Adverse Effects of Antipsychotic Agents

Simpson, George M.; Pi, Edmond H.; Sramek, John J.

doi:10.2165/00003495-198121020-00004

Cited by 73 publications

(15 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The serum concentrations in both patients were far beyond the pro posed therapeutic range in children (1-4 ng/ml) [ Haloperidol, a butyrophenone with central dopamine receptor block ing activity, is one of the high-potency drugs more likely to produce extrapyramidal signs, but causes less disturbance in consciousness, epileptogenic and peripheral effects [8] as seen in the 2 cases described herein. The haloperidol-induced extrapyramidal syndrome is believed to be characteristi cally a dose-related phenomenon, although one case report described acute dystonia as an idiosyncratic reaction to haloperidol [9].…”

Section: Commentmentioning

confidence: 86%

Toxic Haloperidol Reactions with Observation of Serum Haloperidol Concentration in Two Children

Tsujimoto¹,

Tsujimoto²,

Ishizaki³

et al. 1982

Dev Pharmacol Ther

View full text Add to dashboard Cite

In 2 children who accidentally received haloperidol (0.26 mg/kg in one and 0.10 mg/kg in another) from a prescription error, haloperidol concentrations in serum in both cases and in cerebrospinal fluid in one case were measured with the radioimmunoassay method during the development of the toxic drug reactions. The serum haloperidol concentrations in both cases were far beyond the proposed therapeutic range in children. Our cases are generally compatible with previous findings of others and indicate that the intensity and/or incidence of toxic reactions of haloperidol may be related to plasma concentrations.

show abstract

Section: Commentmentioning

confidence: 86%

Toxic Haloperidol Reactions with Observation of Serum Haloperidol Concentration in Two Children

Tsujimoto¹,

Tsujimoto²,

Ishizaki³

et al. 1982

Dev Pharmacol Ther

View full text Add to dashboard Cite

show abstract

“…Sedation was the most common ADE and it was most commonly associated with the use of antipsychotics and sedatives. Sedatives are known to be associated with sedation in the elderly [48] and antipsychotics, which are commonly used to treat behavioral symptoms in dementia, also often lead to ADEs including oversedation [7,45,[49][50][51] .…”

Section: Discussionmentioning

confidence: 99%

Adverse Drug Events in Cognitively Impaired Elderly Patients

Ganjavi¹,

Herrmann²,

Rochon³

et al. 2007

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

Background/Aims: Adverse drug events (ADEs) are a frequent problem encountered in the elderly. The aim of this study was to elucidate the factors that influence ADEs in an elderly population with cognitive impairment. Methods: 242 patients were recruited from dementia clinics and assessed after 6 months for ADEs. The use of natural health products (NHPs) was also documented. Results: Backward logistic regression found that higher age (OR = 1.06; 95% CI 1.01–1.12), and greater cognitive impairment (OR = 0.94; 95% CI 0.90–0.98) were associated with an increased risk of developing an ADE while the use of NHPs (OR = 0.32; 95% CI 0.13–0.79) was associated with a decreased risk (χ² = 27.6, p < 0.001). Conclusion: Risk of ADEs increased with greater age and cognitive impairment but decreased with the use of NHPs.

show abstract

“…They range from anaphylaxis, erythema multiforme, photosensitivity, licheniform, psoriasiform, pitiryasiform, Steven Johnson syndrome, skin pigmentation, a lupus-like fixed drug eruption, seborrhoea and pseudolymphomatous eruption. [10][11] The drugs implicated are phenothiazines (especially chlorpromazine), thiothixene, fluphenazine, fluspirilene, loxapine and levomepromazine. [2][3][4][5] We hereby report the following case of Erythema multiforme due to amisulpride in a patient with residual schizophrenia.…”

Section: Introductionmentioning

confidence: 99%