Adverse effects of bisphenol A to spermiogenesis in mice and rats

Adverse effects of bisphenol A on the testicular parenchyma of zebrafish revealed using histomorphological methods

“…This differs from what was observed in rodents when, at seven days after exposure to 20-200 µg/kg, the sustentacular cells were not affected except for the ectoplasmia specialisation around the spermatids (Toyama et al 2004). In contrast, in our study, the tumefaction of these cells was not observed below the concentration of 10 µg/l.…”

“…Under the electron microscope, abnormal acrosomal caps and invagination and/or vacuole formation in the nuclei were observed. A severe deformation of the acrosome and nucleus in older spermatids (Toyama et al 2004), much more accentuated lesions, therefore, than those observed by us at the concentration of 10 µg/l, could indicate a differential sensitivity to BPA exposure between rodents and zebrafish. The OECD has identified the latter as one of the alternatives to mammals for use as a model organism for the evaluation of neuroendocrine disruption (OECD 2006).…”

Effects of exposure to bisphenol A during pregnancy and lactation on the testicular morphology and caspase-3 protein expression of ICR pups

“…Studies have shown that daily sperm production is reduced significantly and the structure of sperm cells undergoes significant changes in adult mice fed BPA (15). Testicular function is two-fold; producing sperm in the process of spermatogenesis, and involvement in the synthesis of steroid hormones, which consist mainly of testosterone and a small amount of estrogen (16).…”

Antiandrogenic and Estrogenic Compounds: Effect on Development and Function of Male Reproductive System

“…It was demonstrated that rodents exposed to BPA during fetal and/or neonatal life had decreased weights of the epididymis and seminal vesicles, but increased weights of the prostate and preputial glands, decreased epithelial height in the efferent ducts and decreased levels of testicular testosterone (Akingbemi et al, 2004;Fisher et al, 1999;vom Saal et al, 1998). Alterations in ectoplasmic specialization between the Sertoli cell and spermatids, abnormalities in the acrosomal granule and nucleus of spermatids, reduced percentage of motile sperm, and increased incidence of sperm malformations were also observed (Aikawa et al, 2004;Toyama et al, 2004). Similar changes in the seminiferous epithelium and reduced fertility were found in adult males treated with BPA (Toyama et al, 2004).…”

“…Alterations in ectoplasmic specialization between the Sertoli cell and spermatids, abnormalities in the acrosomal granule and nucleus of spermatids, reduced percentage of motile sperm, and increased incidence of sperm malformations were also observed (Aikawa et al, 2004;Toyama et al, 2004). Similar changes in the seminiferous epithelium and reduced fertility were found in adult males treated with BPA (Toyama et al, 2004). BPA was found to act directly on Leydig cell steroidogenesis, affecting the expression of cytochrome cytochrome P450 17 -hydroxylase/C 17-20 lyase (P450c17) and aromatase enzymes and interfering with LH receptor-ligand binding (Akingbemi et al, 2004;Svechnikov et al, 2010).…”