Adverse effects of obesity on breast cancer prognosis, and the biological actions of leptin (Review)

Rose, David P.; Gilhooly, Elaine M.; Nixon, Daniel W.

doi:10.3892/ijo.21.6.1285

Cited by 96 publications

(98 citation statements)

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“…A variety of evidence indicates that leptin is highly correlated with obesity-related carcinoma, such as breast cancer (Rose et al 2002) and hepatocellular carcinoma (Saxena et al 2007). High leptin levels are associated with advanced tumor stage and higher tumor grade in breast cancer (Goodwin et al 2005).…”

Section: Discussionmentioning

confidence: 99%

Leptin induces migration and invasion of glioma cells through MMP‐13 production

Yeh

Lee

et al. 2008

Glia

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Leptin, the product of the obses gene, plays an important role in the regulation of body weight by coordinating metabolism, feeding behavior, energy balance and neuroendocrine responses. However, central regulation of leptin gene expression is different from that in the adipocytes. In addition, leptin has been found in many tumor cell lines and has been shown to have mitogenic and angiogenic activity in a number of cell types. Glioma is the most common primary adult brain tumor with poor prognosis due to the spreading of tumor cell to the other regions of brain easily. Here we found that malignant C6 glioma cells expressed more leptin and leptin receptors than non-malignant astrocytes. Furthermore, it was found that exogenous application of leptin enhanced the migration and invasion of C6 glioma cells. In addition, we found that the expression of matrix metalloproteinase-13 (MMP-13) but not of MMP-2 and MMP-9 was increased in response to leptin stimulation. The leptin-induced increase of cell migration and invasion was antagonized by MMP-13 neutralizing antibody or silencing MMP-13. The up-regulation of MMP-13 induced by leptin was mainly through p38 MAP kinase and NF-κB pathway. In addition, migration-prone sublines demonstrate that cells with increasing migration ability had more expression of MMP-13 and leptin. Taken together, these results indicate that leptin enhanced migration and invasion of C6 glioma cells through the increase of 2

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Section: Discussionmentioning

confidence: 99%

Leptin induces migration and invasion of glioma cells through MMP‐13 production

Yeh

Lee

et al. 2008

Glia

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“…Recent reviews state that leptin is involved in increased susceptibility for cancer, particularly of the breast and prostate. [7][8][9][10] In this article we review the leptin pathway from the obesity state to PCa susceptibility and progression to advanced disease.…”

Section: Introductionmentioning

confidence: 99%

The link between obesity and prostate cancer: the leptin pathway and therapeutic perspectives

Ribeiro

Lopes

Medeiros

2005

Prostate Cancer Prostatic Dis

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Obesity-associated prostate cancer (PCa) remains controversial, although most studies rely on body mass index evaluation, which is an indirect measure of fatness. Studies using body fat measurement and disease stratification according to PCa stage found stronger associations between obesity and PCa. Leptin is a pleiotrophic hormone mainly synthesized by adipocytes that acts in peripheral organs such as the prostate. This article reviews obesity-associated leptin's pathophysiological role in PCa progression. PCa development results from some known risk factors. Currently, there is enough evidence suggesting that leptin is an additional factor involved in advanced PCa occurrence, and obesity association with high-grade disease. Life-long exposure to genetic and/or environmental susceptibility factors that predispose to obesity and higher leptin levels may increase the risk for advanced PCa.

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“…Numerous studies have established that obesity is a risk factor for breast cancer development in postmenopausal women (Cleary and Maihle, 1997;Chlebowski et al, 2002;Rose et al, 2002;Stephenson and Rose, 2003). Notably, a large body of evidence suggests that postmenopausal obesity, assessed by BMI, is associated with the increased risk of developing hormonedependent breast cancer (i.e., ER and progesterone receptor (PR)-positive tumors), but not with the incidence of ER/PR-negative tumors (Potter et al, 1995;Enger et al, 2000;.…”

Section: Breast Cancermentioning

confidence: 99%

Leptin and cancer

Garofalo

Surmacz

2005

Journal Cellular Physiology

556

497

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The prevalence of obesity has markedly increased over the past two decades, especially in the industrialized countries. While the impact of excess body weight on the development of cardiac disease and diabetes has been well documented, the link between obesity and carcinogenesis is just being recognized. This review will focus on the link between leptin, a cytokine that is elevated in obese individuals, and cancer development. First, we briefly discuss the biological functions of leptin and its signaling pathways. Then, we summarize the effects of leptin on different cancer types in experimental cellular and animal models. Next, we analyze epidemiological data on the relationship between obesity and the presence of cancer or cancer risk in patients. Finally, leptin as a target for cancer treatment and prevention will be discussed.

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Adverse effects of obesity on breast cancer prognosis, and the biological actions of leptin (Review)

Cited by 96 publications

References 0 publications

Leptin induces migration and invasion of glioma cells through MMP‐13 production

Leptin induces migration and invasion of glioma cells through MMP‐13 production

The link between obesity and prostate cancer: the leptin pathway and therapeutic perspectives

Leptin and cancer

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