Adverse Events Associated with Nonsurgical Treatments for Urinary Incontinence in Women: a Systematic Review

Balk, Ethan M; Adam, Gaelen P; Corsi, Katherine; Mogul, Amanda; Trikalinos, Thomas A; Jeppson, Peter C.

doi:10.1007/s11606-019-05028-0

Cited by 5 publications

(4 citation statements)

References 142 publications

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“…However, compliance is always a problem for patients with catheters or external collecting devices [13]. Oral medication of detrusor overactivity is associated with several complications such as cognitive damage and dry mouth [3,14]. The effectiveness of behaviour training, acupuncture, and pelvic floor muscle exercises remains unclear [1,7,[15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of repetitive transcranial magnetic stimulation against poststroke urinary incontinence: a study protocol for a randomized controlled trial

Jiang

Tang

Song

et al. 2022

Trials

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Background and purpose Poststroke urinary incontinence (PSI) is prevalent in stroke survivors, and high-quality evidence is required to guide clinical practice. Previous studies have demonstrated the curative effect of repetitive transcranial magnetic stimulation (rTMS) for urinary incontinence in individuals with multiple sclerosis (MS), Parkinson’s disease (PD), and spinal cord injury (SCI). Here, we describe the protocol for a randomized controlled trial to evaluate the efficacy and safety of low-frequency rTMS on the contralesional primary motor cortex (M1) for the treatment of PSI. Methods and analysis In this single-centre randomized controlled trial for poststroke urinary incontinence, a total of 140 eligible patients will be randomly allocated into two groups. The rTMS group (n = 70) will receive low-frequency rTMS at the M1 along with routine medical care, while the control group will receive sham rTMS along with routine medical care. All participants will undergo 20 treatment sessions, five times a week for 4 weeks. The primary outcome measures will be the changes in the urodynamic test at baseline versus 4 weeks after intervention. The secondary outcomes include the International Consultation on Incontinence Questionnaire Urinary Incontinence Short Form (ICIQ-UI SF), Overactive Bladder Symptom Score (OABSS), and pelvic floor muscle function. Ethics and dissemination The Institutional Review Board and Hospital Research Ethics Committee of the Second Affiliated Hospital of Chongqing Medical University approved this trial, and the approval number is No. 2020-153. All methods will be carried out in accordance with the principles of the Declaration of Helsinki and relevant ethical guidelines covering informed consent, confidentiality, and data storage. After the study had been thoroughly described to the participants by a physician, all participants will provide written informed consent indicating their willingness to participate. The results will be disseminated to most of the population, including participants, researchers, healthcare providers, and sponsors. Trial registration URL: https://www.chictr.org.cn; Unique identifier: ChiCTR2100042688. Date of Registration: 2021-01-26.

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Section: Introductionmentioning

confidence: 99%

Effectiveness of repetitive transcranial magnetic stimulation against poststroke urinary incontinence: a study protocol for a randomized controlled trial

Jiang

Tang

Song

et al. 2022

Trials

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“…Potential harm of PFMT is caused by incorrect training, which may lead to worsening of symptoms or the occurrence of pain. 7 PFMT may be cost-effective but further research is needed, as well as investigations into its long-term effectiveness. 8 Pessaries often relieve prolapse symptoms as well as PFMT and are cost effective.…”

Section: Introductionmentioning

confidence: 99%

Laser therapy for urinary incontinence and pelvic organ prolapse: a systematic review

Mackova

Daele

Page

et al. 2020

BJOG

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Background Laser therapy is now being proposed for the treatment of pelvic organ prolapse (POP) and urinary incontinence (UI). Objectives To systematically review the available literature on laser therapy for POP and UI. Search strategy PubMed, Web Of Science and Embase were searched for relevant articles, using a three‐concept (POP, UI, laser therapy) search engine composed as (concept 1 OR concept 2) AND concept 3. Selection criteria Only full‐text clinical studies in English. Data collection and analysis Data on patient characteristics, laser setting, treatment outcome and adverse events were independently collected by two researchers. There was a lack of methodological uniformity so meta‐analysis was not possible and the results are presented narratively. Main results Thirty‐one studies recruiting 1530 adult women met the inclusion criteria. All studies showed significant improvement either on UI, POP or both; however the heterogeneity of laser settings, application and outcome measures was huge. Only one study was a randomised controlled trial, two studies were controlled cohort studies. All three were on UI and used standardised validated tools. The risk of bias in the randomised controlled trial was low on all seven domains; the controlled studies had a serious risk of bias. No major adverse events were reported, mild pain and burning sensation were the most commonly described adverse events. Conclusions All studies on vaginal and/or urethral laser application for POP and UI report improvement, but the quality of studies needs to be improved. Tweetable abstract There is weak evidence that laser therapy is effective for urinary incontinence and pelvic organ prolapse #LASER#UI#POP.

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“…Recently published findings include interventions to reduce harmful medical errors in the hospital, 6 to improve pain management 7 and address opioid overprescribing, 8 and improve emergency care for patients with chest pain. 9 JGIM has published many papers supported by PCORI funding, including original investigations of clinical interventions, 10,11 systematic reviews of key clinical topics, 12,13 and overviews of methodological approaches. 14…”

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confidence: 99%

The Future of the Patient-Centered Outcomes Research Institute (PCORI)

Fischer

Asch

2019

J GEN INTERN MED

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Adverse Events Associated with Nonsurgical Treatments for Urinary Incontinence in Women: a Systematic Review

Cited by 5 publications

References 142 publications

Effectiveness of repetitive transcranial magnetic stimulation against poststroke urinary incontinence: a study protocol for a randomized controlled trial

Effectiveness of repetitive transcranial magnetic stimulation against poststroke urinary incontinence: a study protocol for a randomized controlled trial

Laser therapy for urinary incontinence and pelvic organ prolapse: a systematic review

The Future of the Patient-Centered Outcomes Research Institute (PCORI)

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