Adverse effects of E150d on zebrafish development

Capriello, Teresa; Visone, Ilaria Mariarosaria; Motta, Chiara Maria; Ferrandino, Ida

doi:10.1016/j.fct.2020.111877

Cited by 12 publications

(3 citation statements)

References 50 publications

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“…Zebrafish embryos exposed to TTZ at a 10 mM concentration showed no obvious developmental toxicity, whereas each azo dye at an exposure level of 100 mM was completely fatal to embryos (Jiang et al., 2020; Joshi & Katti, 2018; Joshi & Pancharatna, 2019). In addition to the four colorants, caramel dye E150d dose‐dependently induced toxic effects on the hatching, survival, phenotype, and heartbeat of zebrafish embryos (6 hpf); impaired swimming ability; and caused skeletal muscle and pericardial cavity damage (Capriello et al., 2021). In addition, a study found that the food additive genipin showed developmental toxicity to zebrafish embryos, caused pericardial edema, and could cause cardiotoxicity, hepatotoxicity, and nephrotoxicity in zebrafish larvae (Xia et al., 2021).…”

Section: Research Progress In the Toxicological Assessment Of Hazards...mentioning

confidence: 99%

Zebrafish as model organisms for toxicological evaluations in the field of food science

Hou

Liu

Qin

et al. 2023

Comp Rev Food Sci Food Safe

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Food safety has long been an area of concern. The selection of stable and efficient model organisms is particularly important for food toxicology studies. Zebrafish (Danio rerio) are small model vertebrates, and 70% of human genes have at least one zebrafish ortholog. Zebrafish have advantages as model organisms due to their short life cycle, strong reproductive ability, easy rearing, and low cost. Zebrafish embryos have the advantage of being sensitive to the breeding environment and thus have been used as biosensors. Zebrafish and their embryos have been widely used for food toxicology assessments. This review provides a systematic and comprehensive summary of food toxicology studies using zebrafish as model organisms. First, we briefly introduce the multidimensional mechanisms and structure–activity relationship studies of food toxicological assessment. Second, we categorize these studies according to eight types of hazards in foods, including mycotoxins, pesticides, antibiotics, heavy metals, endocrine disruptors, food additives, nanoparticles, and other food‐related ingredients. Finally, we list the applications of zebrafish in food toxicology studies in line with future research prospects, aiming to provide a valuable reference for researchers in the field of food science.

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Section: Research Progress In the Toxicological Assessment Of Hazards...mentioning

confidence: 99%

Zebrafish as model organisms for toxicological evaluations in the field of food science

Hou

Liu

Qin

et al. 2023

Comp Rev Food Sci Food Safe

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show abstract

“…The compounds under investigation, Imidazoles, represent essential heterocyclic compounds with diverse applications in various therapeutic contexts. Imidazole, characterized by its planar ring with five members, exhibits solubility in water and other polar solvents [1,2]. Imidazole compounds encompass a wide spectrum of pharmacological actions.…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of 2-Methylimidazole and 4-Methylimidazole Exposure Effects on Zebrafish Larvae Mortality Rate

Riyaz,

Praveen Kumar

2024

E3S Web Conf.

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The study aimed to compare zebrafish embryo mortality rates under different 2-Methylimidazole (2-MI) and 4-Methylimidazole (4-MI) concentrations. Two exposure groups were created at a 40μM concentration using egg water. Thirty individuals were divided into two groups: Group 1 received an environmentally relevant dose of 2-MI, while Group 2 was exposed to 4-MI. Each group’s embryos (n=15 per plate) were observed from 4 to 96 hours post fertilization (hpf), adhering to OECD guidelines. Statistical analysis using SPSS maintained a 95% confidence level, 0.01 ratio, 80% power, and 1:1 enrollment ratio. Results showed a marked increase in mortality rate (71.87±1.25) in ecologically exposed embryos compared to 2-MI (45.73±0.79), with a significant P-value of 0.000 (P<0.05). Additionally, zebrafish exposed to 4-MI displayed a 20% lower mortality rate than 2-MI, supported by a significance threshold of p = 0.000 (p<0.05). These findings highlight the detrimental impact of early exposure to 2-MI and 4-MI on zebrafish embryo mortality rates, signifying developmental and embryotoxic implications.

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“…The nauplii of Artemia salina are a useful and accurate invertebrate model for applied toxicology, especially for their resistance to manipulation and fast development [14,15]. Danio rerio, commonly known as the zebrafish, is a widely used model organism for screening the eco-toxicological effects induced by environmental pollutants [16][17][18][19] including artificial dyes [7,9,20]. Finally, Cucumis sativus L. is a plant model organism, widely used to evaluate the toxic effects of different types of pollutants, i.e., dyes, heavy metals, and polycyclic aromatic hydrocarbons [7,21,22].…”

Section: Introductionmentioning

confidence: 99%

Commercial Red Food Dyes Preparations Modulate the Oxidative State in Three Model Organisms (Cucumis sativus, Artemia salina, and Danio rerio)

et al. 2022

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The growing environmental spreading of food synthetic dyes and bio-colors have the potential for altering organisms’ redox states. Here, three model species for aquatic pollution trials, Cucumis sativus seeds, Artemia salina cysts, and Danio rerio embryos, were short-term exposed to a fixed concentration of the artificial red E124, and two red bio-colors, cochineal E120, and vegan red (VEGR). In the animal models, we evaluated the total reactive oxygen species (ROS) and the susceptibility to in vitro oxidative stress, and in C. sativus, H2O2 production and antioxidant capacity. We also measured organismal performance indices (routine oxygen consumption in the animal models, dark oxygen consumption, and photosynthetic efficiency in C. sativus). In C. sativus, only E124 increased ROS and affected dark oxygen consumption and photosynthetic efficiency, while all dyes enhanced the antioxidant defenses. In the A. salina nauplii, all dyes increased ROS, while E120 and E124 reduced the susceptibility to oxidative stress. In D. rerio, treatments did not affect ROS content, and reduced oxidative stress susceptibility. Our data show that red food dyes affect the redox state of the developing organisms, in which ROS plays a significant role. We suggest a potentially toxic role for red food dyes with environmentally relevant consequences.

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Adverse effects of E150d on zebrafish development

Cited by 12 publications

References 50 publications

Zebrafish as model organisms for toxicological evaluations in the field of food science

Zebrafish as model organisms for toxicological evaluations in the field of food science

Comparative Analysis of 2-Methylimidazole and 4-Methylimidazole Exposure Effects on Zebrafish Larvae Mortality Rate

Commercial Red Food Dyes Preparations Modulate the Oxidative State in Three Model Organisms (Cucumis sativus, Artemia salina, and Danio rerio)

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