Adverse Effects of Systemic Glucocorticosteroid Therapy in Infants With Hemangiomas

George, Manju; Sharma, Vidya; Jacobson, Jill D.; Simon, Stephen D.; Nopper, Amy J.

doi:10.1001/archderm.140.8.963

Cited by 130 publications

(83 citation statements)

References 54 publications

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“…229 236 These include irritability, fussiness, insomnia, and personality changes. 230,234,236,237 Osteopenia is a known adverse effect of long-term systemic corticosteroid therapy but is rarely observed in children with IH, which presumably is related to the relatively short duration and nonrepetitive nature of therapy typically used for the treatment of IHs. Hypertension is also a risk of systemic corticosteroid therapy, but the percentage of affected individuals is unknown and is likely dose dependent.…”

Section: Adverse Effects Of Corticosteroid Therapymentioning

confidence: 99%

Diagnosis and Management of Infantile Hemangioma

Darrow¹,

Mancini²,

Nopper³

et al. 2015

Pediatrics

217

290

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Infantile hemangiomas (IHs) are the most common tumors of childhood. Unlike other tumors, they have the unique ability to involute after proliferation, often leading primary care providers to assume they will resolve without intervention or consequence. Unfortunately, a subset of IHs rapidly develop complications, resulting in pain, functional impairment, or permanent disfigurement. As a result, the primary clinician has the task of determining which lesions require early consultation with a specialist. Although several recent reviews have been published, this clinical report is the first based on input from individuals representing the many specialties involved in the treatment of IH. Its purpose is to update the pediatric community regarding recent discoveries in IH pathogenesis, treatment, and clinical associations and to provide a basis for clinical decision-making in the management of IH.

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Section: Adverse Effects Of Corticosteroid Therapymentioning

confidence: 99%

Diagnosis and Management of Infantile Hemangioma

Darrow¹,

Mancini²,

Nopper³

et al. 2015

Pediatrics

217

290

View full text Add to dashboard Cite

show abstract

“…The standard treatment options for IH include corticosteroids or surgical excision, and the options in life-or sight-threatening cases include treatment with vincristine, interferon or cyclophosphamide. Unfortunately, none of these therapeutic modalities are ideal due to restrictions or potential serious side effects [4][5][6][7]. β-blockers have recently been introduced as a safe and effective treatment for IH [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Wnt3a Expression is Associated with MMP-9 Expression in Primary Tumor and Metastatic Site in Recurrent or Stage IV Colorectal Cancer

2014

Cancer Cell Signaling

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Infantile hemangioma (IH), which is the most common tumor in infants, is a benign vascular neoplasm resulting from the abnormal proliferation of endothelial cells and pericytes. For nearly a century, researchers have noted that IH exhibits diverse and often dramatic clinical behaviors. On the one hand, most lesions pose no threat or potential for complication and resolve spontaneously without concern in most children with IH. On the other hand, approximately 10% of IHs are destructive, disfiguring and even vision-or life-threatening. Recent studies have provided some insight into the pathogenesis of these vascular tumors, leading to a better understanding of the biological features of IH and, in particular, indicating that during hemangioma neovascularization, two main pathogenic mechanisms prevail, angiogenesis and vasculogenesis. Both mechanisms have been linked to alterations in several important cellular signaling pathways. These pathways are of interest from a therapeutic perspective because targeting them may help to reverse, delay or prevent hemangioma neovascularization. In this review, we explore some of the major pathways implicated in IH, including the VEGF/VEGFR, Notch, β-adrenergic, Tie2/angiopoietins, PI3K/AKT/mTOR, HIF-α-mediated and PDGF/PDGF-R-β pathways. We focus on the role of these pathways in the pathogenesis of IH, how they are altered and the consequences of these abnormalities. In addition, we review the latest preclinical and clinical data on the rationally designed targeted agents that are now being directed against some of these pathways.

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“…6,8,32,35 Terapi kortikosteroid oral jangka panjang dapat menimbulkan efek samping yang buruk seperti gangguan pertumbuhan, efek Cushingoid dan infeksi. [36][37][38] Efek samping lain dari kortikosteroid yang pernah dilaporkan adalah penekanan sistem immun dengan mengurangi migrasi neurophil ketempat peradangan, sebaiknya hindari pemberian vaksinasi kuman hidup terhadap pasien yang mendapat terapi jangka panjang kortikosteroid. 26 Aviles melaporkan adanya infeksi Pneumocystis carinii pada anak usia 3 bulan dengan HI setelah diberikan methyl prednisolon 3 m/kgbb/hari intravena selama 6 minggu.…”

Section: Kurva Pertumbuhan Rich Nich Dan Hemangioma Infantil (Ih)unclassified

Terapi Vincristine dan Triamcinolone dalam pengobatan Hemangioma Infantil

Herdata

Gatot

Windiastuti

2016

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Adverse Effects of Systemic Glucocorticosteroid Therapy in Infants With Hemangiomas

Cited by 130 publications

References 54 publications

Diagnosis and Management of Infantile Hemangioma

Diagnosis and Management of Infantile Hemangioma

Wnt3a Expression is Associated with MMP-9 Expression in Primary Tumor and Metastatic Site in Recurrent or Stage IV Colorectal Cancer

Terapi Vincristine dan Triamcinolone dalam pengobatan Hemangioma Infantil

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