Adverse effects induced by diclofenac, ibuprofen, and paracetamol toxicity on immunological and biochemical parameters in Swiss albino mice

Gomaa, Soha

doi:10.1186/s41936-018-0025-7

Cited by 37 publications

(31 citation statements)

References 45 publications

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“…Our findings reported that DS induced alteration in liver function biomarkers as it significantly elevated ALT, AST activities; significantly reduced serum total protein and albumin levels; and these findings were in accordance with the previous study reported by 28 , 29 and 30 ; who showed that liver injury resulted from NSAIDs including diclofenac sodium may be proposed to their acidic moiety or reactive metabolites that bind to host proteins inducing cellular injury; and agreed with 31 who denoted that diclofenac form significant alterations in serum protein contents by interference in protein metabolism. Furthermore, our results were in parallel with 32 who reported that increased levels of serum glutamic oxaloacetic transaminase (GOT) and serum glutamic pyruvic transaminase (GPT) indicate a marker of liver injury and damage liver cell.…”

Section: Discussionsupporting

confidence: 93%

Eucalyptus Globulus protects against diclofenac sodium induced hepatorenal and testicular toxicity in male rats

Mousa

Elweza

Elbaz

et al. 2020

Journal of Traditional and Complementary Medicine

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The current study was conducted to investigate the protective properties of Eucalyptus globulus leaves methanolic extract (EGLME) against diclofenac sodium (DS) induced hepatorenal and testicular toxicity in male rats. A total of 40 rats were equally divided into 4 groups, Control, Diclofenac sodium (DS), EGLME and DS + EGLME groups, respectively. DS and EGLME were administered orally at dose rate 2.5 and 100 mg/kg BW, 4 times/week for 8 weeks, respectively. Administration of DS distorted hepatorenal functions manifested by alteration of serum levels of ALT, AST, total protein and albumin, creatinine and urea with changes of histological architectures. DS caused reproductive toxicity represented by minimized sperm count, individual sperm motility and viability; depleted concentration of reduced glutathione (GSH) in testicular tissue; and decreased testosterone level with alteration in testicular histological features. In contrast, co-treatment of DS intoxicated rats with EGLME protected rats against the adverse effects of DS revealing enhancing properties of EGLME on rats’ liver, kidney and testes. In conclusion, we demonstrated that EGLME had a potent protecting property against DS induced hepatic, renal and testicular toxicity in male rats, with special concern to testicular tissue via modulation of GSH as an oxidant marker. Taxonomy (classification by EVISE): Diclofenac sodium toxicity (hepatorenal and testicular toxicity), co-treatment with natural herbal extract, blood biochemical assays, tissue anti-oxidants assay, histopathology and reproductive indices analyses.

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Section: Discussionsupporting

confidence: 93%

Eucalyptus Globulus protects against diclofenac sodium induced hepatorenal and testicular toxicity in male rats

Mousa

Elweza

Elbaz

et al. 2020

Journal of Traditional and Complementary Medicine

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“…The high level of both Ur and Cr in the animals of this study was consistent with a group of studies that were carried out on albino mice [3,24] and on rats [10,22]. In contrast, the study results of [25] showed that IB caused a slight but insignificant decrease in the level of Ur and Cr in the blood of mice, contradicting the results of the current study. This difference may be attributed to the dose, method of administration, and duration of dose, and the difference in the experimental animals.…”

Section: Discussionsupporting

confidence: 86%

Physiological Study of Olive Oil Effect on Ibuprofen-Induced Liver and Kidney Dysfunction in Local Male Rabbits

Yaseen

Abdulmanea

Salem

2020

Electron. J. Univ. Aden Basic Appl. Sci.

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Ibuprofen (IB), is one of the common nonsteroidal anti-inflammatory drugs (NSAIDs), it is mostly used for the management of pain, fever, and inflammations. In addition to its beneficial effects; IB has also been reported to be associated with some adverse effects. Thus, the present study was aimed to investigate the possible beneficial effects of olive oil (OO) against the IB -induced dysfunction of liver and kidney parameters in male rabbits. This study was conducted on 18 local male rabbits weighing between (900 - 1000 g) for 30 days, rabbits were divided into three equal groups; control group (C), ibuprofen group (IB), and ibuprofen +olive oil group (IB + OO), each group included six rats. At the end of the experiment, blood samples were collected for biochemical assessment of the liver and kidney functions. The results showed that IB caused a significant increase (P˂ 0.001) in alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), urea (Ur), creatinine (Cr), and uric acid (UA). A significant decrease in the total protein (TP) and albumin (AL) (P˂ 0.001) and (P˂ 0.05) respectively showed in the IB group compared to the control group. Treatment rabbits with OO showed significant improvement in renal and liver functions; the activity enzymes of ALT, AST, and ALP significantly decreased, and the levels of TP and AL significantly increased. The current results were in agreement with other previous studies which informed that the IB has adverse effects on the functional capacities of the liver and the kidney. Further studies are needed to evaluate this ameliorative effect of OO on other medicines and pollutants.

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“…Hematological studies ( Gomaa, 2018 ) of the blood parameters were done using a Horiba Medical analyzer (model MICROS 60, USA).…”

Section: Methodsmentioning

confidence: 99%

C-Phycocyanin-a novel protein from Spirulina platensis- In vivo toxicity, antioxidant and immunomodulatory studies

Grover

Bhatnagar

Kumari

et al. 2021

Saudi Journal of Biological Sciences

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A pigment-protein highly dominant in Spirulina is known as C-Phycocyanin. Earlier, in vitro studies has shown that C-phycocyanin is having many biological activities like antioxidant and anti-inflammatory activities, antiplatelet, hepatoprotective, and cholesterol-lowering properties. Interestingly, there are scanty in vivo experimental findings on the immunomodulatory and antioxidant effects of C-phycocyanin. This work is aimed at in vivo evaluation of the effects of C-phycocyanin on immunomodulation and antioxidant potential in Balb/c mice. Our results of in vivo toxicity, immunomodulatory and antioxidant effects of C-Phycocyanin suggests that C-phycocyanin is very safe for consumption and having substantial antioxidant potential and also possess immunomodulatory activities in Balb/c mice in a dosage dependent manner. C-phycocyanin doesn’t cause acute and subacute toxicity in the animal model (male, Balb/c mice) studied. We have reported that C-phycocyanin exhibited in vivo immunomodulation performance in this animal model.

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Adverse effects induced by diclofenac, ibuprofen, and paracetamol toxicity on immunological and biochemical parameters in Swiss albino mice

Cited by 37 publications

References 45 publications

Eucalyptus Globulus protects against diclofenac sodium induced hepatorenal and testicular toxicity in male rats

Eucalyptus Globulus protects against diclofenac sodium induced hepatorenal and testicular toxicity in male rats

Physiological Study of Olive Oil Effect on Ibuprofen-Induced Liver and Kidney Dysfunction in Local Male Rabbits

C-Phycocyanin-a novel protein from Spirulina platensis- In vivo toxicity, antioxidant and immunomodulatory studies

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