Adverse effects on insulin secretion of replacing saturated fat with refined carbohydrate but not with monounsaturated fat: A randomized controlled trial in centrally obese subjects

Abstract

In conclusion, a 6-week lower-fat/higher-carbohydrate (increased by 7% refined carbohydrate) diet may have greater adverse effect on insulin secretion corrected for glucose compared with isocaloric higher-fat diets. In contrast, exchanging MUFA for SAFA at 7% energy had no appreciable adverse impact on insulin secretion.

Effects of diets rich in ghee or olive oil on cardiometabolic risk factors in healthy adults: a two-period, crossover, randomised trial

“…Regarding postprandial glycaemic response, the two test meals showed similar postprandial glucose and insulin responses. These findings are somewhat consistent with the results of other studies in which the effects of (35) . Roche et al evaluated the postprandial response during 9 h after the ingestion of meals containing different proportions of MUFA and SFA in healthy males and reported no significant difference in postprandial plasma glucose and insulin response (36) .…”

“…These findings are somewhat consistent with the results of other studies in which the effects of diets or meals rich in SFA or MUFA have been compared. Chang et al investigated the effect of MUFA or SFA-enriched diets in centrally obese subjects and found no significant difference between SFA or MUFA diets on fasting and postprandial insulin and glucose secretion 35 Accepted manuscript healthy males and reported no significant difference in postprandial plasma glucose and insulin response 36 . Itoh et al evaluated the glucose and insulin responses after the ingestion of an SFA enriched high-fat meal or a reduced SFAs high-fat meal in healthy women and found no difference in insulin response between SFA enriched and reduced SFAs high-fat meals 37 .…”

Avocado Fruit on Postprandial Markers of Cardio-Metabolic Risk: A Randomized Controlled Dose Response Trial in Overweight and Obese Men and Women

“…Epidemiologic studies have revealed that consumption of refined carbohydrate-containing diets and/or diets high in saturated fat (SFA) is associated with increased risk for coronary heart disease [ 1 ] and increased prevalence of type 2 diabetes [ 2 ]. Interventional trials have shown that consumption of relatively high amounts (52–62% carbohydrate energy) of refined carbohydrates induces adverse effects on glycemic [ 3 ] and blood lipid regulation [ 4 , 5 ] and regular intake of SFA and trans fats have been shown to increase total and low-density lipoprotein (LDL) cholesterol [ 6 , 7 ]. Accordingly, diets containing unwarranted amounts of refined carbohydrates and SFA are considered risk factors in developing metabolic and glycemic disturbances making them targets for control.…”

The relationship of saturated fats and coronary heart disease: fa(c)t or fiction? A commentary

“…The risk of coronary heart disease (CHD) associated with saturated fatty acids (SFA) varies from no association to a significantly important risk. 1–52 CHD is the number one cause of death in the USA, accounts for approximately 17% of deaths, and is associated with over 1 million myocardial infarctions (MIs) each year. 1,22 Nutrition and modification of diet make up one of the primary lifestyle approaches to preventing CHD with a major focus on the reduction of dietary SFA intake.…”