Adverse effects of bisphenol A on Sertoli cell blood-testis barrier in rare minnow Gobiocypris rarus

Tao, Shiyu; Wang, Lihong; Zhu, Zeliang; Yan, Long; Wu, Lian; Yuan, Cong; Guo, Zhang; Wang, Zaizhao

doi:10.1016/j.ecoenv.2019.01.007

Cited by 43 publications

(24 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Alternatively, the pollutants could have crossed the blood-testis barrier (BTB) and affected the actively dividing spermatogonia resulting in damaged DNA. The plausibility of this concept is low in conjunction with the fact that (1) the arterial blood flow to the testis is rather low (about 9.6 mL/min out of a cardiac output of~4.7 L/min) [49,50] and (2) the BTB is one of the tightest blood-tissue barriers known to exist in mammalian tissues, even more difficult to cross than the blood brain barrier [51][52][53]. In fact, one of the main role of the BTB is to prevent small molecules, and hence also harmful contaminants, from passing through the paracellular space [54].…”

Section: Discussionmentioning

confidence: 99%

“…In fact, one of the main role of the BTB is to prevent small molecules, and hence also harmful contaminants, from passing through the paracellular space [54]. On the other hand, despite being one of the strongest blood-tissue barriers, recent studies reported adverse effects of xenobiotics, such as bisphenol A and monobutyl phthalate, on Sertoli cell BTB [51,52]. To clarify this aspect, further investigation should be performed, particularly on spermatozoa, that unfortunately were not available to this study.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Relationship Between Widespread Pollution Exposure and Oxidized Products of Nucleic Acids in Seminal Plasma and Urine in Males Attending a Fertility Center

Poli

Andreoli

Moscato

et al. 2020

IJERPH

View full text Add to dashboard Cite

Background: In recent decades, there has been an increase in male infertility, and in many cases, the etiology remains unclear. Several studies relate male hypo-fertility to xenobiotic exposure, even if no data exist about multiple exposure at the environmental level. Methods: The study involved 86 males with diagnosis of idiopathic male infertility (IMI), and 46 controls with no alteration in sperm characteristics. Seminal plasma (SP) and urine samples were analyzed by liquid chromatography tandem mass spectrometry (LC-MS/MS) to quantify biomarkers of exposure (the main metabolites of benzene, toluene, 1,3-butadiene, 3-monochloropropanediol, styrene, and naphthol) and effect (oxidized products of nucleic acids).Results: Biomarker concentrations were similar in subjects with IMI and controls even if a stronger correlation between biomarkers of exposure and effects were observed in SP. Data show that, both in SP and urine, most metabolites were inter-correlated, indicating a simultaneous co-exposure to the selected substances at the environmental level. Principal component analysis showed in SP the clustering of mercapturic acids indicating a preferential metabolic pathway with Glutathione (GSH) depletion and, consequently, an increase of oxidative stress. This result was also confirmed by multivariable analysis through the development of explanatory models for oxidized products of nucleic acids. Conclusions: This study highlights how oxidative stress on the male reproductive tract can be associated with a different representation of metabolic pathways making the reproductive tract itself a target organ for different environmental pollutants. Our results demonstrate that SP is a suitable matrix to assess the exposure and evaluate the effects of reproductive toxicants in environmental/occupational medicine. The statistical approach proposed in this work represents a model appropriate to study the relationship between multiple exposure and effect, applicable even to a wider variety of chemicals.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Relationship Between Widespread Pollution Exposure and Oxidized Products of Nucleic Acids in Seminal Plasma and Urine in Males Attending a Fertility Center

Poli

Andreoli

Moscato

et al. 2020

IJERPH

View full text Add to dashboard Cite

show abstract

“…In colorectal cancer cells, mechanistic studies revealed conflicting results. Small interfering RNA (siRNA)-mediated silencing of TINCR in HCT116 and HCT8 cells suppressed cell proliferation, inhibited colony forming capacity and decreased cells migration and invasion [ 12 ]. On the other hand, another study in SW620 and HTC116 cells demonstrated the role of this lncRNA in suppression of proliferation and migration.…”

Section: Cell Line Studiesmentioning

confidence: 99%

“… Cancer type Targets/Regulators and Signaling Pathways Assessed cell lines Function Reference Gastric cancer STAU1, KLF2, CDKN2B/P15 and CDKN1A/P21 MGC803, BGC823, MKN45 and SGC7901, and the normal gastric epithelium cell line GES1 Δ TINCR: ↓ cell proliferation, ↓ colony formation, ↓ tumorigenicity, ↑ apoptosis ↑ TINCR: ↑ cell growth, ↑ cell cycle progression [ 6 ] E2F1/TINCR/STAU1/CDKN2B signaling axis MGC803, BGC823, MKN45, AGS, SGC7901 and GES-1 Δ TINCR: ↓ cell proliferation [ 11 ] – HGC27, AGS, SGC-7901, MGC803 and GES-1 An approximately two-fold upregulated expression could be observed in GC cell lines for the lncRNAs TINCR. [ 10 ] miR-375/PDK1 KATO III, NCI-N87, HGC-27, and SNU-1 Δ TINCR: ↑ apoptosis, ↓ cell proliferation [ 4 ] Colorectal cancer miR‐7‐5p/PI3K/Akt/mTOR signaling pathway HCT116, HCT8, HT29, SW620 and SW480 ↑ TINCR: ↑ proliferation, ↑ migration, ↑ invasion [ 12 ] Wnt/β-catenin pathway LoVo, RKO, SW620, HCT116, SW480 and LS174T Δ TINCR: ↑ proliferation, ↑ migration, ↑ invasion [ 7 ] – SW620 and HTC116 cells ↑ TINCR: ↓ proliferation, ↓ migration [ 13 ] Esophageal squamous cell carcinoma (ESCC) – TE-13, KYSE-410, ECA-109, TE-1 and HEEC Δ TINCR: ↓ proliferation, ↓ migration, ↓ invasion, ↓ progression of cell cycle, ↑ apoptosis [ 22 ] …”

Section: Cell Line Studiesmentioning

confidence: 99%

“…Thus, they suggested that TINCR silencing intensely stimulates tumor growth and metastasis [ 7 ]. On the other hand, Yu et al have shown that stable knockdown of TINCR in HCT116 cells inhibits cancer cells growth and metastasis in BALB/c nude mice [ 12 ]. Two independent in vivo studies in breast cancer reached the similar results confirming the oncogenic role of TINCR in this kind of cancer [ 19 , 21 ].…”

Section: In Vivo Studiesmentioning

confidence: 99%

See 1 more Smart Citation

TINCR: An lncRNA with dual functions in the carcinogenesis process

Ghafouri‐Fard

Dashti

Taheri

et al. 2020

Non-coding RNA Research

View full text Add to dashboard Cite

Long non-coding RNAs (lncRNAs) have prominent roles in the pathogenesis of human cancers. Several studies have shown oncogenic or tumor suppressor roles of lncRNAs in different human tissues. Thus, these transcripts have been regarded as putative targets in treatment of cancer. The lncRNA terminal differentiation-induced non-coding RNA (TINCR) has an especial position in this regard, as it exerts different opposite roles in the pathogenesis of different human cancers. While it is up-regulated in gastric, esophageal, bladder and breast cancer; it is down-regulated in glioma, retinoblastoma and prostate cancer. Notably, data regarding expression profile of this lncRNA in a number of human cancers such as colon cancer, squamous cell carcinoma, non-small cell lung cancer (NSCLC) and hepatocellular carcinoma (HCC) are controversial. Expression level of this lncRNA has been associated with clinical outcome in patients with gastric cancer, colorectal cancer, NSCLC and head and neck squamous cell carcinoma. Moreover, Kaplan-Meier analyses have shown correlation between expression levels of TINCR and patients survival in patients with lung cancer and HCC. A number of cellular pathways such as Wnt/β-catenin, ERK1/2‐SP3 and MAPK signaling pathways have been identified as targets of this lncRNA in different cancers. Moreover, the rs8113645, rs2288947 and rs8105637 within this lncRNA have been associated with risk of gastric and colorectal cancer. In conclusion, although the role of TINCR in the carcinogenesis is essential, based on the conflicting data regarding the direction of effect of this lncRNA, therapeutic targeting of this lncRNA is a complicated issue which should be considered in a tissue-specific or even individualized manner.

show abstract

Resveratrol improves estrus disorder induced by bisphenol A through attenuating oxidative stress, autophagy, and apoptosis

Jiao

Gao

Yong

et al. 2022

J Biochem & Molecular Tox

View full text Add to dashboard Cite

Bisphenol A (BPA), as a widely used plasticizer, is easily absorbed by animals and humans. It has certain toxic effects on various tissues, including liver, heart, kidney, testis, and ovary. The toxic effects of BPA on animal reproduction have aroused widespread concern, but its regulatory mechanism and antidote in female animals estrus cycle remain unclear. In this study, the results displayed that BPA destroyed the normal estrus cycle of mice through decreasing the levels of progesterone and estradiol. Furthermore, BPA significantly increased the levels of oxidative stress, autophagy, and apoptosis in ovaries and granulosa cells. Interestingly, we found that the natural antioxidant resveratrol rescued estrus disorder and impaired estradiol secretion, reduced the abnormal reactive oxygen species accumulation, autophagy, and apoptosis in BPA exposed ovarian tissues. Moreover, transmission electron microscopy showed that resveratrol reduced BPA‐induced autophagic vesicles formation and flow cytometry showed that resveratrol inhibited the increase of apoptotic cells induced by BPA on granulosa cells. Therefore, the supplement of resveratrol could restore BPA‐induced estrus disorder by protecting ovarian granulosa cells. Overall, resveratrol is a potential drug to alleviate BPA‐induced estrous cycle disorders and ovarian damage.

show abstract

Adverse effects of bisphenol A on Sertoli cell blood-testis barrier in rare minnow Gobiocypris rarus

Cited by 43 publications

References 50 publications

The Relationship Between Widespread Pollution Exposure and Oxidized Products of Nucleic Acids in Seminal Plasma and Urine in Males Attending a Fertility Center

The Relationship Between Widespread Pollution Exposure and Oxidized Products of Nucleic Acids in Seminal Plasma and Urine in Males Attending a Fertility Center

TINCR: An lncRNA with dual functions in the carcinogenesis process

Resveratrol improves estrus disorder induced by bisphenol A through attenuating oxidative stress, autophagy, and apoptosis

Contact Info

Product

Resources

About