Adverse Events Associated With the Use of Cyclosporine in Patients With Inflammatory Bowel Disease

Sternthal, M.; Murphy, Seamus; George, James; Kornbluth, Asher; Lichtiger, Simon; Present, Daniel H.

doi:10.1111/j.1572-0241.2007.01718.x

Cited by 110 publications

(70 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Severe adverse events include nephrotoxicity, infection, and seizures (particularly in patients with associated hypocholesterolemia or hypomagnesemia). More common but less severe side eff ects include paresthesias, hypertension, hypertrichosis, headache, abnormal liver function tests, hyperkalemia, and gingival hyperplasia ( 282 ). During intervals of triple immunosuppression with steroids, CSA, and a thiopurine, many experts treat patients with prophylaxis against Pneumocystis jiroveci ( carinii ), such as trimethoprim / sulfamethoxazole or dapsone.…”

Section: The Patient With Severe Colitis Refractory To Maximal Oral Tmentioning

confidence: 99%

Ulcerative Colitis Practice Guidelines in Adults: American College of Gastroenterology, Practice Parameters Committee

Kornbluth

Sachar

2010

American Journal of Gastroenterology

Self Cite

1,156

977

View full text Add to dashboard Cite

Guidelines for clinical practice are aimed to indicate preferred approaches to medical problems as established by scientifi cally valid research. Double-blind placebo controlled studies are preferable, but compassionate-use reports and expert review articles are used in a thorough review of the literature conducted through Medline with the National Library of Medicine. When only data that will not withstand objective scrutiny are available, a recommendation is identifi ed as a consensus of experts. Guidelines are applicable to all physicians who address the subject regardless of specialty training or interests and are aimed to indicate the preferable but not necessarily the only acceptable approach to a specifi c problem. Guidelines are intended to be fl exible and must be distinguished from standards of care, which are infl exible and rarely violated. Given the wide range of specifi cs in any healthcare problem, the physician must always choose the course best suited to the individual patient and the variables in existence at the moment of decision. Guidelines are developed under the auspices of the American College of Gastroenterology and its Practice Parameters Committee and approved by the board of trustees. Each has been intensely reviewed and revised by the Committee, other experts in the fi eld, physicians who will use them, and specialists in the science of decision analysis. The recommendations of each guideline are therefore considered valid at the time of composition based on the data available. New developments in medical research and practice pertinent to each guideline will be reviewed at a time established and indicated at publication to assure continued validity. The recommendations made are based on the level of evidence found. Grade A recommendations imply that there is consistent level 1 evidence (randomized controlled trials), grade B indicates that the evidence would be level 2 or 3, which are cohort studies or case -control studies. Grade C recommendations are based on level 4 studies, meaning case series or poor-quality cohort studies, and grade D recommendations are based on level 5 evidence, meaning expert opinion.

show abstract

Section: The Patient With Severe Colitis Refractory To Maximal Oral Tmentioning

confidence: 99%

Ulcerative Colitis Practice Guidelines in Adults: American College of Gastroenterology, Practice Parameters Committee

Kornbluth

Sachar

2010

American Journal of Gastroenterology

Self Cite

1,156

977

View full text Add to dashboard Cite

show abstract

“…This may contribute to the finding that patients with UC who are unresponsive to corticosteroid therapy are good candidates for immunosuppressive treatment with cyclosporin A (CSA), a cyclic peptide that exerts an immunosuppressive effect by inhibiting IL-2 production (21). Although significant clinical improvement was achieved in CSA-treated patients compared with placebo, several adverse effects including paresthesias and hypertension were observed (21,26,46). These effects may be due to high IL-2 levels in UC patients.…”

Section: Discussionmentioning

confidence: 99%

Molecular mechanism of interleukin-2-induced mucosal homeostasis

Mishra

Waters

Kumar

2012

American Journal of Physiology-Cell Physiology

View full text Add to dashboard Cite

show abstract

“…In a study in pregnant women with organ transplant on cyclosporine, growth restriction and prematurity occurred in 40% of the neonates but no congenital defects were seen [Armenti et al 1994;Cockburn et al 1989]. Other side-effects include gingival hyperplasia, hirsutism, anorexia, nausea, vomiting, diarrhea and abdominal discomfort [Sternthal et al 2008]. …”

Section: Cyclosporinementioning

confidence: 99%

Review: Ulcerative colitis: current treatment strategies and future prospects

Garud

Peppercorn

2009

Therap Adv Gastroenterol

View full text Add to dashboard Cite

Ulcerative colitis (UC) is a disease of unknown etiology characterized by inflammation of the mucosa and occasionally the submucosa of the colon. Conventional drug therapy for UC involves use of aminosalicylates, corticosteroids, azathioprine/6-mercaptopurine, cyclosporine and anti-tumor necrosis factor therapy. Alternative therapies include probiotics, nicotine and fish oil. Drugs like tacrolimus, rosiglitazone and Trichuris suis ova are being evaluated for use in UC patients. With the new biologic agents, new treatment options for UC continue to evolve. In this article we will discuss the conventional drugs, the alternative therapies and the management strategies according to the severity and extent of UC.

show abstract

Adverse Events Associated With the Use of Cyclosporine in Patients With Inflammatory Bowel Disease

Cited by 110 publications

References 23 publications

Ulcerative Colitis Practice Guidelines in Adults: American College of Gastroenterology, Practice Parameters Committee

Ulcerative Colitis Practice Guidelines in Adults: American College of Gastroenterology, Practice Parameters Committee

Molecular mechanism of interleukin-2-induced mucosal homeostasis

Review: Ulcerative colitis: current treatment strategies and future prospects

Contact Info

Product

Resources

About