Adverse effects of topical photodynamic therapy: a consensus review and approach to management

Ibbotson, S.H.; Wong, Terence H.; Morton, C.A.; Collier, N.J.; Haylett, Ann K.; McKenna, Kevin E.; Mallipeddi, R.; Moseley, Harry; Rhodes, Lesley E.; Seukeran, D.C.; Ward, Katherine; Mustapa, M.F. Mohd; Exton, L.S.

doi:10.1111/bjd.17131

Cited by 60 publications

(39 citation statements)

References 203 publications

(281 reference statements)

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“…This review of PDT for the treatment of BCC evolved from an earlier work by the authors on the guidelines for topical PDT [1] and a systematic review and meta-analysis of conventional and topical PDT for BCC and related works [4,7,8]. The current evaluation gives the opportunity to set the previous works in context, to include a wider range of publications, to shed light on the current limitations of PDT for the treatment of BCC, and to indicate promising areas of further research to address these.…”

Section: Background Aims and Methodsmentioning

confidence: 99%

“…Although sBCC is the most susceptible BCC subtype to topical PDT treatment and, being intrinsically thin, is relatively free from penetration problems of either light or the prodrug, remaining problems exist, and these are illustrated in Figure 4. Pain/discomfort during irradiation is a prominent adverse effect of conventional topical PDT [4,8]. However, this does not usually prevent successful delivery of the treatment, although, in some cases, it may require the treatment to be paused and/or local anesthesia to be used [4,8].…”

Section: Outcomes Of Topical Pdt Treatment Of Bccmentioning

confidence: 99%

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Photodynamic Therapy for Basal Cell Carcinoma: The Clinical Context for Future Research Priorities

Collier

Rhodes

2020

Molecules

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Photodynamic therapy (PDT) is an established treatment option for low-risk basal cell carcinoma (BCC). BCC is the most common human cancer and also a convenient cancer in which to study PDT treatment. This review clarifies challenges to researchers evident from the clinical use of PDT in BCC treatment. It outlines the context of PDT and how PDT treatments for BCC have been developed hitherto. The sections examine the development of systemic and subsequently topical photosensitizers, light delivery regimens, and the use of PDT in different patient populations and subtypes of BCC. The outcomes of topical PDT are discussed in comparison with alternative treatments, and topical PDT applications in combination and adjuvant therapy are considered. The intention is to summarize the clinical relevance and expose areas of research need in the BCC context, ultimately to facilitate improvements in PDT treatment.

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Section: Background Aims and Methodsmentioning

confidence: 99%

Section: Outcomes Of Topical Pdt Treatment Of Bccmentioning

confidence: 99%

Photodynamic Therapy for Basal Cell Carcinoma: The Clinical Context for Future Research Priorities

Collier

Rhodes

2020

Molecules

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“…Although there is no convincing evidence of a carcinogenic risk of PDT, vigilance is recommended. Details and references of the adverse effects of topical PDT are included in a separate review …”

Section: Adverse Effectsmentioning

confidence: 99%

British Association of Dermatologists and British Photodermatology Group guidelines for topical photodynamic therapy 2018

et al. 2018

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“…In most cases, PDT is well tolerated, the main side effects being pain, erythema and, in some cases, urticaria. Scar formation or other allergic reactions may occur less frequently (42,43).…”

Section: Photodynamic Therapya Promising Therapymentioning

confidence: 99%

Photodynamic therapy as a new therapeutic approach of oral lichen planus

Tocut¹,

Mitran²,

Mitran³

et al. 2019

JMMS

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Oral lichen planus (OLP) is a chronic, immunologically mediated disease, defined by periods of exacerbation and quiescence. The disease is associated with a low mortality risk, but in some instances, morbidity can be important, especially in extensive, erosive forms, with a significant impact on the quality of life. OLP is a chronic T-cell mediated inflammatory disease involving the oral cavity, the most common lesions being located on the oral mucosa, tongue and gums. Its etiology remains in part unknown, but several factors proved to be involved in the development of the disease (drugs, dental materials, infectious agents, psychological factors, autoimmunity and genetic predisposition). The therapeutic approach should take into account the type of lesion and the extent of the disease, as well as the possible adverse effects. Although several therapies are available, OLP treatment still remains a challenge. Photodynamic therapy (PDT) is widely used in dermatology, finding applicability in the treatment of an increasing number of conditions. Recent research has shown the role of PDT in the treatment of OLP. It is a minimally invasive therapy with few side effects and promising results. Keywords  oral lichen planus, photosensitizer, therapy Highlights  The therapeutic approach in the OLP remains a challenge; although many therapies are available, none of them can still be considered the ideal therapeutic approach.  PDT seems to be a promising therapy, but with heterogeneous results due to lack of standardization (the available studies using different sources of light, wavelengths and photosensitizers).

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Adverse effects of topical photodynamic therapy: a consensus review and approach to management

Cited by 60 publications

References 203 publications

Photodynamic Therapy for Basal Cell Carcinoma: The Clinical Context for Future Research Priorities

Photodynamic Therapy for Basal Cell Carcinoma: The Clinical Context for Future Research Priorities

British Association of Dermatologists and British Photodermatology Group guidelines for topical photodynamic therapy 2018

Photodynamic therapy as a new therapeutic approach of oral lichen planus

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