Adverse effects of perfluoroalkyl acids on fish and other aquatic organisms: A review

Lee, Jin Wuk; Choi, Kyungho; Park, Sangshin; Seong, Chang-Ho; Yu, Seung Do; Kim, Pilje

doi:10.1016/j.scitotenv.2019.135334

Cited by 109 publications

(63 citation statements)

References 163 publications

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“…Lipid peroxidation is reported in fathead minnow (Pimephales promelas) embryos and zebrafish larvae in response to PFOS [307,313], in goldfish lymphocytes and freshwater tilapia hepatocytes exposed to PFOA [184,306], and in zebrafish embryos under PFOS, PFOA, and PFNA [308,314]. An interesting result was obtained in fathead minnow, where PFOA was discovered having a different effect in males rather than females, the former showing a significant increase in damaged lipids but no such change was observed in female fish [315].…”

Section: Chemical Datamentioning

confidence: 94%

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PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

Bonato

Corrà

Belli̇o

et al. 2020

IJERPH

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Due to their unique properties, perfluorinated substances (PFAS) are widely used in multiple industrial and commercial applications, but they are toxic for animals, humans included. This review presents some available data on the PFAS environmental distribution in the world, and in particular in Europe and in the Veneto region of Italy, where it has become a serious problem for human health. The consumption of contaminated food and drinking water is considered one of the major source of exposure for humans. Worldwide epidemiological studies report the negative effects that PFAS have on human health, due to environmental pollution, including infertility, steroid hormone perturbation, thyroid, liver and kidney disorders, and metabolic disfunctions. In vitro and in vivo researches correlated PFAS exposure to oxidative stress effects (in mammals as well as in other vertebrates of human interest), produced by a PFAS-induced increase of reactive oxygen species formation. The cellular antioxidant defense system is activated by PFAS, but it is only partially able to avoid the oxidative damage to biomolecules.

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Section: Chemical Datamentioning

confidence: 94%

“…Oncorhynchus mykiss PFOA CAT inhibition 4 [324] Oreochromis niloticus PFOA, PFOS Increased ROS formation 1 , lipid peroxidation 2 , GSH decrease 3 [306] Oryzias latipes PFOA SOD inhibition 4 , CAT inhibition 4 [322] Pelophylaxnigro maculatus PFOA nrf2 up-regulation 5 [313] Perca flavescens…”

Section: Pfoa Pfosmentioning

confidence: 99%

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

Bonato

Corrà

Belli̇o

et al. 2020

IJERPH

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show abstract

“…Lipid peroxidation is reported in fathead minnow (Pimephales promelas) embryos and zebrafish larvae in response to PFOS [304,310], in goldfish lymphocytes and freshwater tilapia hepatocytes exposed to PFOA [184,303], and in zebrafish embryos under PFOS, PFOA and PFNA [305,311]. An interesting result was obtained in fathead minnow, where PFOA was discovered having a different effect in males rather than females, the former showing a significant increase in damaged lipids but no such change was observed in female fish [312].…”

Section: Chemical Datamentioning

confidence: 95%

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

Bonato¹,

Corrà²,

Belli̇o³

et al. 2020

Preprint

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Due to their unique properties, perfluorinated substances (PFAS) are widely used in multiple industrial and commercial applications, but they are toxic for animals, humans included. This review presents some available data on the PFAS environmental distribution in the world, and in particular in Europe and in Veneto region of Italy, where it has become a serious problem for human health. The consumption of contaminated food and drinking water is considered one of the major source of exposure for humans. Worldwide epidemiological studies report the negative effects that PFAS have on human health, due to environmental pollution, including infertility, steroid hormone perturbation, thyroid, liver and kidney disorders and metabolic disfunctions. In vitro and in vivo researches correlated PFAS exposure to oxidative stress effects (in mammals as well as in other vertebrates of human interest), produced by a PFAS-induced increase of reactive oxygen species formation. The cellular antioxidant defense system is activated by PFAS, but it is only partially able to avoid the oxidative damage to biomolecules.

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“…Different PFAS have been shown to elicit oxidative stress and apoptosis in fish both in vitro and in vivo. The hallmark cellular changes associated with oxidative stress(such as increased reactive oxygen species, decreased glutathione levels, decreased superoxide dismutase and catalase levels, and increased lipid peroxidation) have been reported in several studies(Lee et al 2019). The actual mechanism(s) through which PFAS induce oxidative stress are not well understood, but increased β-oxidation of fatty acids and mitochondrial toxicity have been proposed as triggers.…”

mentioning

confidence: 99%

“…For example, based on existing and emerging knowledge concerning molecular/biochemical perturbations caused by different PFAS, pathways/apical outcomes associated with signaling controlled by estrogen, thyroid hormone, and PPARs would be worthy of consideration in terms of AOP development. These also were identified byLee et al (2019) as potentially important targets of PFAS in nonmammalian vertebrates.…”

mentioning

confidence: 99%

Assessing the Ecological Risks of Per‐ and Polyfluoroalkyl Substances: Current State‐of‐the Science and a Proposed Path Forward

Ankley

Cureton

Hoke

et al. 2020

Enviro Toxic and Chemistry

235

150

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Per-and poly-fluoroalkyl substances (PFAS) encompass a large, heterogenous group of chemicals of potential concern to human health and the environment. Based on information for a few relatively well understood PFAS such as perfluorooctane sulfonate and perfluorooctanoate, there is ample basis to suspect that at least a subset can be considered persistent, bioaccumulative, and/or toxic. However, data suitable for determining risks in either prospective or retrospective assessments are lacking for the majority of PFAS. In August 2019, the Society of Environmental Toxicology and Chemistry sponsored a workshop that focused on the state-of-the-science supporting risk assessment of PFAS. This paper summarizes discussions concerning ecotoxicology and ecological risks of PFAS. First, we summarize currently available information relevant to problem formulation/prioritization, exposure, and hazard/effects of PFAS in the context of regulatory and ecological risk assessment activities from around the world. We then describe critical gaps and uncertainties relative to ecological risk assessments for PFAS and propose approaches to address these needs. Recommendations include the development of more comprehensive monitoring programs to support exposure assessment, an emphasis on research to support the formulation of predictive models for bioaccumulation, and the development of in silico, in vitro, and in vivo methods to efficiently assess biological effects for potentially sensitive species/endpoints. Addressing needs associated with assessing the ecological risk of PFAS will require cross-disciplinary approaches that employ both conventional and new methods in an integrated, resource-effective manner.

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Adverse effects of perfluoroalkyl acids on fish and other aquatic organisms: A review

Cited by 109 publications

References 163 publications

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

Assessing the Ecological Risks of Per‐ and Polyfluoroalkyl Substances: Current State‐of‐the Science and a Proposed Path Forward

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