Adverse effects of microplastics and oxidative stress-induced MAPK/Nrf2 pathway-mediated defense mechanisms in the marine copepod Paracyclopina nana

Jeong, Chang Bum; Kang, Hye Min; Lee, Min Chul; Kim, Duck-Hyun; Han, Jeonghoon; Hwang, Dae Sik; Souissi, Sami; Lee, Su Jae; Shin, Kyung‐Hoon; Park, Heum Gi; Lee, Jae Seong

doi:10.1038/srep41323

Cited by 341 publications

(206 citation statements)

References 64 publications

Supporting

Mentioning

181

Contrasting

Unclassified

Order By: Relevance

“…), fecundity in P. nana (Jeong et al. ), growth in various benthic macroinvertebrates exposed to PS fragments (Redondo‐Hasselerharm et al. ), and algae ingestion in C. typicus (Cole et al.…”

Section: Discussionmentioning

confidence: 99%

“…For the smaller particles, this trend may be due to their increased bioavailability (Jeong et al. ) or due to their potential to translocate across the cell membrane (Browne et al. ).…”

Section: Discussionmentioning

confidence: 99%

“…4A). Some experimental studies that use multiple concentrations have detected dose-dependent relationships, such as for mortality in H. azteca (Au et al 2015), fecundity in P. nana (Jeong et al 2017), growth in various benthic macroinvertebrates exposed to PS fragments (Redondo-Hasselerharm et al 2018), and algae ingestion in C. typicus (Cole et al 2011). Although dose-response studies provide useful information on the toxicity of different types of microplastics, they often lack environmental relevancy due to their use of extremely high doses.…”

Section: A Deeper Dive Into Studies Testing the Effects Of Microplasticsmentioning

confidence: 99%

“…3F). For the smaller particles, this trend may be due to their increased bioavailability (Jeong et al 2017) or due to their potential to translocate across the cell membrane (Browne et al 2008). It may also be a result of the particles blocking the passage of food through the digestive tract or causing pseudo-satiation, which stops the organism from feeding (Anbumani and Kakkar 2018).…”

Section: A Deeper Dive Into Studies Testing the Effects Of Microplasticsmentioning

confidence: 99%

See 3 more Smart Citations

What is known and unknown about the effects of plastic pollution: A meta‐analysis and systematic review

Bucci

Túlio

Rochman

2020

Ecological Applications

453

263

View full text Add to dashboard Cite

As a consequence of the global ubiquity of plastic pollution, scientists, decision‐makers, and the public often ask whether macroplastics (>5 mm) and microplastics (<5 mm) have a realized ecological threat. In 2016, we conducted a systematic review of the literature and made a call for further research testing hypotheses about ecological effects. In the subsequent years, the amount of relevant research has risen tremendously. Here, we reassess the literature to determine the current weight of evidence about the effects of plastic pollution across all levels of biological organization. Our data spans marine, freshwater, and terrestrial environments. We extracted data from 139 lab and field studies testing 577 independent effects across a variety of taxa and with various types, sizes, and shapes of plastic. Overall, 59% of the tested effects were detected. Of these, 58% were due to microplastics and 42% were due to macroplastics. Of the effects that were not detected, 94% were from microplastics and 6% were from macroplastics. We found evidence that whether or not an effect is detected, as well as the severity and direction of the effect, is driven by dose, particle shape, polymer type, and particle size. Based on our analyses, there is no doubt that macroplastics are causing ecological effects, however, the effects of microplastics are much more complex. We also assessed the environmental relevancy of experimental studies by comparing the doses used in each exposure to the concentrations and sizes of microplastics found in the environment. We determined that only 17% of the concentrations used in experimental studies have been found in nature, and that 80% of particle sizes used in experiments fall below the size range of the majority of environmental sampling. Based on our systematic review and meta‐analysis, we make a call for future work that recognizes the complexity of microplastics and designs tests to better understand how different types, sizes, shapes, doses, and exposure durations affect wildlife. We also call for more ecologically and environmentally relevant studies, particularly in freshwater and terrestrial environments.

show abstract

Section: Discussionmentioning

confidence: 99%

“…For the smaller particles, this trend may be due to their increased bioavailability (Jeong et al. ) or due to their potential to translocate across the cell membrane (Browne et al. ).…”

Section: Discussionmentioning

confidence: 99%

Section: A Deeper Dive Into Studies Testing the Effects Of Microplasticsmentioning

confidence: 99%

Section: A Deeper Dive Into Studies Testing the Effects Of Microplasticsmentioning

confidence: 99%

See 2 more Smart Citations

What is known and unknown about the effects of plastic pollution: A meta‐analysis and systematic review

Bucci

Túlio

Rochman

2020

Ecological Applications

453

263

View full text Add to dashboard Cite

show abstract

“…As exposure to MP is correlated to oxidative stress [36], we measured the activity of catalase (CAT) and glutathione S-transferase (GST) in the worms after exposure to different HDPE MP percentages in soil. Exposure to the HDPE MP caused the CAT activity of the Enchytraeids to increase dose-dependently ( Figure 3A).…”

Section: Oxidative Stressmentioning

confidence: 99%

Enchytraeus crypticus Avoid Soil Spiked with Microplastic

Pflugmacher

Huttunen

Wolff

et al. 2020

Toxics

View full text Add to dashboard Cite

Microplastics (MPs) of varying sizes are widespread pollutants in our environment. The general opinion is that the smaller the size, the more dangerous the MPs are due to enhanced uptake possibilities. It would be of considerably ecological significance to understand the response of biota to microplastic contamination both physically and physiologically. Here, we report on an area choice experiment (avoidance test) using Enchytraeus crypticus, in which we mixed different amounts of high-density polyethylene microplastic particles into the soil. In all experimental scenarios, more Enchytraeids moved to the unspiked sections or chose a lower MP-concentration. Worms in contact with MP exhibited an enhanced oxidative stress status, measured as the induced activity of the antioxidative enzymes catalase and glutathione S-transferase. As plastic polymers per se are nontoxic, the exposure time employed was too short for chemicals to leach from the microplastic, and as the microplastic particles used in these experiments were too large (4 mm) to be consumed by the Enchytraeids, the likely cause for the avoidance and oxidative stress could be linked to altered soil properties.

show abstract

Microplastics Contamination in Receiving Water Systems

Junaid¹,

Wang²

2022

Microplastics in Urban Water Management

View full text Add to dashboard Cite

Adverse effects of microplastics and oxidative stress-induced MAPK/Nrf2 pathway-mediated defense mechanisms in the marine copepod Paracyclopina nana

Cited by 341 publications

References 64 publications

What is known and unknown about the effects of plastic pollution: A meta‐analysis and systematic review

What is known and unknown about the effects of plastic pollution: A meta‐analysis and systematic review

Enchytraeus crypticus Avoid Soil Spiked with Microplastic

Microplastics Contamination in Receiving Water Systems

Contact Info

Product

Resources

About