Adverse effects of chemoradiotherapy on invasion and metastasis of tumor cells

Xiong, Wei; Liao, Yong; Qin, Jiyong; Li, Wenhui; Tang, Zhao–You

doi:10.1016/j.gendis.2020.04.004

Cited by 12 publications

(7 citation statements)

References 81 publications

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“…These results are also in line with literature data, where increased vessel permeabilisation due to 3PO or other means such as radiotherapy or hyperthermia can result in increased metastases. (46) Tumor vessel normalization by means of chemical of pharmacological means has been typically associated with a reduction in tumor malignancy. (47)…”

Section: Evaluation Of 3po Treatment On Metastasesmentioning

confidence: 99%

Vessel normalization and maturation promotes nanoparticle delivery to solid tumors while minimizing metastases

Izci

Maksoudian

Gonçalves

et al. 2023

Preprint

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Nanoparticle delivery to solid tumors is known to be an inefficient process and various studies have tried to increase efficacy, but mechanistic and comparative studies remain scarce. Here, we use pharmacological agents to study the effect of vessel normalization or vessel disintegration on nanoparticle delivery to solid tumors. Using a multiparametric approach, we find that vessel disintegration fails to improve nanoparticle delivery and instead seems to have a limiting effect. Vessel normalization, however, improves delivery efficacy for nanoparticles ranging from 20 to 60 nm diameter. The normalization of the tumor blood vessels results in reduced hypoxia, reduced necrosis and an increase in Plvap+ CD276+ endothelial cells, which have been linked with nanoparticle delivery. Interestingly, where vessel disintegration stimulated cancer cell intravasation and associated metastases, vessel normalization impeded these processes. Together, these data reveal that, vessel normalization may be a safer and more suited approach for improving nanoparticle delivery to solid tumors, but its efficacy is limited by nanoparticle diameter and tumor parameters.

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Section: Evaluation Of 3po Treatment On Metastasesmentioning

confidence: 99%

Vessel normalization and maturation promotes nanoparticle delivery to solid tumors while minimizing metastases

Izci

Maksoudian

Gonçalves

et al. 2023

Preprint

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“…It plays an important role in tumor development, maintenance, and progression (15). Studies have shown that autophagy is a double-edged sword, as it promotes CRC invasion and metastasis and CRC cell apoptosis (16,17). Current studies show that tumor autophagy can predict patient prognosis (18,19).…”

Section: Introductionmentioning

confidence: 99%

A Novel Prognostic Prediction Model for Colorectal Cancer Based on Nine Autophagy-Related Long Noncoding RNAs

Yang

Wang

et al. 2021

Front. Oncol.

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IntroductionColorectal cancer (CRC) is the most common gastrointestinal cancer and has a low overall survival rate. Tumor–node–metastasis staging alone is insufficient to predict patient prognosis. Autophagy and long noncoding RNAs play important roles in regulating the biological behavior of CRC. Therefore, establishing an autophagy-related lncRNA (ARlncRNA)-based bioinformatics model is important for predicting survival and facilitating clinical treatment.MethodsCRC data were retrieved from The Cancer Genome Atlas. The database was randomly divided into train set and validation set; then, univariate and multivariate Cox regression analyses were performed to screen prognosis-related ARlncRNAs for prediction model construction. Interactive network and Sankey diagrams of ARlncRNAs and messenger RNAs were plotted. We analyzed the survival rate of high- and low-risk patients and plotted survival curves and determined whether the risk score was an independent predictor of CRC. Receiver operating characteristic curves were used to evaluate model sensitivity and specificity. Then, the expression level of lncRNA was detected by quantitative real-time polymerase chain reaction, and the location of lncRNA was observed by fluorescence in situ hybridization. Additionally, the protein expression was detected by Western blot.ResultsA prognostic prediction model of CRC was built based on nine ARlncRNAs (NKILA, LINC00174, AC008760.1, LINC02041, PCAT6, AC156455.1, LINC01503, LINC00957, and CD27-AS1). The 5-year overall survival rate was significantly lower in the high-risk group than in the low-risk group among train set, validation set, and all patients (all p < 0.001). The model had high sensitivity and accuracy in predicting the 1-year overall survival rate (area under the curve = 0.717). The prediction model risk score was an independent predictor of CRC. LINC00174 and NKILA were expressed in the nucleus and cytoplasm of normal colonic epithelial cell line NCM460 and colorectal cancer cell lines HT29. Additionally, LINC00174 and NKILA were overexpressed in HT29 compared with NCM460. After autophagy activation, LINCC00174 expression was significantly downregulated both in NCM460 and HT29, while NKILA expression was significantly increased.ConclusionThe new ARlncRNA-based model predicts CRC patient prognosis and provides new research ideas regarding potential mechanisms regulating the biological behavior of CRC. ARlncRNAs may play important roles in personalized cancer treatment.

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“…Evidence suggests that targeting autophagy with natural products could be a potential therapeutic approach for cancer [61,62]. However, autophagy induced by chemotherapy or radiotherapy may impede apoptosis, leading to unfavorable conditions post anti-tumor therapy [63]. Detailed mechanisms of different anticancer drug treatments involving the interplay of autophagy and apoptosis remain poorly understood [64].…”

Section: Discussionmentioning

confidence: 99%

Exploring the Antiproliferative and Modulatory Effects of 1-Methoxyisobrassinin on Ovarian Cancer Cells: Insights into Cell Cycle Regulation, Apoptosis, Autophagy, and Its Interactions with NAC

Zigová,

Miškufová,

Budovská

et al. 2024

Molecules

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Ovarian cancer, a highly lethal malignancy among reproductive organ cancers, poses a significant challenge with its high mortality rate, particularly in advanced-stage cases resistant to platinum-based chemotherapy. This study explores the potential therapeutic efficacy of 1-methoxyisobrassinin (MB-591), a derivative of indole phytoalexins found in Cruciferae family plants, on both cisplatin-sensitive (A2780) and cisplatin-resistant ovarian cancer cells (A2780 cis). The findings reveal that MB-591 exhibits an antiproliferative effect on both cell lines, with significantly increased potency against cisplatin-sensitive cells. The substance induces alterations in the distribution of the cell cycle, particularly in the S and G2/M phases, accompanied by changes in key regulatory proteins. Moreover, MB-591 triggers apoptosis in both cell lines, involving caspase-9 cleavage, PARP cleavage induction, and DNA damage, accompanied by the generation of reactive oxygen species (ROS) and mitochondrial dysfunction. Notably, the substance selectively induces autophagy in cisplatin-resistant cells, suggesting potential targeted therapeutic applications. The study further explores the interplay between MB-591 and antioxidant N-acetylcysteine (NAC), in modulating cellular processes. NAC demonstrates a protective effect against MB-591-induced cytotoxicity, affecting cell cycle distribution and apoptosis-related proteins. Additionally, NAC exhibits inhibitory effects on autophagy initiation in cisplatin-resistant cells, suggesting its potential role in overcoming resistance mechanisms.

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Adverse effects of chemoradiotherapy on invasion and metastasis of tumor cells

Cited by 12 publications

References 81 publications

Vessel normalization and maturation promotes nanoparticle delivery to solid tumors while minimizing metastases

Vessel normalization and maturation promotes nanoparticle delivery to solid tumors while minimizing metastases

A Novel Prognostic Prediction Model for Colorectal Cancer Based on Nine Autophagy-Related Long Noncoding RNAs

Exploring the Antiproliferative and Modulatory Effects of 1-Methoxyisobrassinin on Ovarian Cancer Cells: Insights into Cell Cycle Regulation, Apoptosis, Autophagy, and Its Interactions with NAC

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