Adverse Effect in Human Beings Associated with Excess Dietary Protein Intake

Gautam, Bhanu Pratap Singh; Gondwal, Manjul; Kishore, N.

doi:10.1007/978-81-322-2491-4_9

Cited by 3 publications

(5 citation statements)

References 40 publications

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“…Excessive protein intake also could lead to overweight, which would increase the burden on the body organs and further delay the healing of pressure ulcers. Our results are consistent with the study by Gautam et al ( 19 ). The healing degree of rats with the most protein intake (25%) was lower than that of rats with 20% protein intake, although the difference was not significant.…”

Section: Discussionsupporting

confidence: 94%

“…Our study further demonstrated that protein is beneficial to pressure ulcer healing, albeit not in excess. Gautam et al ( 19 ) reported that high protein consumption diets may induce disorders and increase the burden on metabolic organs, causing a negative impact on body functions. Excessive protein intake also could lead to overweight, which would increase the burden on the body organs and further delay the healing of pressure ulcers.…”

Section: Discussionmentioning

confidence: 99%

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Pressure ulcer healing promoted by adequate protein intake in rats

et al. 2018

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The effect of protein intake on rat pressure ulcer healing was evaluated. One hundred rats were numbered according to body weight and then they were randomly divided into 4 groups (n=25) using the random number table. After rat models of stage II pressure ulcer were established, they were fed with feed containing different protein levels (10, 15, 20 and 25%). Healing time, pressure ulcer area, body weight, albumin (ALB) and hemoglobin (Hb) levels among groups were compared. Hematoxylin and eosin (H&E) staining was also performed to observe pressure ulcer tissue structure. In the healing process of pressure ulcer, rats with 20% protein intake had the shortest healing time and the smallest pressure ulcer area. Body weight, ALB and Hb levels were much closer to the normal level. H&E staining result also suggested that the pressure ulcer healing degree of rats with 20% protein intake was much better than the others. Adequate protein intake is therefore conducive to pressure ulcer healing, while excessive or insufficient protein intake has negative impact on healing.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Pressure ulcer healing promoted by adequate protein intake in rats

et al. 2018

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“…There is only limited information available concerning the possible adverse effects of long-term protein supplement utilization; this highlights the need for better regulation and guidance for protein supplement availability and dosage, respectively, especially for specific risk populations, such as people at risk of kidney failure [55]. Furthermore, liver and bone metabolism may be profusely challenged because of excessive protein intake [56], and future research is needed to allow clear science-based recommendations for specific population groups.…”

Section: Protein and Amino Acid Supplements Targeted For Better Atmentioning

confidence: 99%

Protein Supplements and Their Relation with Nutrition, Microbiota Composition and Health: Is More Protein Always Better for Sportspeople?

et al. 2019

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Sports nutrition products are developed and targeted mainly for athletes to improve their nutrient intake, performance, and muscle growth. The fastest growing consumer groups for these products are recreational sportspeople and lifestyle users. Although athletes may have elevated physiological protein requirements and they may benefit from dietary supplements, the evidence regarding the role of dietary protein and supplements in the nutrition of recreational sportspeople and sedentary populations is somewhat complex and contradictory. In high-protein diets, more undigested protein-derived constituents end up in the large intestine compared to moderate or low-protein diets, and hence, more bacterial amino acid metabolism takes place in the colon, having both positive and negative systemic and metabolic effects on the host. The aim of the present review is to summarize the impact of the high-protein products and diets on nutrition and health, in sportspeople and in sedentary consumers. We are opening the debate about the current protein intake recommendations, with an emphasis on evidence-based effects on intestinal microbiota and personalized guidelines regarding protein and amino acid supplementation in sportspeople and lifestyle consumers.

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“…Protein overconsumption (i.e., protein that is nutritionally unnecessary) in western countries has been widely reported [ 11 , 12 , 13 ] and is far above the Population Reference Intake (PRI) [ 14 ]. There is a clear rationale to decrease the daily intake of protein since a substantial body of evidence associates the overconsumption of protein with adverse effects on human health, such as disorders of bone and calcium homeostasis, renal and liver dysfunction, increased cancer risk, hyperalbuminemia and precipitated progression of coronary artery disease [ 15 , 16 , 17 , 18 , 19 , 20 ]. Refs.…”

Section: Introductionmentioning

confidence: 99%

“…[ 21 , 22 ], therefore, suggest a ‘reversed’ diet transition by ‘using less’ (e.g., leaving the meat out of the dish) or ‘doing things differently’ by a diet reformulation strategy, with reduced protein content in food products appears to be the most effective approach. However, plans to convince free and affluent societies to eat healthy but not innately desired food have been largely unsuccessful in the past [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. Since the beginning of nutritional science, it has been hypothesised that the nutrients ingested through our diet are not entirely absorbed in the body, and only part of them are available.…”

Section: Introductionmentioning

confidence: 99%

Resistant Protein: Forms and Functions

Zannini

Sahin

Arendt

2022

Foods

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Several global health risks are related to our dietary lifestyle. As a consequence of the overconsumption of ultra-processed and highly digestible protein (150–200% of the recommended value), excess dietary proteins reach the colon, are hydrolysed to peptides and amino acids by bacterial proteases and fermented to various potentially toxic end products. A diet reformulation strategy with reduced protein content in food products appears to be the most effective approach. A potential approach to this challenge is to reduce food digestibility by introducing resistant protein into the diet that could positively influence human health and gut microbiome functionality. Resistant protein is a dietary constituent not hydrolysed by digestive enzymes or absorbed in the human small intestine. The chemical conformation and the amino acid composition strictly influence its structural stability and resistance to in vivo proteolysis and denaturation. Responding to the important gap in our knowledge regarding the digestibility performance of alternative proteins, we hypothesise that resistant proteins can beneficially alter food functionality via their role in improving metabolic properties and health benefits in human nutrition, similar to fibres and resistant starches. A multidisciplinary investigation of resistant protein will generate tremendous scientific impact for other interlinked societal, economic, technological and health and wellbeing aspects of human life.

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Adverse Effect in Human Beings Associated with Excess Dietary Protein Intake

Cited by 3 publications

References 40 publications

Pressure ulcer healing promoted by adequate protein intake in rats

Pressure ulcer healing promoted by adequate protein intake in rats

Protein Supplements and Their Relation with Nutrition, Microbiota Composition and Health: Is More Protein Always Better for Sportspeople?

Resistant Protein: Forms and Functions

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