Adverse events after BNT162b2 mRNA COVID-19 vaccination in health care workers and medical students in Japan

Acute adverse events of Sars-CoV2 vaccines: Experiences from a health care worker vaccination campaign in two municipal hospitals in northwest Germany

“…Focusing on health care workers, vaccination appears highly effective and safe [15] . However, reports from around the globe mostly indicate rates of adverse events which are similar or even higher than in our cohort ranging from 77% in a collection from Mexico up to 98% in a cohort from the U.S. [16] , [17] , [18] , [19] with a substantial contribution of psychological and social effects triggered by the pandemic [20] . Interestingly, it could be reconfirmed that high rates of adverse events correlate with post-vaccination antibody levels [18] .…”

Sex-disaggregated outcomes of adverse events after COVID-19 vaccination: A Dutch cohort study and review of the literature

“…After exclusion of 340 irrelevant articles based on title or abstract, 96 articles were subjected to full-text screening of which 84 were eligible to be included in the review ( Supplementary Figure S3 and Table S8). Forty-three of these articles concerned cross-sectional studies (51.2%) ( 12 , 13 , 17 – 57 ), 26 were prospective cohort studies (31.0%) ( 2 , 5 , 14 , 58 – 80 ), eight retrospective cohort studies (9.5%) ( 81 – 88 ) and seven were other types of studies ( 6 , 89 – 94 ) (8.3%). The majority of the studies were performed in Europe (n=26, 31.0%), in Asia (n=24, 28.6%) and in the Middle East (n=21, 25.0%).…”

“…Nearly all articles reported a higher incidence of AEFIs in females compared to males with the exception of four articles which found an opposite outcome, for most of which no clear reason could be identified other than a possible skewed distribution of the sexes and age groups in the studies ( 17 , 18 , 80 , 85 ). Of the 21 articles which reported a OR of any adverse reaction for sex, the median OR was 1.93 (range: 0.85-3.45, IQR 1.49-2.50) using males as reference group ( Supplementary Table S8 ) ( 2 , 6 , 13 , 22 , 24 , 25 , 34 , 43 , 45 – 47 , 52 , 54 , 56 , 61 , 63 , 66 , 68 , 79 , 81 , 85 ). Similarly, females had a median 1.96 times higher odds of reporting a local reaction compared to males (range: 1.02-2.90, IQR1.85-2.54) ( 22 , 32 , 42 , 54 , 76 ).…”

“…Several studies report a significant higher incidence of reported AEFIs after COVID-19 vaccination in females than males (12)(13)(14). Yet, only a limited number of studies focus specifically on the association between the occurrence of AEFIs and sex.…”