Adverse effects of honey on low-density lipoprotein cholesterol and adiponectin concentrations in patients with type 2 diabetes: a randomized controlled cross-over trial

Abstract

Background: Due to antioxidant and fructose content, honey may be a suitable sweetener for patients with type 2 diabetes. The aim was to investigate the long-term effect of natural honey on oxidative and inflammatory status of patients with type 2 diabetes. Methods: In a randomized controlled cross-over trial, 43 patients with type 2 diabetes were allocated to either natural honey (50 g/day) plus dietary recommendations or only dietary recommendations for 8 weeks with one month washout period in between. Dietary recommendations included weight maintenance diets for participants on honey treatment and a deficit of-150 kcal for those on control. Serum lipids, malondialdehyde, total antioxidant capacity, high-sensitivity C-reactive protein (hs-CRP), and adiponectin levels were measured at baseline and the end of each sequence. Results: Malondialdehyde (10.9%, p=0.01), hs-CRP (10.6%, p=0.003), and adiponectin (7.1%, p<0.001) concentrations significantly decreased in honey condition. Also, low-density lipoprotein (LDL) cholesterol (16.8%, p<0.001) significantly decreased in control and high-density lipoprotein (HDL) cholesterol significantly increased in both conditions. Between-group differences were only statistically significant for adiponectin (p=0.005) and LDL cholesterol (p=0.005). Energy intake increased during honey condition (9.4%, p=0.045) but the difference was not statistically significant between the two conditions (p=0.1). Conclusion: The results suggest that consumption of 50 g/day honey has adverse effects on LDL cholesterol and adiponectin levels in patients with type 2 diabetes. These adverse effects may occur because of high fructose content of honey.

Protective Effects of Honey-Processed Astragalus on Liver Injury and Gut Microbiota in Mice Induced by Chronic Alcohol Intake

“…e current results showed that both high-dose and low-dose HPA could significantly improve the abnormalities of serum lipids and liver lipids (TC, TG, and FFA) caused by alcohol (versus MG, Figures 1(a)-1(h)). HPA could obviously reduce the content of LDL-C and increased the content of HDL-C; this result was consistent with the study of Sadeghi et al [28]. Highdose HPA had the best effect in improving blood lipids.…”

Bee products consumption and cardiovascular diseases risk factors: a systematic review of interventional studies

“…[17] The last study was done by Sadeghi et al among 43 patients with T2DM using cross-over design . [28] Consumption of 50 g/day of honey for 8 weeks did not change any of the lipid profile parameters including TC, TG, LDL, and HDL (P > .05).…”

“…Eligible studies were conducted between 2007 and 2020, and the mean age of the participants was between 22 and 63. Of 23 included articles, 6 recruited healthy subjects , [13][14][15][16][17][18] while 11 were conducted among diabetic or pre-diabetic patients , [8,[19][20][21][22][23][24][25][26][27][28] and others included patients with chronic kidney disease (CKD) , [29] dry eye disease , [30] hypercholesterolemic patients , [31] nonalcoholic fatty liver disease (NAFLD) , [32] and overweight subjects . [33,34] Studies were mostly conducted in Iran (n = 14) [8,16,17,19,20,22-28,,3233] or Japan (n = 4) , [13,14,21,30] and the others were carried out in Brazil , [29] Chile , [15] Turkey , [18] Slovenia , [34] and Taiwan .…”

“…The effects of natural honey consumption on glycemic markers, anthropometric measures, lipid profile, or blood pressure were examined in 6 clinical trial studies . [16,17,20,26,28,33] In 2009, Bahrami et al conducted a randomized controlled clinical trial to evaluate the effects of natural honey consumption in diabetic patients. In this study, forty-eight diabetic patients were randomly assigned to the honey group and received natural honey orally (first 2 weeks, 1 g/kg/ day; second 2 weeks, 1.5 g/kg/day; third 2 weeks, 2 g/kg/day; and last 2 weeks, 2.5 g/kg/day) for 8 weeks, and the control group did not consume honey.…”

The effect of honey on lipid profiles: a systematic review and meta-analysis of controlled clinical trials

“…The latest meta-analysis on ten trials revealed the beneficial effects of honey on lipid profiles, including LDL-cholesterol, TAG and HDL-cholesterol (14) . However, some recent studies have not confirmed the lipid-lowering properties of honey (15,16) . Despite the numerous potential biological activities mentioned above, the real effects of honey consumption on cardiovascular systems and lipid profiles are still a matter of debate.…”