression and mediation analyses were undertaken. Results: Of 1537 people in the SENATOR trial, 540 (35.1%) had diabetes mellitus (mean age 77.4 ± 7.3 years, 58.5% male). In the total population, 773 prevalent and 828 incident ADRs were reported. Both prevalent and incident symptomatic hypoglycaemia and incident acute kidney injury (AKI) were significantly more common in people with diabetes (p<0.05). Patients with diabetes had higher all-cause mortality at 12 weeks than those without (9.1% vs 6.3%, p=0.04). Mediation analysis revealed that mortality was significantly higher (OR = 1.43, Sobel test p=0.048) in people with diabetes and ADRs causing AKI. Conclusions: Older multimorbid people with diabetes presenting to hospital with acute illness have significantly more ADRs than those without, and a significantly higher mortality that is mediated by medication-associated AKI and poorer renal function.

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Adverse drug reactions to anti-diabetic drugs are commonest in patients whose treatment do not adhere to diabetes management clinical guidelines: cross-sectional study in a tertiary care service in sub-Saharan Africa

Cited by 10 publications

References 12 publications

Potential skin problems of diabetes mellitus patients: a review

Potential skin problems of diabetes mellitus patients: a review

Formulation of Whole Wheat Bitter Gourd-Supplemented Cookies for Improving Blood Glycemic Levels: Insights of Inhibition Assays and Antioxidant Activities

Diabetes mellitus increases risk of adverse drug reactions and death in hospitalised older people: the SENATOR trial

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