Adverse effects of herbal remedies

Smet, P A de

doi:10.1097/00012995-199704000-00001

Cited by 14 publications

(7 citation statements)

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“…8 Due to wholehearted demand in ethnomedicine in modern society, logical proof for the usefulness of numerous herbal remedies for various conditions is required and has been reported for a few of the phytomedicines. 9,10 This study, hence we explored the phytochemical compositions, acute toxicity as well as in-vitro free radical scavenging potential of O. kilimandscharicum plant.…”

Section: Issn: 2250-1177mentioning

confidence: 99%

Evaluation of preliminary phytochemical screening, acute toxicity and antioxidant profile of Ocimum kilimandscharicum

Saxena

Mittal

Siddiqui³

2019

J. Drug Delivery Ther.

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Nature has offered us diverse curative herbs having with powerful antioxidant phytochemicals. Ocimum (Lamiaceae) is a notable source of volatile oils and flavouring agents in general and primarily of eugenol, methyl eugenol, linalool, methyl chavicol, etc. Karpoora Thulasi is a member of this genus; nevertheless, not much literature has been reported on its safety and antioxidant potential. In this investigation, we did a pre-clinical safety assessment of concentrate of O. kilimandscharicum on Sprague Dawley rodents. Toxicological concordat of the O. kilimandscharicum concentrate was carried out following OECD guidelines 423. Further, to verify the traditional efficacy and elucidate the mechanism, the present study compared in-vitro antioxidant activity of the plant by DPPH, ABTS and Hydroxyl radical scavenging method using ascorbic acid as the standard. In acute oral toxicity, no treatment-related death or toxic signs were observed. Moreover, the study revealed that the O. kilimandscharicum extract could be well tolerated up to the dose 2000 mg/kg body weight and could be classified as Category 5. Moreover, ABTS free radical activity of the extract was 79.2148 while that of DDPH Inhibition potential was found to be 70.72758. Our findings present substantiation that the crude extracts of O. kilimandscharicum is a likely source of natural antioxidants, and this justified its long-established uses. Keywords: Ocimum kilimandscharicum, Acute Toxicity, In-vitro Antioxidant Activity DPPH, ABTS

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Section: Issn: 2250-1177mentioning

confidence: 99%

Evaluation of preliminary phytochemical screening, acute toxicity and antioxidant profile of Ocimum kilimandscharicum

Saxena

Mittal

Siddiqui³

2019

J. Drug Delivery Ther.

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“…Unlike conventional medications that generally consist of a standardized formulation of a specific agent in a known concentration, herbal preparations often consist of mixtures of ingredients, often in impure form and varying concentration. In one trial 19 corticosteroids, non-steroidal anti-inflammatory drugs and benzodiazepines were found in 'ethnic' remedies of Asian origin. The form a patient receives is dependent on geography, season and culture, as well as the expertise and preference of the practitioner.…”

Section: Herbal Formulationmentioning

confidence: 99%

“…2,17 Herbal medications are available in a variety of forms, including roots, seeds, leaves, teas, powders, oils, capsules and tablets. [19][20][21] In addition, botanical misidentification, product substitution or adulteration, and lack of compound stability have also been reported. For example, in rural areas of some developing countries patients are more likely to receive leaves, seeds and teas 'in season', whereas in the west, capsules and tablets are the preferred form and are available throughout the year.…”

Section: Herbal Formulationmentioning

confidence: 99%

Hepatotoxicity of Herbal Preparations

Strader¹,

Seeff²

2006

Zakim and Boyer's Hepatology

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“…Unfortunately, even 'natural' drugs may have significant toxicity (18)(19)(20). In fact, a good proportion of commonly used pharmaceuticals is derived from natural substances.…”

Section: Are Natural Drugs Safer Than Pharmaceutical Drugs?mentioning

confidence: 99%

Toxicological risks of herbal remedies

1999

Paediatrics &Amp; Child Health

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A lternative medicines (AMs) are used increasingly by cancer patients, people with chronic diseases and the general population, including children and youth. The public is exposed to AMs through the Internet, media, publications and friends. Herbal medicine, traditional Chinese medicine, homeopathy, naturopathic medicine, acupuncture, chiropractic and Ayurvedic medicine are well known examples of AMs. Energy medicine, magnetic field therapy, aromatherapy and oxygen therapy are some of the less recognized forms. During medical training, physicians receive minimal exposure to AMs. Physicians need to be aware of the potential risks that AMs pose to their patients. The present committee note presents a brief review of the potential toxicity of herbal remedies. It does not consider their therapeutic effects, many of which have not been confirmed by randomized clinical trials.

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Adverse effects of herbal remedies

Cited by 14 publications

References 0 publications

Evaluation of preliminary phytochemical screening, acute toxicity and antioxidant profile of Ocimum kilimandscharicum

Evaluation of preliminary phytochemical screening, acute toxicity and antioxidant profile of Ocimum kilimandscharicum

Hepatotoxicity of Herbal Preparations

Toxicological risks of herbal remedies

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